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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Metergoline Metergoline Metergoline PIS2M2 Metergoline PIS2M2 Metergoline PIS4M1 Metergoline PIS4M1 Metergoline PIS1M1 Metergoline PIS2M1 Metergoline PIS1M2 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Metergoline undergoes metabolism to give Metergoline PIS1M1, Metergoline PIS1M2, Metergoline PIS1M3, Metergoline PIS1M4 and Metergoline PIS2M1. Endoplasmic Reticulum Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Metergoline Metergoline Metergoline PIS2M2 Metergoline PIS2M2 Metergoline PIS4M1 Metergoline PIS4M1 Metergoline PIS1M1 Metergoline PIS2M1 Metergoline PIS1M2 Urinary Excretion and/or Bile duct Excretion