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Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Lapatinib Lapatinib Lapatinib PIS2M3 Lapatinib PIS2M3 Lapatinib PIS2M1 Lapatinib PIS2M1 Lapatinib PIS2M2 Lapatinib PIS2M2 Lapatinib PIS1M1 Lapatinib PIS1M3 Lapatinib PIS1M2 Heme Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Lapatinib undergoes metabolism to give Lapatinib PIS1M1, Lapatinib PIS1M2, Lapatinib PIS1M3, Lapatinib PIS1M4, Lapatinib PIS1M5 and Lapatinib PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Lapatinib Lapatinib Lapatinib PIS2M3 Lapatinib PIS2M3 Lapatinib PIS2M1 Lapatinib PIS2M1 Lapatinib PIS2M2 Lapatinib PIS2M2 Lapatinib PIS1M1 Lapatinib PIS1M3 Lapatinib PIS1M2 Urinary Excretion and/or Bile duct Excretion