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Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Amobarbital Amobarbital Amobarbital PIS2M1 Amobarbital PIS2M1 Amobarbital PIS1M3 Amobarbital PIS1M3 Amobarbital PIS2M2 Amobarbital PIS2M2 Amobarbital PIS1M1 Amobarbital PIS1M2 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Amobarbital undergoes metabolism to give Amobarbital PIS1M1, Amobarbital PIS1M2, Amobarbital PIS1M3, Amobarbital PIS1M4 and Amobarbital PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Amobarbital Amobarbital Amobarbital PIS2M1 Amobarbital PIS2M1 Amobarbital PIS1M3 Amobarbital PIS1M3 Amobarbital PIS2M2 Amobarbital PIS2M2 Amobarbital PIS1M1 Amobarbital PIS1M2 Urinary Excretion and/or Bile duct Excretion