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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Scopolamine Scopolamine Scopolamine PIIS2M1 Scopolamine PIIS2M1 Scopolamine PIIS4M1 Scopolamine PIIS4M1 Scopolamine PIS1M1 Scopolamine PIS2M1 Scopolamine PIS1M2 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Scopolamine undergoes metabolism to give Scopolamine PIS1M1, Scopolamine PIS1M2, Scopolamine PIS1M3, Scopolamine PIS1M4 and Scopolamine PIS2M1. Endoplasmic Reticulum Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Scopolamine Scopolamine Scopolamine PIIS2M1 Scopolamine PIIS2M1 Scopolamine PIIS4M1 Scopolamine PIIS4M1 Scopolamine PIS1M1 Scopolamine PIS2M1 Scopolamine PIS1M2 Urinary Excretion and/or Bile duct Excretion