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Pathway Description
Biliverdin-IX-delta biosynthesis
Shewanella denitrificans
Metabolic Pathway
Biliverdin-IX-delta serves multiple roles in Shewanella denitrificans, including acting as an antioxidant to protect the cell from oxidative damage and as a signaling molecule. Biliverdin-IX-delta biosynthesis in Shewanella denitrificans is a sequence of enzymatic activities that transform heme, which is acquired from numerous processes such as glutamate metabolism, into biliverdin-IX-delta. Heme oxygenase catalyzes oxidation of heme, integrating oxygen and producing biliverdin-IX-delta, CO, and Fe2+.
References
Biliverdin-IX-delta biosynthesis References
https://www.genome.jp/pathway/sdn00860
Robinson, E.A., Frankenberg-Dinkel, N., Xue, F., Wilks, A., 2021. Recombinant Production of Biliverdin IXβ and δ Isomers in the T7 Promoter Compatible Escherichia coli Nissle. Frontiers in Microbiology 12.. https://doi.org/10.3389/fmicb.2021.787609
Seok, J., Ko, Y.J., Lee, M.-E., Hyeon, J.E., Han, S.O., 2019. Systems metabolic engineering of Corynebacterium glutamicum for the bioproduction of biliverdin via protoporphyrin independent pathway. Journal of Biological Engineering 13.. https://doi.org/10.1186/s13036-019-0156-5
Wegiel, B., Nemeth, Z., Correa-Costa, M., Bulmer, A.C., Otterbein, L.E., 2014. Heme Oxygenase-1: A Metabolic Nike. Antioxidants & Redox Signaling 20, 1709–1722.. https://doi.org/10.1089/ars.2013.5667
https://www.ebi.ac.uk/chebi/init.do
https://pubchem.ncbi.nlm.nih.gov/
https://www.uniprot.org/
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