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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cetrimonium Cetrimonium Cetrimonium PIS1M4 Cetrimonium PIS1M3 Cetrimonium PIS1M3 Cetrimonium PIS2M2 Cetrimonium PIS2M2 Cetrimonium PIS2M1 Cetrimonium PIS2M1 Cetrimonium PIS1M1 Cetrimonium PIS1M4 Cetrimonium PIS1M2 Heme Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Cetrimonium undergoes metabolism to give Cetrimonium PIS1M1, Cetrimonium PIS1M2, Cetrimonium PIS1M3, Cetrimonium PIS1M4, Cetrimonium PIS1M5 and Cetrimonium PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Cetrimonium Cetrimonium Cetrimonium PIS1M4 Cetrimonium PIS1M3 Cetrimonium PIS1M3 Cetrimonium PIS2M2 Cetrimonium PIS2M2 Cetrimonium PIS2M1 Cetrimonium PIS2M1 Cetrimonium PIS1M1 Cetrimonium PIS1M4 Cetrimonium PIS1M2 Urinary Excretion and/or Bile duct Excretion