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Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Plazomicin Plazomicin Plazomicin PIS2M1 Plazomicin PIS2M1 Plazomicin PIS1M3 Plazomicin PIS1M3 Plazomicin PIS2M2 Plazomicin PIS2M2 Plazomicin PIS1M1 Plazomicin PIS1M2 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Plazomicin undergoes metabolism to give Plazomicin PIS1M1, Plazomicin PIS1M2, Plazomicin PIS1M3, Plazomicin PIS1M4 and Plazomicin PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Plazomicin Plazomicin Plazomicin PIS2M1 Plazomicin PIS2M1 Plazomicin PIS1M3 Plazomicin PIS1M3 Plazomicin PIS2M2 Plazomicin PIS2M2 Plazomicin PIS1M1 Plazomicin PIS1M2 Urinary Excretion and/or Bile duct Excretion