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Pathway Description
Ectoine degradation
Serratia sp. FS14
Metabolic Pathway
Ectoine degradation utilizes ectoine, which is produced by bacteria to combat osmotic stress. Ectoine is catabolized in a sequence of enzymatic reactions to produce L-Aspartate or intermediates for Lysine production. The first step involves ectoine hydrolysis to N(alpha)-Acetyl-L-2,4-diaminobutyrate by ectoine hydrolase. N(alpha)-Acetyl-L-2,4-diaminobutyrate is then further degraded, resulting in intermediates that enter primary metabolic pathways for energy generation and biosynthesis of products such as amino acids.
References
Ectoine degradation References
Ma, Z., Wu, C., Zhu, L., Chang, R., Ma, W., Deng, Y. and Chen, X., 2022. Bioactivity profiling of the extremolyte ectoine as a promising protectant and its heterologous production. 3 Biotech, 12(12), p.331.
Kanehisa, M., 2002, November. The KEGG database. In ‘In silico’simulation of biological processes: Novartis Foundation Symposium 247 (Vol. 247, pp. 91-103). Chichester, UK: John Wiley & Sons, Ltd.
de Matos, P., Adams, N., Hastings, J., Moreno, P. and Steinbeck, C., 2012. A database for chemical proteomics: ChEBI. Chemical Proteomics: Methods and Protocols, pp.273-296.
Kim, S., Thiessen, P.A., Bolton, E.E., Chen, J., Fu, G., Gindulyte, A., Han, L., He, J., He, S., Shoemaker, B.A. and Wang, J., 2016. PubChem substance and compound databases. Nucleic acids research, 44(D1), pp.D1202-D1213.
UniProt Consortium, 2019. UniProt: a worldwide hub of protein knowledge. Nucleic acids research, 47(D1), pp.D506-D515.
Reshetnikov AS, Rozova ON, Trotsenko YA, But SY, Khmelenina VN, Mustakhimov II: Ectoine degradation pathway in halotolerant methylotrophs. PLoS One. 2020 Apr 30;15(4):e0232244. doi: 10.1371/journal.pone.0232244. eCollection 2020.
Pubmed: 32353000
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