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Pathway Description
Naphthalene degradation
Pseudomonas putida
Metabolic Pathway
Naphthalene degradation involves a series of enzymatic reactionsin which bacteria use as both a carbon and energy source. Naphthalene, a polycyclic aromatic hydrocarbon (PAH), enters bacterial cells by passive diffusion across the cell membrane due to its hydrophobicity. Once within the cell, naphthalene is activated by the enzyme naphthalene dioxygenase, which produces cis-1,2-dihydroxynaphthalene. This intermediate is further metabolized by a series of enzymatic reactions, including ring cleavage, hydroxylation, and oxidation, to produce metabolites such as Gentisate and Catechol, which enter the Tyrosine metabolism and benzoate degradation pathways for energy generation and biosynthesis.
References
Naphthalene degradation References
Kanehisa, M., 2002, November. The KEGG database. In ‘In silico’simulation of biological processes: Novartis Foundation Symposium 247 (Vol. 247, pp. 91-103). Chichester, UK: John Wiley & Sons, Ltd.
de Matos, P., Adams, N., Hastings, J., Moreno, P. and Steinbeck, C., 2012. A database for chemical proteomics: ChEBI. Chemical Proteomics: Methods and Protocols, pp.273-296.
Kim, S., Thiessen, P.A., Bolton, E.E., Chen, J., Fu, G., Gindulyte, A., Han, L., He, J., He, S., Shoemaker, B.A. and Wang, J., 2016. PubChem substance and compound databases. Nucleic acids research, 44(D1), pp.D1202-D1213.
UniProt Consortium, 2019. UniProt: a worldwide hub of protein knowledge. Nucleic acids research, 47(D1), pp.D506-D515.
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