Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Compound/PW C001415/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic γ-semialdehyde
stoichiometric coefficient: 1.0

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

ChemicalStructure/PW C001415
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC=O)C(O)=O

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

NADH
type: SmallMolecule
entity reference: NADH

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

1-Pyrroline-5-carboxylic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 1159
xref: Reference/HMDB HMDB0001301
xref: Reference/ChEBI CHEBI 1372
xref: Reference/CAS 2906-39-0
xref: Reference/BioCyc l-delta(1)-pyrroline 5-carboxylate
xref: Reference/KEGG Compound C04322
xref: Reference/PubChem-compound 1196
chemical formula: C5H7NO2
molecular weight: 113.047676
structure: ChemicalStructure/PW C001003

Reference/CAS 13254-53-0
type: UnificationXref
id: 13254-53-0
db: CAS

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Escherichia coli O157:H7 str. EC4115
type: BioSource
xref: Reference/TAXONOMY 444450

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16389
type: UnificationXref
id: CHEBI:16389
db: ChEBI

Protein/28266/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

ReactionCoupledTransport6561
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Inner Membrane/Stoichiometry/1.0
right: Phosphate
right: L-Glutamic acid
right: Adenosine diphosphate
right: Hydrogen Ion
spontaneous: false
left: Water
left: Adenosine triphosphate
left: L-Glutamic acid
name: Adenosine triphosphate + L-Glutamic acid + Water → Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 167893
type: UnificationXref
id: 167893
db: ChemSpider

L-Glutamic acid 5-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17798
xref: Reference/ChemSpider 167893
xref: Reference/BioCyc L-GLUTAMATE-5-P
xref: Reference/HMDB HMDB0001228
xref: Reference/CAS 13254-53-0
xref: Reference/PubChem-compound 193475
xref: Reference/KEGG Compound C03287
chemical formula: C5H10NO7P
molecular weight: 227.01949
structure: ChemicalStructure/PW C000951

NAD
type: SmallMolecule
entity reference: NAD

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Compound/PW C001034 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17232
type: UnificationXref
id: CHEBI:17232
db: ChEBI

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc PRO
type: UnificationXref
id: PRO
db: BioCyc

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

γ-glutamyl kinase
type: Complex
component stoichiometry: Protein/28266/Stoichiometry/4.0
component: Unknown

Reference/ChEBI CHEBI 17203
type: UnificationXref
id: CHEBI:17203
db: ChEBI

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 167744
type: UnificationXref
id: 167744
db: ChemSpider

L-Glutamic acid 5-phosphate
type: SmallMolecule
entity reference: L-Glutamic acid 5-phosphate

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C03287
type: UnificationXref
id: C03287
db: KEGG Compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

1-Pyrroline-5-carboxylic acid
type: SmallMolecule
entity reference: 1-Pyrroline-5-carboxylic acid

proline dehydrogenase
type: Complex
component stoichiometry: Protein/28266/Stoichiometry/2.0
component: Unknown

pyrroline-5-carboxylate reductase
type: Complex
component stoichiometry: Protein/28266/Stoichiometry/10.0
component: Unknown

glutamate-5-semialdehyde dehydrogenase
type: Complex
component stoichiometry: Protein/28266/Stoichiometry/4.0
component: Unknown

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Ubiquinone-1
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16389
xref: Reference/ChemSpider 4307
xref: Reference/PubChem-compound 4462
xref: Reference/CAS 727-81-1
xref: Reference/HMDB HMDB0002012
xref: Reference/KEGG Compound C00399
chemical formula: C14H18O4
molecular weight: 250.12051
structure: ChemicalStructure/PW C001347

Ubiquinol-1
type: SmallMolecule
entity reference: Ubiquinol-1

NADPH
type: SmallMolecule
entity reference: NADPH

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/GENE ONTOLOGY GO 0070258
type: UnificationXref
id: GO:0070258
db: GENE ONTOLOGY

NADP
type: SmallMolecule
entity reference: NADP

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Unknown
type: Protein
entity reference: Unknown

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/BioCyc L-GLUTAMATE-5-P
type: UnificationXref
id: L-GLUTAMATE-5-P
db: BioCyc

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Endocytosis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway389253
pathway component: SubPathwayInteraction389253
name: SubPathway

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/PubChem-compound 193305
type: UnificationXref
id: 193305
db: PubChem-compound

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid
name: SubPathwayOutput

Reference/HMDB HMDB0001301
type: UnificationXref
id: HMDB0001301
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/BioCyc l-delta(1)-pyrroline 5-carboxylate
type: UnificationXref
id: l-delta(1)-pyrroline_5-carboxylate
db: BioCyc

Hydrogen Ion
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Hydrogen Ion

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/ChemSpider 1159
type: UnificationXref
id: 1159
db: ChemSpider

Reference/ChemSpider 4307
type: UnificationXref
id: 4307
db: ChemSpider

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

ChemicalStructure/PW C001347
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(OC)C(=O)C(CC=C(C)C)=C(C)C1=O

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070258

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ReactionCoupledTransportCatalysis6623
type: Catalysis
controller: Unknown
controlled: ReactionCoupledTransport6561
control type: ACTIVATION

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/CAS 496-92-4
type: UnificationXref
id: 496-92-4
db: CAS

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Compound/PW C000106/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Proline
stoichiometric coefficient: 1.0

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/PubChem-compound 447920
type: UnificationXref
id: 447920
db: PubChem-compound

ChemicalStructure/PW C000106
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)[C@@H]1CCCN1

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reaction2721
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001415/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001003/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: L-Glutamic γ-semialdehyde
spontaneous: true
left: Water
left: 1-Pyrroline-5-carboxylic acid
left: Hydrogen Ion
name: 1-Pyrroline-5-carboxylic acid + Hydrogen Ion + Water → L-Glutamic γ-semialdehyde
conversion direction: LEFT_TO_RIGHT

Compound/PW C000095 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/PathWhiz PW396211
type: UnificationXref
id: PW396211
db: PathWhiz

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reaction2717
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001415/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001003/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Water
right: 1-Pyrroline-5-carboxylic acid
right: Hydrogen Ion
spontaneous: false
left: L-Glutamic γ-semialdehyde
name: L-Glutamic γ-semialdehyde → 1-Pyrroline-5-carboxylic acid + Hydrogen Ion + Water
conversion direction: LEFT_TO_RIGHT

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00148
type: UnificationXref
id: C00148
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/TAXONOMY 444450
type: UnificationXref
id: 444450
db: TAXONOMY

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/CAS 147-85-3
type: UnificationXref
id: 147-85-3
db: CAS

Compound/PW C000951/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid 5-phosphate
stoichiometric coefficient: 1.0

Compound/PW C042948/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquinol-1
stoichiometric coefficient: 1.0

SubPathwayInteraction389253
type: Interaction
name: SubPathwayReaction
name: SubPathway389253Reaction
participant: L-Glutamic acid

Reference/SMPDB SMP0387411
type: UnificationXref
id: SMP0387411
db: SMPDB

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Adenosine triphosphate

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00399
type: UnificationXref
id: C00399
db: KEGG Compound

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Water
type: SmallMolecule
entity reference: Water

Reference/HMDB HMDB0001228
type: UnificationXref
id: HMDB0001228
db: HMDB

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Phosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Phosphate

L-Glutamic γ-semialdehyde
type: SmallMolecule
entity reference: L-Glutamic γ-semialdehyde

Reference/ChemSpider 128566
type: UnificationXref
id: 128566
db: ChemSpider

Unknown
type: Protein
cellular location: Inner Membrane
entity reference: Unknown

Compound/PW C000414 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1372
type: UnificationXref
id: CHEBI:1372
db: ChEBI

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

1.5.5.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001347/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001003/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000106/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042948/Stoichiometry/1.0
right: 1-Pyrroline-5-carboxylic acid
right: Hydrogen Ion
right: Ubiquinol-1
spontaneous: false
EC number: 1.5.5.2
left: Ubiquinone-1
left: L-Proline
name: L-Proline + Ubiquinone-1 → 1-Pyrroline-5-carboxylic acid + Hydrogen Ion + Ubiquinol-1
conversion direction: LEFT_TO_RIGHT

Water
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Water

1.5.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001003/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000106/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADP
right: L-Proline
spontaneous: false
EC number: 1.5.1.2
left: 1-Pyrroline-5-carboxylic acid
left: Hydrogen Ion
left: NADPH
name: 1-Pyrroline-5-carboxylic acid + Hydrogen Ion + NADPH → L-Proline + NADP
conversion direction: LEFT_TO_RIGHT

Reaction636195
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000951/Stoichiometry/1.0
right: Adenosine diphosphate
right: L-Glutamic acid 5-phosphate
spontaneous: false
left: L-Glutamic acid
left: Adenosine triphosphate
name: Adenosine triphosphate + L-Glutamic acid → Adenosine diphosphate + L-Glutamic acid 5-phosphate
conversion direction: LEFT_TO_RIGHT

Reaction636194
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001415/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: NADH
right: L-Glutamic acid
right: Hydrogen Ion
spontaneous: false
left: Water
left: L-Glutamic γ-semialdehyde
left: NAD
name: L-Glutamic γ-semialdehyde + NAD + Water → 2 Hydrogen Ion + L-Glutamic acid + NADH
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

1.2.1.41
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001415/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000951/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: NADP
right: L-Glutamic γ-semialdehyde
right: Phosphate
spontaneous: false
EC number: 1.2.1.41
left: Hydrogen Ion
left: L-Glutamic acid 5-phosphate
left: NADPH
name: Hydrogen Ion + L-Glutamic acid 5-phosphate + NADPH → L-Glutamic γ-semialdehyde + NADP + Phosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C042948
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C(C)=C(CC=C(C)C)C(O)=C1OC

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

ChemicalStructure/PW C001003
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1CCC=N1

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Unknown
type: ProteinReference

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

ChemicalStructure/PW C000951
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(=O)OP(O)(O)=O)C(O)=O

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/HMDB HMDB0002104
type: UnificationXref
id: HMDB0002104
db: HMDB

Reference/HMDB HMDB0000162
type: UnificationXref
id: HMDB0000162
db: HMDB

ReactionCatalysis630656
type: Catalysis
controller: glutamate-5-semialdehyde dehydrogenase
controlled: 1.2.1.41
control type: ACTIVATION

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C001347/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquinone-1
stoichiometric coefficient: 1.0

ReactionCatalysis630658
type: Catalysis
controller: proline dehydrogenase
controlled: 1.5.5.2
control type: ACTIVATION

ReactionCatalysis630657
type: Catalysis
controller: pyrroline-5-carboxylate reductase
controlled: 1.5.1.2
control type: ACTIVATION

L-Proline
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17203
xref: Reference/ChemSpider 128566
xref: Reference/BioCyc PRO
xref: Reference/CAS 147-85-3
xref: Reference/KEGG Compound C00148
xref: Reference/HMDB HMDB0000162
xref: Reference/PubChem-compound 145742
chemical formula: C5H9NO2
molecular weight: 115.06333
structure: ChemicalStructure/PW C000106

ReactionCatalysis630659
type: Catalysis
controller: proline dehydrogenase
controlled: Reaction636194
control type: ACTIVATION

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Compound/PW C001003/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-Pyrroline-5-carboxylic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01165
type: UnificationXref
id: C01165
db: KEGG Compound

Ubiquinol-1
type: SmallMoleculeReference
xref: Reference/PubChem-compound 447920
chemical formula: C14H20O4
molecular weight: 252.13615
structure: ChemicalStructure/PW C042948

Phosphate
type: SmallMolecule
entity reference: Phosphate

Reference/PubChem-compound 145742
type: UnificationXref
id: 145742
db: PubChem-compound

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Ubiquinone-1
type: SmallMolecule
entity reference: Ubiquinone-1

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/ChEBI CHEBI 17798
type: UnificationXref
id: CHEBI:17798
db: ChEBI

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Protein/28266/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Protein/28266/Stoichiometry/10.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 10.0

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

ReactionCatalysis630660
type: Catalysis
controller: γ-glutamyl kinase
controlled: Reaction636195
control type: ACTIVATION

Reference/KEGG Compound C04322
type: UnificationXref
id: C04322
db: KEGG Compound

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/BioCyc L-GLUTAMATE GAMMA-SEMIALDEHYDE
type: UnificationXref
id: L-GLUTAMATE_GAMMA-SEMIALDEHYDE
db: BioCyc

Proline Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/5612926
pathway order: PathwayEnzymeReaction/5612928
pathway order: PathwayEnzymeReaction/5612927
pathway order: PathwayEnzymeReaction/5612933
pathway order: PathwayEnzymeReaction/5612932
pathway order: PathwaySubPathway/389253
pathway order: PathwayEnzymeReaction/5612931
pathway order: PathwayEnzymeReaction/5612930
pathway order: PathwayEnzymeReaction/5612929
pathway component: ReactionCatalysis630656
pathway component: 1.5.5.2
pathway component: 1.5.1.2
pathway component: ReactionCatalysis630658
pathway component: Reaction636195
pathway component: ReactionCoupledTransport6561
pathway component: ReactionCatalysis630657
pathway component: Reaction636194
pathway component: Reaction2717
pathway component: ReactionCatalysis630659
pathway component: ReactionCatalysis630660
pathway component: Endocytosis
pathway component: 1.2.1.41
pathway component: ReactionCoupledTransportCatalysis6623
pathway component: Reaction2721
xref: Reference/PathWhiz PW396211
xref: Reference/SMPDB SMP0387411
organism: Escherichia coli O157:H7 str. EC4115

Reference/PubChem-compound 4462
type: UnificationXref
id: 4462
db: PubChem-compound

L-Glutamic γ-semialdehyde
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002104
xref: Reference/PubChem-compound 193305
xref: Reference/CAS 496-92-4
xref: Reference/ChemSpider 167744
xref: Reference/KEGG Compound C01165
xref: Reference/BioCyc L-GLUTAMATE GAMMA-SEMIALDEHYDE
xref: Reference/ChEBI CHEBI 17232
chemical formula: C5H9NO3
molecular weight: 131.05824
structure: ChemicalStructure/PW C001415

Reference/PubChem-compound 1196
type: UnificationXref
id: 1196
db: PubChem-compound

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/CAS 727-81-1
type: UnificationXref
id: 727-81-1
db: CAS

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/HMDB HMDB0002012
type: UnificationXref
id: HMDB0002012
db: HMDB

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Compound/PW C040034/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

L-Glutamic acid
type: SmallMolecule
cellular location: Inner Membrane
entity reference: L-Glutamic acid

Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

L-Proline
type: SmallMolecule
entity reference: L-Proline

Reference/CAS 2906-39-0
type: UnificationXref
id: 2906-39-0
db: CAS

Adenosine diphosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Adenosine diphosphate

Reference/PubChem-compound 193475
type: UnificationXref
id: 193475
db: PubChem-compound

Compound/PW C001104 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0