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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Moclobemide Moclobemide Midodrine PIS2M1 Midodrine PIS2M1 Moclobemide PIS2M2 Moclobemide PIS2M2 Moclobemide PIS1M4 Moclobemide PIS1M4 Moclobemide PIS2M1 Moclobemide PIS2M1 Moclobemide PIS1M1 Moclobemide PIS1M3 Moclobemide PIS1M2 Heme Heme Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Moclobemide undergoes metabolism to give Moclobemide PIS1M1, Moclobemide PIS1M2, Moclobemide PIS1M3, Moclobemide PIS1M4, Moclobemide PIS1M5, Moclobemide PIS1M6 and Moclobemide PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Moclobemide Moclobemide Midodrine PIS2M1 Midodrine PIS2M1 Moclobemide PIS2M2 Moclobemide PIS2M2 Moclobemide PIS1M4 Moclobemide PIS1M4 Moclobemide PIS2M1 Moclobemide PIS2M1 Moclobemide PIS1M1 Moclobemide PIS1M3 Moclobemide PIS1M2 Urinary Excretion and/or Bile duct Excretion