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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cyclobenzaprine Cyclobenzaprine Cyclobenzaprine PIS2M2 Cyclobenzaprine PIS2M2 Cyclobenzaprine PIS4M1 Cyclobenzaprine PIS4M1 Cyclobenzaprine PIS1M2 Cyclobenzaprine PIS2M1 Cyclobenzaprine PIS1M1 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Cyclobenzaprine undergoes metabolism to give Cyclobenzaprine PIS1M1, Cyclobenzaprine PIS1M2, Cyclobenzaprine PIS1M3, Cyclobenzaprine PIS1M4 and Cyclobenzaprine PIS2M1. Endoplasmic Reticulum Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Cyclobenzaprine Cyclobenzaprine Cyclobenzaprine PIS2M2 Cyclobenzaprine PIS2M2 Cyclobenzaprine PIS4M1 Cyclobenzaprine PIS4M1 Cyclobenzaprine PIS1M2 Cyclobenzaprine PIS2M1 Cyclobenzaprine PIS1M1 Urinary Excretion and/or Bile duct Excretion