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Type I polyketide synthase AVES 1 Cytochrome P450 hydroxylase C-5 ketoreductase C5-O- methyltransferase dTDP-L-oleandrose transferase (Glycosyltransferase) dTDP-L-oleandrose transferase (Glycosyltransferase) dTDP 2- Methylbutyryl- CoA Methylmalonyl-CoA Malonyl-CoA NADPH H+ 6,8a-Seco-6,8a- deoxy-5- oxoavermectin ''1a'' aglycone CO2 CoA H2O NADP NADPH O2 5-Oxoavermectin ''1a'' aglycone NADP H2O NADPH H+ Avermectin B1a aglycone NADP S- Adenosylmethionine Avermectin A1a aglycone S- Adenosylhomocysteine dTDP-L-oleandrose Avermectin A1a monosaccharide dTDP-L-oleandrose Avermectin A1a dTDP Isoleucine Degradation Gram-Negative Cell Periplasmic Space Outer Membrane Inner Membrane Cytoplasm Plasmid
aveA1 aveE aveF aveD aveBI aveBI dTDP 2- Methylbutyryl- CoA Methylmalonyl-CoA Malonyl-CoA NADPH Hydrogen Ion 6,8a-Seco-6,8a- deoxy-5- oxoavermectin ''1a'' aglycone Carbon dioxide Coenzyme A Water NADP NADPH Oxygen 5-Oxoavermectin ''1a'' aglycone NADP Water NADPH Hydrogen Ion Avermectin B1a aglycone NADP S- Adenosylmethionine Avermectin A1a aglycone S- Adenosylhomocysteine dTDP-L-oleandrose Avermectin A1a monosaccharide dTDP-L-oleandrose Avermectin A1a dTDP Isoleucine Degradation
aveA1 aveE aveF aveD aveBI aveBI dTDP 2IbuCoA Mal-CoA MalyCoA NADPH H+ 6-S-6-d CO2 CoA H2O NADP NADPH O2 5-O ' a NADP H2O NADPH H+ A B a NADP SAMe Av A1 a SAH dT-L-ol Av A1 m dT-L-ol Ave A1a dTDP PW273333 Gram-Negative Cell Periplasmic Space Outer Membrane Inner Membrane Cytoplasm Plasmid
aveA1 aveE aveF aveD aveBI aveBI dTDP 2IbuCoA Mal-CoA MalyCoA NADPH H+ 6-S-6-d CO2 CoA H2O NADP NADPH O2 5-O ' a NADP H2O NADPH H+ A B a NADP SAMe Av A1 a SAH dT-L-ol Av A1 m dT-L-ol Ave A1a dTDP PW273333