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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Troleandomycin Troleandomycin Troleandomycin PIS2M1 Troleandomycin PIS2M1 Troleandomycin PIS4M1 Troleandomycin PIS4M1 Troleandomycin PIS1M1 Troleandomycin PIS2M2 Troleandomycin PIS1M2 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Troleandomycin undergoes metabolism to give Troleandomycin PIS1M1, Troleandomycin PIS1M2, Troleandomycin PIS1M3, Troleandomycin PIS1M4 and Troleandomycin PIS2M1. Endoplasmic Reticulum Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Troleandomycin Troleandomycin Troleandomycin PIS2M1 Troleandomycin PIS2M1 Troleandomycin PIS4M1 Troleandomycin PIS4M1 Troleandomycin PIS1M1 Troleandomycin PIS2M2 Troleandomycin PIS1M2 Urinary Excretion and/or Bile duct Excretion