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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Mianserin Mianserin Mianserin PIS1M4 Mianserin PIS1M3 Mianserin PIS1M3 Mianserin PIS2M1 Mianserin PIS2M1 Mianserin PIS2M2 Mianserin PIS2M2 Mianserin PIS1M1 Mianserin PIS1M4 Mianserin PIS1M2 Heme Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Mianserin undergoes metabolism to give Mianserin PIS1M1, Mianserin PIS1M2, Mianserin PIS1M3, Mianserin PIS1M4, Mianserin PIS1M5 and Mianserin PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Mianserin Mianserin Mianserin PIS1M4 Mianserin PIS1M3 Mianserin PIS1M3 Mianserin PIS2M1 Mianserin PIS2M1 Mianserin PIS2M2 Mianserin PIS2M2 Mianserin PIS1M1 Mianserin PIS1M4 Mianserin PIS1M2 Urinary Excretion and/or Bile duct Excretion