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Type I polyketide synthase AVES 1 Cytochrome P450 hydroxylase C-5 ketoreductase dTDP-L-oleandrose transferase (Glycosyltransferase) dTDP-L-oleandrose transferase (Glycosyltransferase) 2- Methylbutyryl- CoA Methylmalonyl-CoA Malonyl-CoA NADPH H+ 6,8a-Seco-6,8a- deoxy-5- oxoavermectin ''2a'' aglycone CO2 CoA H2O NADP NADPH O2 H2O NADP 5-Oxoavermectin ''2a'' aglycone NADPH H+ NADP Avermectin B2a aglycone dTDP-L-oleandrose dTDP Avermectin B2a monosaccharide dTDP-L-oleandrose dTDP Avermectin B2a Isoleucine Degradation Gram-Negative Cell Periplasm Outer Membrane Inner Membrane Cytoplasm Plasmid
aveA1 aveE aveF aveBI aveBI 2- Methylbutyryl- CoA Methylmalonyl-CoA Malonyl-CoA NADPH Hydrogen Ion 6,8a-Seco-6,8a- deoxy-5- oxoavermectin ''2a'' aglycone Carbon dioxide Coenzyme A Water NADP NADPH Oxygen Water NADP 5-Oxoavermectin ''2a'' aglycone NADPH Hydrogen Ion NADP Avermectin B2a aglycone dTDP-L-oleandrose dTDP Avermectin B2a monosaccharide dTDP-L-oleandrose dTDP Avermectin B2a Isoleucine Degradation
aveA1 aveE aveF aveBI aveBI 2IbuCoA Mal-CoA MalyCoA NADPH H+ 6-S-6-d CO2 CoA H2O NADP NADPH O2 H2O NADP 5-O ' a NADPH H+ NADP Av B2 a dT-L-ol dTDP Av B2 m dT-L-ol dTDP Ave B2a PW273333 Gram-Negative Cell Periplasm Outer Membrane Inner Membrane Cytoplasm Plasmid
aveA1 aveE aveF aveBI aveBI 2IbuCoA Mal-CoA MalyCoA NADPH H+ 6-S-6-d CO2 CoA H2O NADP NADPH O2 H2O NADP 5-O ' a NADPH H+ NADP Av B2 a dT-L-ol dTDP Av B2 m dT-L-ol dTDP Ave B2a PW273333