PathWhiz

Pathway Description

Glycine Biosynthesis

Escherichia coli (strain MS 21-1)

Metabolic Pathway

Glycine biosynthesis is dependent on L-serine. L-serine is enters the cell through transporters (serine / threonine:H+ symporter TdcC, serine/threonine: Na symporter , serine:H+ symporter SdaC) and then proceeds through reversible reaction with a tetrahydrofolic acid through a serine hydroxymethyltransferase enzyme in order to produce glycine, 5,10-methylene tetrahydrofolate and water. 5,10-methylene tetrahydrofolate is a major source of one-carbon units used in other metabolic pathways.

References

Glycine Biosynthesis References

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from PW000808

Highlighted elements will appear in red.

Highlight Compounds

	5,10-Methylene-THF
	Glycine
	Hydrogen Ion
	L-Serine
	Sodium
	Tetrahydrofolic acid
	Water

Highlight Proteins

D-galactonate dehydratase family member RspA

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