PathWhiz

Pathway Description

Pyocyanine biosynthesis

Pseudomonas aeruginosa

Metabolic Pathway

Pyocyanin biosynthesis involves a sequence of enzymatic activities that occur within the bacterial cell. The precursor molecule for pyocyanin production, chorismate, is produced from major metabolic pathways within the bacterial cell, such as phenylalanine, tyrosine, and tryptophan biosynthesis. These precursors are enzymatically transformed to pyocyanin by a sequence of processes facilitated by particular enzymes, including phenazine biosynthesis proteins (PhzE,D, and F). These enzymes promote the condensation, cyclization, and oxidation events essential for the synthesis of pyocyanin, which plays an important role in the virulence and pathogenicity.

References

Pyocyanine biosynthesis References

Mudaliar, S.B. and Bharath Prasad, A.S., 2024. A biomedical perspective of pyocyanin from Pseudomonas aeruginosa: its applications and challenges. World Journal of Microbiology and Biotechnology, 40(3), pp.1-23.

Kanehisa, M., 2002, November. The KEGG database. In ‘In silico’simulation of biological processes: Novartis Foundation Symposium 247 (Vol. 247, pp. 91-103). Chichester, UK: John Wiley & Sons, Ltd.

UniProt Consortium, 2019. UniProt: a worldwide hub of protein knowledge. Nucleic acids research, 47(D1), pp.D506-D515.

Kim, S., Thiessen, P.A., Bolton, E.E., Chen, J., Fu, G., Gindulyte, A., Han, L., He, J., He, S., Shoemaker, B.A. and Wang, J., 2016. PubChem substance and compound databases. Nucleic acids research, 44(D1), pp.D1202-D1213.

de Matos, P., Adams, N., Hastings, J., Moreno, P. and Steinbeck, C., 2012. A database for chemical proteomics: ChEBI. Chemical Proteomics: Methods and Protocols, pp.273-296.

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		5,10-Dihydrophenazine-1-carboxylate
		(10aS)-10,10a-Dihydrophenazine-1-carboxylate
		(1R,10aS)-1,4,10,10a-Tetrahydrophenazine-1-carboxylate
		(1R,5aS,6R)-4a-Hydroxy-1,4,4a,5,5a,6,9,10a-octahydrophenazine-1,6-dicarboxylate
		(1R,6R)-1,4,5,5a,6,9-Hexahydrophenazine-1,6-dicarboxylate
		(1R,6S)-6-Amino-5-oxocyclohex-2-ene-1-carboxylate
		(5S,6S)-6-Amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate
		2-Amino-2-deoxyisochorismate
		5-Methylphenazine-1-carboxylate
		Carbon dioxide
		Chorismate
		FAD
		FMN
		Hydrogen Ion
		Hydrogen peroxide
		L-Glutamic acid
		L-Glutamine
		NAD
		NADH
		Oxygen
		Phenazine-1-carboxylate
		Pyocyanine
		Pyruvic acid
		S-Adenosylhomocysteine
		S-Adenosylmethionine
		Water

Visualize Protein Data

		5-methylphenazine-1-carboxylate 1-monooxygenase
		Phenazine biosynthesis protein PhzA2
		Phenazine biosynthesis protein PhzD1
		Phenazine biosynthesis protein PhzD2
		Phenazine biosynthesis protein PhzE
		Phenazine-1-carboxylate N-methyltransferase
		Probable pyridoxamine 5'-phosphate oxidase
		Trans-2,3-dihydro-3-hydroxyanthranilate isomerase

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