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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 3A4 Irbesartan Irbesartan Irbesartan PIS1M2 Irbesartan PIIS2M1 Irbesartan PIIS2M1 Irbesartan PIS2M1 Irbesartan PIS2M1 Irbesartan PIS1M3 Irbesartan PIS1M3 Irbesartan PIS1M1 Irbesartan PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Heme Heme Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Irbesartan undergoes metabolism to give Irbesartan PIS1M1, Irbesartan PIS1M2, Irbesartan PIS1M3, Irbesartan PIS1M4 and Irbesartan PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP1A2 CYP3A4 CYP3A4 CYP1A2 CYP3A4 CYP3A4 Irbesartan Irbesartan Irbesartan PIS1M2 Irbesartan PIIS2M1 Irbesartan PIIS2M1 Irbesartan PIS2M1 Irbesartan PIS2M1 Irbesartan PIS1M3 Irbesartan PIS1M3 Irbesartan PIS1M1 Irbesartan PIS1M2 Urinary Excretion and/or Bile duct Excretion