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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Aminophenazone Aminophenazone Aminophenazone PIS2M1 Aminophenazone PIS2M1 Aminophenazone PIS4M1 Aminophenazone PIS4M1 Aminophenazone PIS1M2 Aminophenazone PIS2M2 Aminophenazone PIS1M1 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Aminophenazone undergoes metabolism to give Aminophenazone PIS1M1, Aminophenazone PIS1M2, Aminophenazone PIS1M3, Aminophenazone PIS1M4 and Aminophenazone PIS2M1. Endoplasmic Reticulum Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Aminophenazone Aminophenazone Aminophenazone PIS2M1 Aminophenazone PIS2M1 Aminophenazone PIS4M1 Aminophenazone PIS4M1 Aminophenazone PIS1M2 Aminophenazone PIS2M2 Aminophenazone PIS1M1 Urinary Excretion and/or Bile duct Excretion