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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Buspirone Buspirone Buspirone PIS1M4 Buspirone PIS1M3 Buspirone PIS1M3 Buspirone PIS2M2 Buspirone PIS2M2 Buspirone PIS2M1 Buspirone PIS2M1 Buspirone PIS1M1 Buspirone PIS1M4 Buspirone PIS1M2 Heme Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Buspirone undergoes metabolism to give Buspirone PIS1M1, Buspirone PIS1M2, Buspirone PIS1M3, Buspirone PIS1M4, Buspirone PIS1M5 and Buspirone PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Buspirone Buspirone Buspirone PIS1M4 Buspirone PIS1M3 Buspirone PIS1M3 Buspirone PIS2M2 Buspirone PIS2M2 Buspirone PIS2M1 Buspirone PIS2M1 Buspirone PIS1M1 Buspirone PIS1M4 Buspirone PIS1M2 Urinary Excretion and/or Bile duct Excretion