D-Glucaric acid
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: D-Glucaric acid

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/CAS 2553-59-5
type: UnificationXref
id: 2553-59-5
db: CAS

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

2-Dehydro-3-deoxy-D-glucarate
type: SmallMolecule
entity reference: 2-Dehydro-3-deoxy-D-glucarate

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

NADH
type: SmallMolecule
entity reference: NADH

Reference/ChemSpider 58
type: UnificationXref
id: 58
db: ChemSpider

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Compound/PW C000498 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Galactaric acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Acetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-CoA
name: SubPathwayInput

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/CAS 473-81-4
type: UnificationXref
id: 473-81-4
db: CAS

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

NAD
type: SmallMolecule
entity reference: NAD

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 1005
type: UnificationXref
id: 1005
db: PubChem-compound

5-dehydro-4-deoxy-D-glucarate(2−)
type: SmallMolecule
entity reference: 5-dehydro-4-deoxy-D-glucarate(2−)

Reference/PubChem-compound 1122
type: UnificationXref
id: 1122
db: PubChem-compound

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Compound/PW C000180/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvic acid
stoichiometric coefficient: 1.0

Pyruvic acid
type: SmallMolecule
entity reference: Pyruvic acid

Unknown
type: ProteinReference

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

ChemicalStructure/PW C011104
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Reference/PubChem-compound 59
type: UnificationXref
id: 59
db: PubChem-compound

ReactionCatalysis675268
type: Catalysis
controller: Unknown
controlled: 4.2.1.42
control type: ACTIVATION

ReactionCatalysis675269
type: Catalysis
controller: Unknown
controlled: 4.1.2.20
control type: ACTIVATION

Reference/ChemSpider 388334
type: UnificationXref
id: 388334
db: ChemSpider

Compound/PW C000090/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyceric acid
stoichiometric coefficient: 1.0

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

5-dehydro-4-deoxy-D-glucarate(2−)
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 42819
chemical formula: C6H6O7
molecular weight: 190.01135
structure: ChemicalStructure/PW C040865

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

TransportCatalysis33771
type: Catalysis
controller: Unknown
controlled: Transport52517
control type: ACTIVATION

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/PubChem-compound 440165
type: UnificationXref
id: 440165
db: PubChem-compound

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

Galactaric acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30852
xref: Reference/KEGG Compound C00879
xref: Reference/ChemSpider 2301286
xref: Reference/HMDB HMDB0000639
xref: Reference/CAS 526-99-8
xref: Reference/PubChem-compound 3037582
chemical formula: C6H10O8
molecular weight: 210.03757
structure: ChemicalStructure/PW C000498

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

2-Dehydro-3-deoxy-D-glucarate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440165
xref: Reference/ChEBI CHEBI 17305
chemical formula: C6H8O7
molecular weight: 192.02701
structure: ChemicalStructure/PW C041167

ReactionCatalysis675279
type: Catalysis
controller: enolase
controlled: Reaction679020
control type: ACTIVATION

ReactionCatalysis675275
type: Catalysis
controller: Unknown
controlled: Reaction679016
control type: ACTIVATION

ReactionCatalysis675277
type: Catalysis
controller: Unknown
controlled: 4.2.1.40
control type: ACTIVATION

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/ChEBI CHEBI 32398
type: UnificationXref
id: CHEBI:32398
db: ChEBI

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

NADPH
type: SmallMolecule
entity reference: NADPH

Compound/PW C000498/Stoichiometry/1.0
type: Stoichiometry
physical entity: Galactaric acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Compound/PW C011104 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucaric acid
stoichiometric coefficient: 1.0

2-Phosphoglyceric acid
type: SmallMolecule
entity reference: 2-Phosphoglyceric acid

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

TransportCatalysis33770
type: Catalysis
controller: Unknown
controlled: Transport52516
control type: ACTIVATION

NADP
type: SmallMolecule
entity reference: NADP

ReactionCatalysis675270
type: Catalysis
controller: Unknown
controlled: Reaction679011
control type: ACTIVATION

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reference/HMDB HMDB0029881
type: UnificationXref
id: HMDB0029881
db: HMDB

ReactionCatalysis675271
type: Catalysis
controller: Unknown
controlled: 2.7.1.165
control type: ACTIVATION

ReactionCatalysis675272
type: Catalysis
controller: Pyruvate dehydrogenase complex
controlled: 1.2.4.1
control type: ACTIVATION

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

2-Phosphoglyceric acid
type: SmallMoleculeReference
xref: Reference/CAS 2553-59-5
xref: Reference/ChemSpider 58
xref: Reference/BioCyc 2-PG
xref: Reference/ChEBI CHEBI 24344
xref: Reference/PubChem-compound 59
xref: Reference/HMDB HMDB0000362
chemical formula: C3H7O7P
molecular weight: 185.99294
structure: ChemicalStructure/PW C000262

Compound/PW C003011/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tartronate semialdehyde
stoichiometric coefficient: 1.0

Reference/CAS 138-08-9
type: UnificationXref
id: 138-08-9
db: CAS

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/PathWhiz PW402511
type: UnificationXref
id: PW402511
db: PathWhiz

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

ChemicalStructure/PW C000498
type: ChemicalStructure
structure format: SMILES

Reference/TAXONOMY 199310
type: UnificationXref
id: 199310
db: TAXONOMY

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/PathWhiz PW000779
type: UnificationXref
id: PW000779
db: PathWhiz

Glyceric acid
type: SmallMolecule
entity reference: Glyceric acid

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/PubChem-compound 439194
type: UnificationXref
id: 439194
db: PubChem-compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000262
type: ChemicalStructure
structure format: SMILES
structure data: OCC(OP(O)(O)=O)C(O)=O

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Protein/27320/Stoichiometry/60.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 60.0

D-Glucaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucaric acid

Reference/CAS 526-99-8
type: UnificationXref
id: 526-99-8
db: CAS

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/SMPDB SMP0392783
type: UnificationXref
id: SMP0392783
db: SMPDB

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

TCA Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway397086
pathway component: SubPathwayInteraction397086
xref: Reference/SMPDB SMP0000802
xref: Reference/PathWhiz PW000779
name: SubPathway

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/KEGG Compound C00258
type: UnificationXref
id: C00258
db: KEGG Compound

Compound/PW C000498 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Galactaric acid
stoichiometric coefficient: 1.0

enolase
type: Complex
component stoichiometry: Protein/27320/Stoichiometry/2.0
component: Unknown

pyruvate kinase
type: Complex
component stoichiometry: Protein/27320/Stoichiometry/4.0
component: Unknown

phosphoenolpyruvate synthetase
type: Complex
component stoichiometry: Protein/27320/Stoichiometry/2.0
component: Unknown

Compound/PW C011104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucaric acid
stoichiometric coefficient: 1.0

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Pyruvate dehydrogenase complex
type: Complex
component stoichiometry: Protein/27320/Stoichiometry/60.0
component: Unknown

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/GENE ONTOLOGY GO 0005620
type: UnificationXref
id: GO:0005620
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 24344
type: UnificationXref
id: CHEBI:24344
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/PubChem-compound 3037582
type: UnificationXref
id: 3037582
db: PubChem-compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Reference/ChemSpider 587
type: UnificationXref
id: 587
db: ChemSpider

Phosphoenolpyruvic acid
type: SmallMoleculeReference
xref: Reference/CAS 138-08-9
xref: Reference/ChEBI CHEBI 44897
xref: Reference/KEGG Compound C00074
xref: Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
xref: Reference/ChemSpider 980
xref: Reference/PubChem-compound 1005
xref: Reference/HMDB HMDB0000263
chemical formula: C3H5O6P
molecular weight: 167.98238
structure: ChemicalStructure/PW C000180

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/ChemSpider 2301286
type: UnificationXref
id: 2301286
db: ChemSpider

Compound/PW C011104/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucaric acid
stoichiometric coefficient: 1.0

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Phosphoenolpyruvic acid
type: SmallMolecule
entity reference: Phosphoenolpyruvic acid

Reference/HMDB HMDB0000362
type: UnificationXref
id: HMDB0000362
db: HMDB

Reference/SMPDB SMP0000802
type: UnificationXref
id: SMP0000802
db: SMPDB

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040865
type: ChemicalStructure
structure format: SMILES
structure data: O[C@@H](CC(=O)C([O-])=O)[C@@H](O)C([O-])=O

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

2.7.1.40
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Pyruvic acid
right: Adenosine triphosphate
spontaneous: false
EC number: 2.7.1.40
left: Adenosine diphosphate
left: Hydrogen Ion
left: Phosphoenolpyruvic acid
name: Adenosine diphosphate + Hydrogen Ion + Phosphoenolpyruvic acid → Adenosine triphosphate + Pyruvic acid
conversion direction: LEFT_TO_RIGHT

Reaction679020
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000262/Stoichiometry/1.0
right: Water
right: Phosphoenolpyruvic acid
spontaneous: false
left: 2-Phosphoglyceric acid
name: 2-Phosphoglyceric acid ↔ Phosphoenolpyruvic acid + Water
conversion direction: REVERSIBLE

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Water
type: SmallMolecule
entity reference: Water

1.2.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
right: NADH
right: Carbon dioxide
right: Acetyl-CoA
spontaneous: false
EC number: 1.2.4.1
left: Coenzyme A
left: Pyruvic acid
left: NAD
name: Coenzyme A + NAD + Pyruvic acid → Acetyl-CoA + Carbon dioxide + NADH
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

2.7.1.165
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000090/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000262/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: 2-Phosphoglyceric acid
right: Adenosine diphosphate
right: Hydrogen Ion
spontaneous: false
EC number: 2.7.1.165
left: Glyceric acid
left: Adenosine triphosphate
name: Adenosine triphosphate + Glyceric acid → 2-Phosphoglyceric acid + Adenosine diphosphate + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

4.2.1.40
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040865/Stoichiometry/1.0
participant stoichiometry: Compound/PW C011104/Stoichiometry/1.0
right: Water
right: 5-dehydro-4-deoxy-D-glucarate(2−)
spontaneous: false
EC number: 4.2.1.40
left: D-Glucaric acid
name: D-Glucaric acid → 5-dehydro-4-deoxy-D-glucarate(2−) + Water
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 1090
type: UnificationXref
id: 1090
db: ChemSpider

Reference/HMDB HMDB0000139
type: UnificationXref
id: HMDB0000139
db: HMDB

Reaction679016
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041167/Stoichiometry/1.0
participant stoichiometry: Compound/PW C011104/Stoichiometry/1.0
right: Water
right: 2-Dehydro-3-deoxy-D-glucarate
spontaneous: false
left: D-Glucaric acid
name: D-Glucaric acid → 2-Dehydro-3-deoxy-D-glucarate + Water
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

ChemicalStructure/PW C041167
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reaction679011
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000090/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003011/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADP
right: Glyceric acid
spontaneous: false
left: Tartronate semialdehyde
left: Hydrogen Ion
left: NADPH
name: Hydrogen Ion + NADPH + Tartronate semialdehyde → Glyceric acid + NADP
conversion direction: LEFT_TO_RIGHT

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

4.1.2.20
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040865/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003011/Stoichiometry/1.0
right: Tartronate semialdehyde
right: Pyruvic acid
spontaneous: false
EC number: 4.1.2.20
left: 5-dehydro-4-deoxy-D-glucarate(2−)
name: 5-dehydro-4-deoxy-D-glucarate(2−) → Pyruvic acid + Tartronate semialdehyde
conversion direction: LEFT_TO_RIGHT

Transport52517
type: Transport
participant stoichiometry: Compound/PW C000498 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000498 Cytosol/Stoichiometry/1.0
right: Galactaric acid
spontaneous: false
left: Galactaric acid
name: Galactaric acid (→) Transport: Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC), Periplasmic Space to Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC), Cytosol
conversion direction: LEFT_TO_RIGHT

Transport52516
type: Transport
participant stoichiometry: Compound/PW C011104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C011104 Periplasmic Space/Stoichiometry/1.0
right: D-Glucaric acid
spontaneous: false
left: D-Glucaric acid
name: D-Glucaric acid (→) Transport: Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC), Periplasmic Space to Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC), Cytosol
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
type: UnificationXref
id: PHOSPHO-ENOL-PYRUVATE
db: BioCyc

Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
type: BioSource
xref: Reference/TAXONOMY 199310

4.2.1.42
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040865/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000498/Stoichiometry/1.0
right: Water
right: 5-dehydro-4-deoxy-D-glucarate(2−)
spontaneous: false
EC number: 4.2.1.42
left: Galactaric acid
name: Galactaric acid → 5-dehydro-4-deoxy-D-glucarate(2−) + Water
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000263
type: UnificationXref
id: HMDB0000263
db: HMDB

ChemicalStructure/PW C000180
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=C)OP(O)(O)=O

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C000164/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Protein/27320/Stoichiometry/4.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 16992
type: UnificationXref
id: CHEBI:16992
db: ChEBI

Reference/KEGG Compound C01146
type: UnificationXref
id: C01146
db: KEGG Compound

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/HMDB HMDB0006938
type: UnificationXref
id: HMDB0006938
db: HMDB

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Glyceric acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 388334
xref: Reference/HMDB HMDB0000139
xref: Reference/PubChem-compound 439194
xref: Reference/ChEBI CHEBI 32398
xref: Reference/KEGG Compound C00258
xref: Reference/BioCyc 2-PG
xref: Reference/CAS 473-81-4
chemical formula: C3H6O4
molecular weight: 106.02661
structure: ChemicalStructure/PW C000090

Galactaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Galactaric acid

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/CAS 87-73-0
type: UnificationXref
id: 87-73-0
db: CAS

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Tartronate semialdehyde
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0006938
xref: Reference/ChemSpider 1090
xref: Reference/CAS 2480-77-5
xref: Reference/ChEBI CHEBI 16992
xref: Reference/KEGG Compound C01146
xref: Reference/PubChem-compound 1122
chemical formula: C3H4O4
molecular weight: 104.010956
structure: ChemicalStructure/PW C003011

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reaction679024
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: Hydrogen Ion
right: Adenosine monophosphate
right: Phosphate
right: Phosphoenolpyruvic acid
spontaneous: false
left: Water
left: Pyruvic acid
left: Adenosine triphosphate
name: Adenosine triphosphate + Pyruvic acid + Water → Adenosine monophosphate + 2 Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00074
type: UnificationXref
id: C00074
db: KEGG Compound

Tartronate semialdehyde
type: SmallMolecule
entity reference: Tartronate semialdehyde

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChEBI CHEBI 17305
type: UnificationXref
id: CHEBI:17305
db: ChEBI

Reference/KEGG Compound C00879
type: UnificationXref
id: C00879
db: KEGG Compound

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Galactaric acid
type: SmallMolecule
entity reference: Galactaric acid

Reference/CAS 2480-77-5
type: UnificationXref
id: 2480-77-5
db: CAS

Compound/PW C000262/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Phosphoglyceric acid
stoichiometric coefficient: 1.0

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Phosphate
type: SmallMolecule
entity reference: Phosphate

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Periplasmic Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005620

SubPathwayInteraction397086
type: Interaction
name: SubPathway397086Reaction
name: SubPathwayReaction
participant: Acetyl-CoA

Compound/PW C040865/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-dehydro-4-deoxy-D-glucarate(2−)
stoichiometric coefficient: 1.0

Reference/PubChem-compound 607
type: UnificationXref
id: 607
db: PubChem-compound

ReactionCatalysis675281
type: Catalysis
controller: pyruvate kinase
controlled: 2.7.1.40
control type: ACTIVATION

ChemicalStructure/PW C000090
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@@H](O)C(O)=O

Compound/PW C041167/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Dehydro-3-deoxy-D-glucarate
stoichiometric coefficient: 1.0

ReactionCatalysis675283
type: Catalysis
controller: phosphoenolpyruvate synthetase
controlled: Reaction679024
control type: ACTIVATION

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Reference/ChEBI CHEBI 1139229
type: UnificationXref
id: CHEBI:1139229
db: ChEBI

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/KEGG Compound C00767
type: UnificationXref
id: C00767
db: KEGG Compound

Unknown
type: Protein
entity reference: Unknown

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 44897
type: UnificationXref
id: CHEBI:44897
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C003011
type: ChemicalStructure
structure format: SMILES
structure data: OC(C=O)C(O)=O

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Galactaric acid
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Galactaric acid

D-Glucarate and D-Galactarate Degradation
type: Pathway
pathway order: PathwayEnzymeReaction/5708877
pathway order: PathwaySubPathway/397086
pathway order: PathwayEnzymeReaction/5708878
pathway order: PathwayTransport/5708899
pathway order: PathwayTransport/5708901
pathway order: PathwayEnzymeReaction/5708875
pathway order: PathwayEnzymeReaction/5708876
pathway order: PathwayEnzymeReaction/5708898
pathway order: PathwayEnzymeReaction/5708874
pathway order: PathwayEnzymeReaction/5708896
pathway order: PathwayEnzymeReaction/5708882
pathway order: PathwayEnzymeReaction/5708894
pathway order: PathwayEnzymeReaction/5708892
pathway component: ReactionCatalysis675268
pathway component: ReactionCatalysis675269
pathway component: TCA Cycle
pathway component: 2.7.1.40
pathway component: TransportCatalysis33771
pathway component: Reaction679020
pathway component: 1.2.4.1
pathway component: 2.7.1.165
pathway component: 4.2.1.40
pathway component: Reaction679016
pathway component: ReactionCatalysis675281
pathway component: ReactionCatalysis675283
pathway component: ReactionCatalysis675279
pathway component: ReactionCatalysis675275
pathway component: ReactionCatalysis675277
pathway component: Reaction679011
pathway component: 4.1.2.20
pathway component: Transport52517
pathway component: Transport52516
pathway component: Reaction679024
pathway component: TransportCatalysis33770
pathway component: ReactionCatalysis675270
pathway component: ReactionCatalysis675271
pathway component: ReactionCatalysis675272
pathway component: 4.2.1.42
xref: Reference/SMPDB SMP0392783
xref: Reference/PathWhiz PW402511
organism: Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Reference/BioCyc 2-PG
type: UnificationXref
id: 2-PG
db: BioCyc

Protein/27320/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 30852
type: UnificationXref
id: CHEBI:30852
db: ChEBI

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Compound/PW C040034/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/HMDB HMDB0000639
type: UnificationXref
id: HMDB0000639
db: HMDB

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/ChEBI CHEBI 42819
type: UnificationXref
id: CHEBI:42819
db: ChEBI

Reference/ChemSpider 980
type: UnificationXref
id: 980
db: ChemSpider

D-Glucaric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00767
xref: Reference/ChemSpider 587
xref: Reference/HMDB HMDB0029881
xref: Reference/PubChem-compound 607
xref: Reference/CAS 87-73-0
xref: Reference/ChEBI CHEBI 1139229
chemical formula: C6H10O8
molecular weight: 210.03757
structure: ChemicalStructure/PW C011104

D-Glucaric acid
type: SmallMolecule
entity reference: D-Glucaric acid

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS