Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChEBI CHEBI 16932
type: UnificationXref
id: CHEBI:16932
db: ChEBI

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Reference/ChEBI CHEBI 15966
type: UnificationXref
id: CHEBI:15966
db: ChEBI

L-Glutamine
type: SmallMolecule
cellular location: Inner Membrane
entity reference: L-Glutamine

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/PW C040828 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetylmuramoyl-L-alanine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

direct_interaction
type: InteractionVocabulary

SubPathwayInteraction383667
type: Interaction
name: SubPathwayReaction
name: SubPathway383667Reaction
participant: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

SubPathwayInteraction383666
type: Interaction
name: SubPathwayReaction
name: SubPathway383666Reaction
participant: UDP-N-acetylmuraminate

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Reference/BioCyc GAMMA-GLUTAMYL-D-GLUTAMATE
type: UnificationXref
id: GAMMA-GLUTAMYL-D-GLUTAMATE
db: BioCyc

Compound/PW C000500 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 6992096
type: UnificationXref
id: 6992096
db: PubChem-compound

Interaction6326
type: MolecularInteraction
interaction type: direct_interaction
name: Adenosine tetraphosphate inhibits glutaminase
participant: Unknown
participant: Adenosine tetraphosphate

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Compound/PW C001034 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Ammonium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0041827
xref: Reference/CAS 14798-03-9
xref: Reference/PubChem-compound 16741146
xref: Reference/KEGG Compound C01342
xref: Reference/ChEBI CHEBI 28938
xref: Reference/ChemSpider 218
chemical formula: H4N
molecular weight: 18.034374
structure: ChemicalStructure/PW C022608

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Compound/PW C001849 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glutamic acid
stoichiometric coefficient: 1.0

Compound/PW C000035/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00217
type: UnificationXref
id: C00217
db: KEGG Compound

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

ReactionCoupledTransport5123
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C000500 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Inner Membrane/Stoichiometry/1.0
right: Phosphate
right: L-Glutamine
right: Adenosine diphosphate
right: Hydrogen Ion
spontaneous: false
left: Water
left: Adenosine triphosphate
left: L-Glutamine
name: Adenosine triphosphate + L-Glutamine + Water → Adenosine diphosphate + Hydrogen Ion + L-Glutamine + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCoupledTransport5125
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Inner Membrane/Stoichiometry/1.0
right: Phosphate
right: L-Glutamic acid
right: Adenosine diphosphate
right: Hydrogen Ion
spontaneous: false
left: Water
left: Adenosine triphosphate
left: L-Glutamic acid
name: Adenosine triphosphate + L-Glutamic acid + Water → Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Ammonia
type: SmallMolecule
entity reference: Ammonia

glutamine ABC transporter
type: Complex
component stoichiometry: Protein/28275 Inner Membrane/Stoichiometry/2.0
cellular location: Inner Membrane
component: Unknown

Ammonium
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Ammonium

Compound/PW C001849/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glutamic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 1136
type: UnificationXref
id: 1136
db: ChemSpider

Unknown
type: Protein
entity reference: Unknown

Ammonia
type: SmallMolecule
cellular location: Cytosol
entity reference: Ammonia

Reference/ChEBI CHEBI 58000
type: UnificationXref
id: CHEBI:58000
db: ChEBI

Reference/ChemSpider 5735
type: UnificationXref
id: 5735
db: ChemSpider

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

D-Glutamine and D-Glutamate Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/5561199
pathway order: PathwayInteraction/6326
pathway order: PathwayEnzymeReaction/5561197
pathway order: PathwaySubPathway/383666
pathway order: PathwayEnzymeReaction/5561198
pathway order: PathwayEnzymeReaction/5561195
pathway order: PathwayEnzymeReaction/5561196
pathway order: PathwaySubPathway/383667
pathway order: PathwayEnzymeReaction/5561193
pathway order: PathwayEnzymeReaction/5561194
pathway order: PathwayEnzymeReaction/5561192
pathway order: PathwayTransport/5561200
pathway order: PathwayTransport/5561201
pathway component: Reaction603907
pathway component: ReactionCatalysis597736
pathway component: ReactionCoupledTransportCatalysis5185
pathway component: 3.5.1.2
pathway component: 6.3.2.9
pathway component: Amino Sugar and Nucleotide Sugar Metabolism I
pathway component: ReactionCatalysis597732
pathway component: ReactionCatalysis597733
pathway component: ReactionCatalysis597734
pathway component: ReactionCoupledTransportCatalysis5187
pathway component: TransportCatalysis25096
pathway component: ReactionCatalysis597735
pathway component: TransportCatalysis25095
pathway component: 6.3.2.8
pathway component: ReactionCatalysis597731
pathway component: Interaction6326
pathway component: ReactionCoupledTransport5123
pathway component: ReactionCoupledTransport5125
pathway component: SubPathway
pathway component: Transport42617
pathway component: Transport42616
pathway component: 5.1.1.3
xref: Reference/SMPDB SMP0384071
xref: Reference/PathWhiz PW392338
organism: Escherichia coli O103:H2 str. 12009

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/GENE ONTOLOGY GO 0070258
type: UnificationXref
id: GO:0070258
db: GENE ONTOLOGY

Unknown
type: Protein
cellular location: Inner Membrane
entity reference: Unknown

Amino Sugar and Nucleotide Sugar Metabolism I
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway383666
pathway component: SubPathwayInteraction383666
xref: Reference/PathWhiz PW000886
xref: Reference/SMPDB SMP0000905
name: SubPathway

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

D-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glutamic acid

Reference/ChEBI CHEBI 16977
type: UnificationXref
id: CHEBI:16977
db: ChEBI

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/ChemSpider 218
type: UnificationXref
id: 218
db: ChemSpider

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
type: SmallMolecule
entity reference: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
name: SubPathwayInput

Compound/PW C022608 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonium
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Hydrogen Ion

D-Glutamic acid
type: SmallMoleculeReference
xref: Reference/CAS 6893-26-1
xref: Reference/KEGG Compound C00217
xref: Reference/ChemSpider 21814
xref: Reference/ChEBI CHEBI 15966
xref: Reference/HMDB HMDB0003339
xref: Reference/PubChem-compound 23327
xref: Reference/BioCyc GAMMA-GLUTAMYL-D-GLUTAMATE
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C001849

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

ReactionCatalysis597736
type: Catalysis
controller: Unknown
controlled: 6.3.2.8
control type: ACTIVATION

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

D-glutamine
type: SmallMolecule
cellular location: Cytosol
entity reference: D-glutamine

ReactionCatalysis597732
type: Catalysis
controller: Unknown
controlled: 3.5.1.2
control type: ACTIVATION

Compound/PW C000500/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

ReactionCatalysis597733
type: Catalysis
controller: Unknown
controlled: Reaction603907
control type: ACTIVATION

ReactionCatalysis597734
type: Catalysis
controller: Unknown
controlled: 3.5.1.2
control type: ACTIVATION

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

ReactionCatalysis597735
type: Catalysis
controller: Unknown
controlled: 5.1.1.3
control type: ACTIVATION

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/BioCyc L-ALPHA-ALANINE
type: UnificationXref
id: L-ALPHA-ALANINE
db: BioCyc

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

ReactionCatalysis597731
type: Catalysis
controller: Unknown
controlled: 6.3.2.9
control type: ACTIVATION

UDP-N-acetylmuramoyl-L-alanine
type: SmallMolecule
entity reference: UDP-N-acetylmuramoyl-L-alanine

Reference/CAS 56-41-7
type: UnificationXref
id: 56-41-7
db: CAS

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070258

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Adenosine tetraphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03483
xref: Reference/ChemSpider 13390
xref: Reference/CAS 58337-43-2
xref: Reference/BioCyc CPD-607
xref: Reference/PubChem-compound 14003
xref: Reference/ChEBI CHEBI 18334
xref: Reference/HMDB HMDB0001364
chemical formula: C10H17N5O16P4
molecular weight: 586.9621
structure: ChemicalStructure/PW C001052

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Reaction603907
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000500 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C022608 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Inner Membrane/Stoichiometry/1.0
right: Phosphate
right: L-Glutamine
right: Adenosine diphosphate
right: Hydrogen Ion
spontaneous: false
left: Adenosine triphosphate
left: L-Glutamic acid
left: Ammonium
name: Adenosine triphosphate + Ammonium + L-Glutamic acid → Adenosine diphosphate + Hydrogen Ion + L-Glutamine + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCoupledTransportCatalysis5185
type: Catalysis
controller: glutamine ABC transporter
controlled: ReactionCoupledTransport5123
control type: ACTIVATION

3.5.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040827 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001849 Cytosol/Stoichiometry/1.0
right: Ammonia
right: D-Glutamic acid
spontaneous: false
EC number: 3.5.1.2
left: D-glutamine
left: Water
name: D-glutamine + Water → Ammonia + D-Glutamic acid
conversion direction: LEFT_TO_RIGHT

6.3.2.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040829/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040828/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001849/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: Adenosine diphosphate
right: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
right: Phosphate
spontaneous: false
EC number: 6.3.2.9
left: D-Glutamic acid
left: UDP-N-acetylmuramoyl-L-alanine
left: Adenosine triphosphate
name: Adenosine triphosphate + D-Glutamic acid + UDP-N-acetylmuramoyl-L-alanine → Adenosine diphosphate + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
conversion direction: LEFT_TO_RIGHT

3.5.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035/Stoichiometry/1.0
right: L-Glutamic acid
right: Ammonia
spontaneous: false
EC number: 3.5.1.2
left: Water
left: L-Glutamine
name: L-Glutamine + Water → Ammonia + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000886
type: UnificationXref
id: PW000886
db: PathWhiz

D-Glutamic acid
type: SmallMolecule
entity reference: D-Glutamic acid

ReactionCoupledTransportCatalysis5187
type: Catalysis
controller: Unknown
controlled: ReactionCoupledTransport5125
control type: ACTIVATION

Reference/KEGG Compound C01342
type: UnificationXref
id: C01342
db: KEGG Compound

Reference/ChEBI CHEBI 28938
type: UnificationXref
id: CHEBI:28938
db: ChEBI

ChemicalStructure/PW C000105
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](N)C(O)=O

Reference/PubChem-compound 5950
type: UnificationXref
id: 5950
db: PubChem-compound

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

D-glutamine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58000
xref: Reference/PubChem-compound 6992096
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C040827

Reference/ChEBI CHEBI 18334
type: UnificationXref
id: CHEBI:18334
db: ChEBI

UDP-N-acetylmuramoyl-L-alanine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16932
chemical formula: C23H36N4O20P2
molecular weight: 750.13983
structure: ChemicalStructure/PW C040828

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 3960
chemical formula: C22H32Cl2N2O4
molecular weight: 458.17392
structure: ChemicalStructure/PW C040829

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005620
type: UnificationXref
id: GO:0005620
db: GENE ONTOLOGY

Compound/PW C000095 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

5.1.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001849 Cytosol/Stoichiometry/1.0
right: D-Glutamic acid
spontaneous: false
EC number: 5.1.1.3
left: L-Glutamic acid
name: L-Glutamic acid ↔ D-Glutamic acid
conversion direction: REVERSIBLE

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Protein/28275 Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Escherichia coli O103:H2 str. 12009
type: BioSource
xref: Reference/TAXONOMY 585395

6.3.2.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C007296 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000105 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040828 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Adenosine diphosphate
right: UDP-N-acetylmuramoyl-L-alanine
spontaneous: false
EC number: 6.3.2.8
left: Adenosine triphosphate
left: L-Alanine
left: UDP-N-acetylmuraminate
name: Adenosine triphosphate + L-Alanine + UDP-N-acetylmuraminate → Adenosine diphosphate + Phosphate + UDP-N-acetylmuramoyl-L-alanine
conversion direction: LEFT_TO_RIGHT

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

UDP-N-acetylmuraminate
type: SmallMolecule
cellular location: Cytosol
entity reference: UDP-N-acetylmuraminate

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

Compound/PW C000458 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/PubChem-compound 23327
type: UnificationXref
id: 23327
db: PubChem-compound

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Adenosine triphosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Adenosine triphosphate

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Reference/CAS 6893-26-1
type: UnificationXref
id: 6893-26-1
db: CAS

Water
type: SmallMolecule
entity reference: Water

Compound/PW C007296 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetylmuraminate
stoichiometric coefficient: 1.0

Reference/ChemSpider 13390
type: UnificationXref
id: 13390
db: ChemSpider

Reference/KEGG Compound C00041
type: UnificationXref
id: C00041
db: KEGG Compound

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Phosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Phosphate

Reference/TAXONOMY 585395
type: UnificationXref
id: 585395
db: TAXONOMY

Compound/PW C000414 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/CAS 14798-03-9
type: UnificationXref
id: 14798-03-9
db: CAS

Compound/PW C000105 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Alanine
stoichiometric coefficient: 1.0

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Water
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Water

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Adenosine tetraphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine tetraphosphate

Reference/HMDB HMDB0011720
type: UnificationXref
id: HMDB0011720
db: HMDB

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Compound/PW C040828/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetylmuramoyl-L-alanine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001364
type: UnificationXref
id: HMDB0001364
db: HMDB

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

ChemicalStructure/PW C022608
type: ChemicalStructure
structure format: SMILES
structure data: [NH4+]

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/PubChem-compound 3960
type: UnificationXref
id: 3960
db: PubChem-compound

L-Glutamic acid
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: L-Glutamic acid

Compound/PW C000035 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Unknown
type: ProteinReference

Reference/HMDB HMDB0000161
type: UnificationXref
id: HMDB0000161
db: HMDB

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

UDP-N-acetylmuraminate
type: SmallMolecule
entity reference: UDP-N-acetylmuraminate
name: SubPathwayOutput

Transport42617
type: Transport
participant stoichiometry: Compound/PW C000095 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
right: L-Glutamic acid
spontaneous: false
left: Sodium
left: L-Glutamic acid
name: L-Glutamic acid (→), Sodium (→) Transport: Escherichia coli O103:H2 str. 12009, Periplasmic Space to Escherichia coli O103:H2 str. 12009, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport42616
type: Transport
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: L-Glutamic acid
spontaneous: false
left: Hydrogen Ion
left: L-Glutamic acid
name: Hydrogen Ion (→), L-Glutamic acid (→) Transport: Escherichia coli O103:H2 str. 12009, Periplasmic Space to Escherichia coli O103:H2 str. 12009, Cytosol
conversion direction: LEFT_TO_RIGHT

UDP-N-acetylmuraminate
type: SmallMoleculeReference
xref: Reference/ChemSpider 1136
xref: Reference/KEGG Compound C01050
xref: Reference/PubChem-compound 1169
xref: Reference/HMDB HMDB0011720
xref: Reference/ChEBI CHEBI 17882
chemical formula: C20H31N3O19P2
molecular weight: 679.1027
structure: ChemicalStructure/PW C007296

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

L-Alanine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00041
xref: Reference/ChemSpider 5735
xref: Reference/ChEBI CHEBI 16977
xref: Reference/BioCyc L-ALPHA-ALANINE
xref: Reference/HMDB HMDB0000161
xref: Reference/CAS 56-41-7
xref: Reference/PubChem-compound 5950
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C000105

TransportCatalysis25096
type: Catalysis
controller: Unknown
controlled: Transport42617
control type: ACTIVATION

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

L-Alanine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Alanine

TransportCatalysis25095
type: Catalysis
controller: Unknown
controlled: Transport42616
control type: ACTIVATION

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
entity reference: Phosphate

ChemicalStructure/PW C040829
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 14003
type: UnificationXref
id: 14003
db: PubChem-compound

ChemicalStructure/PW C040828
type: ChemicalStructure
structure format: SMILES

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040827
type: ChemicalStructure
structure format: SMILES
structure data: N[C@H](CCC(N)=O)C(O)=O

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Periplasmic Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005620

Compound/PW C000095 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01050
type: UnificationXref
id: C01050
db: KEGG Compound

Compound/PW C040827 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-glutamine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Reference/PathWhiz PW392338
type: UnificationXref
id: PW392338
db: PathWhiz

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Sodium
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Sodium

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 1169
type: UnificationXref
id: 1169
db: PubChem-compound

Reference/CAS 58337-43-2
type: UnificationXref
id: 58337-43-2
db: CAS

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/KEGG Compound C03483
type: UnificationXref
id: C03483
db: KEGG Compound

Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/ChemSpider 21814
type: UnificationXref
id: 21814
db: ChemSpider

Reference/HMDB HMDB0003339
type: UnificationXref
id: HMDB0003339
db: HMDB

SubPathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway383667
pathway component: SubPathwayInteraction383667

ChemicalStructure/PW C007296
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 16741146
type: UnificationXref
id: 16741146
db: PubChem-compound

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Reference/ChEBI CHEBI 17882
type: UnificationXref
id: CHEBI:17882
db: ChEBI

Reference/SMPDB SMP0000905
type: UnificationXref
id: SMP0000905
db: SMPDB

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

UDP-N-acetylmuramoyl-L-alanine
type: SmallMolecule
cellular location: Cytosol
entity reference: UDP-N-acetylmuramoyl-L-alanine

Reference/SMPDB SMP0384071
type: UnificationXref
id: SMP0384071
db: SMPDB

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Reference/HMDB HMDB0041827
type: UnificationXref
id: HMDB0041827
db: HMDB

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C040829/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Hydrogen Ion

L-Glutamic acid
type: SmallMolecule
cellular location: Inner Membrane
entity reference: L-Glutamic acid

ChemicalStructure/PW C001849
type: ChemicalStructure
structure format: SMILES
structure data: N[C@H](CCC(O)=O)C(O)=O

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Adenosine diphosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Adenosine diphosphate

ChemicalStructure/PW C001052
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-607
type: UnificationXref
id: CPD-607
db: BioCyc

Compound/PW C001104 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0