Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
hedgehog
Homo sapiens
Signaling Pathway
References
hedgehog References
Panakova D, Sprong H, Marois E, Thiele C, Eaton S: Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature. 2005 May 5;435(7038):58-65. doi: 10.1038/nature03504.
Pubmed: 15875013
Deshpande I, Liang J, Hedeen D, Roberts KJ, Zhang Y, Ha B, Latorraca NR, Faust B, Dror RO, Beachy PA, Myers BR, Manglik A: Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. Nature. 2019 Jul;571(7764):284-288. doi: 10.1038/s41586-019-1355-4. Epub 2019 Jul 1.
Pubmed: 31263273
Zahreddine HA, Culjkovic-Kraljacic B, Assouline S, Gendron P, Romeo AA, Morris SJ, Cormack G, Jaquith JB, Cerchietti L, Cocolakis E, Amri A, Bergeron J, Leber B, Becker MW, Pei S, Jordan CT, Miller WH, Borden KL: The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation. Nature. 2014 Jul 3;511(7507):90-3. doi: 10.1038/nature13283. Epub 2014 May 28.
Pubmed: 24870236
Zhao Y, Tong C, Jiang J: Hedgehog regulates smoothened activity by inducing a conformational switch. Nature. 2007 Nov 8;450(7167):252-8. doi: 10.1038/nature06225. Epub 2007 Oct 24.
Pubmed: 17960137
Marigo V, Davey RA, Zuo Y, Cunningham JM, Tabin CJ: Biochemical evidence that patched is the Hedgehog receptor. Nature. 1996 Nov 14;384(6605):176-9. doi: 10.1038/384176a0.
Pubmed: 8906794
Highlighted elements will appear in red.
Highlight Compounds
No Compounds Present
Highlight Proteins
No Proteins Present
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
No Compounds Present
Visualize Protein Data
No Proteins Present
Clear
Settings