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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Mitoxantrone Mitoxantrone Midodrine PIS2M1 Midodrine PIS2M1 Mitoxantrone PIS2M3 Mitoxantrone PIS2M3 Mitoxantrone PIS1M4 Mitoxantrone PIS1M4 Mitoxantrone PIS2M2 Mitoxantrone PIS2M2 Mitoxantrone PIS1M1 Mitoxantrone PIS1M3 Mitoxantrone PIS1M2 Heme Heme Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Mitoxantrone undergoes metabolism to give Mitoxantrone PIS1M1, Mitoxantrone PIS1M2, Mitoxantrone PIS1M3, Mitoxantrone PIS1M4, Mitoxantrone PIS1M5, Mitoxantrone PIS1M6 and Mitoxantrone PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Mitoxantrone Mitoxantrone Midodrine PIS2M1 Midodrine PIS2M1 Mitoxantrone PIS2M3 Mitoxantrone PIS2M3 Mitoxantrone PIS1M4 Mitoxantrone PIS1M4 Mitoxantrone PIS2M2 Mitoxantrone PIS2M2 Mitoxantrone PIS1M1 Mitoxantrone PIS1M3 Mitoxantrone PIS1M2 Urinary Excretion and/or Bile duct Excretion