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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Ambrisentan Ambrisentan Ambrisentan PIS2M1 Ambrisentan PIS2M1 Ambrisentan PIS4M1 Ambrisentan PIS4M1 Ambrisentan PIS1M2 Ambrisentan PIS2M2 Ambrisentan PIS1M1 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Ambrisentan undergoes metabolism to give Ambrisentan PIS1M1, Ambrisentan PIS1M2, Ambrisentan PIS1M3, Ambrisentan PIS1M4 and Ambrisentan PIS2M1. Endoplasmic Reticulum Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Ambrisentan Ambrisentan Ambrisentan PIS2M1 Ambrisentan PIS2M1 Ambrisentan PIS4M1 Ambrisentan PIS4M1 Ambrisentan PIS1M2 Ambrisentan PIS2M2 Ambrisentan PIS1M1 Urinary Excretion and/or Bile duct Excretion