Bacteria such as Comamonas testosteroni plays a crucial role in degradation of 4-hydroxyphthalate, an environmental pollutant. 4-hydroxyphthalate is degraded by Comamonas testosterone, yielding precursors used in the benzoate degradation pathway to yield carbon and energy, which is vital for the bacteria's growth and survival. Although the precise mechanisms of 4-hydroxyphthalate uptake, potentially facilitated by MFS transporters, are not fully understood, the subsequent enzymatic breakdown within the cell yields 4-Carboxy-2-hydroxymuconate semialdehyde, an essential intermediate for the benzoate degradation pathway.

4-Hydroxyphthalate degradation References