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protein kinase C beta Nuclear factor NF-kappa-B p105 subunit Gq protein signaling cascade Phospholipase C Inositol 1,4,5- trisphosphate receptor type 1 Protein kinase C alpha type Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Histamine H1 receptor Inositol 1,4,5- trisphosphate Histamine Ziprasidone Ca+ Ca+ Ziprasidone Phosphatidylinositol 4,5-bisphosphate Calcium ↑ Mediator Release Diacylglycerol ↑ Pro-inflammatory Cytokines, Cell Adhesion Molecules, Chemotactic Factors Mast Cells Release Histamine Ca+ Calcium Nucleus ↑ Antigen Presentation ↓ Mast Cell Stabilization Endoplamic Reticulum There is an overall decrease in calcium levels in the cytosol caused by the inhibition of the Gq signaling cascade Cytosol T Cell Ziprasidone antagonizes Histamine H1 receptors in endothelial cells, preventing histamine from activating the receptor T Cell
Melanosome Endoplasmic Reticulum Nucleus PRKCB NFKB1 GNAQ PLCB1 ITPR1 PRKCA CACNA1A CACNB1 CACNA2D2 HRH1 Inositol 1,4,5- trisphosphate Histamine Ziprasidone Calcium Calcium Ziprasidone Phosphatidylinositol 4,5-bisphosphate Diacylglycerol Mast Cells Release Histamine Calcium
PRKCB NFKB1 GNAQ PLCB1 ITPR1 PRKCA CACNA1A CACNB1 CACNA2D2 HRH1 Inotp Hsm Ziprasi Ca+ Ca+ Ziprasi P45P Ca2+ ↑ Mediator Release Diacylg ↑ Pro-inflammatory Cytokines, Cell Adhesion Molecules, Chemotactic Factors M C R H Ca+ Ca2+ Nucleus ↑ Antigen Presentation ↓ Mast Cell Stabilization Endoplamic Reticulum There is an overall decrease in calcium levels in the cytosol caused by the inhibition of the Gq signaling cascade Cytosol T Cell Ziprasidone antagonizes Histamine H1 receptors in endothelial cells, preventing histamine from activating the receptor T Cell
Melanosome Endoplasmic Reticulum Nucleus PRKCB NFKB1 GNAQ PLCB1 ITPR1 PRKCA CACNA1A CACNB1 CACNA2D2 HRH1 Inotp Hsm Ziprasi Ca2+ Ca2+ Ziprasi P45P Diacylg M C R H Ca2+