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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 3A4 Clemastine Clemastine Clemastine PIS1M3 Clemastine PIS2M2 Clemastine PIS2M2 Clemastine PIS2M1 Clemastine PIS2M1 Clemastine PIS2M3 Clemastine PIS2M3 Clemastine PIS1M1 Clemastine PIS1M3 Clemastine PIS1M2 Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Heme Heme Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Clemastine undergoes metabolism to give Clemastine PIS1M1, Clemastine PIS1M2, Clemastine PIS1M3, Clemastine PIS1M4, Clemastine PIS1M5 and Clemastine PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP1A2 CYP3A4 CYP3A4 CYP1A2 CYP3A4 Clemastine Clemastine Clemastine PIS1M3 Clemastine PIS2M2 Clemastine PIS2M2 Clemastine PIS2M1 Clemastine PIS2M1 Clemastine PIS2M3 Clemastine PIS2M3 Clemastine PIS1M1 Clemastine PIS1M3 Clemastine PIS1M2 Urinary Excretion and/or Bile duct Excretion