Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/CAS 2553-59-5
type: UnificationXref
id: 2553-59-5
db: CAS

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChEBI CHEBI 30797
type: UnificationXref
id: CHEBI:30797
db: ChEBI

Protein/29184/Stoichiometry/10.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 10.0

Reference/TAXONOMY 1244083
type: UnificationXref
id: 1244083
db: TAXONOMY

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/ChemSpider 58
type: UnificationXref
id: 58
db: ChemSpider

triosephosphate isomerase
type: Complex
component stoichiometry: Protein/29184 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Fructose 1,6-bisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001058
xref: Reference/BioCyc FRUCTOSE-16-DIPHOSPHATE
xref: Reference/CAS 488-69-7
xref: Reference/ChEBI CHEBI 16905
xref: Reference/ChemSpider 393165
xref: Reference/KEGG Compound C00354
xref: Reference/PubChem-compound 445557
chemical formula: C6H14O12P2
molecular weight: 339.99606
structure: ChemicalStructure/PW C000833

NAD
type: SmallMolecule
entity reference: NAD

Compound/PW C000101/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Malic acid
stoichiometric coefficient: 1.0

Reference/BioCyc OXALACETIC ACID
type: UnificationXref
id: OXALACETIC_ACID
db: BioCyc

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Galactose Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway407480
pathway component: SubPathwayInteraction407480
xref: Reference/SMPDB SMP0000841
xref: Reference/PathWhiz PW000821
name: SubPathway

Reference/HMDB HMDB0003498
type: UnificationXref
id: HMDB0003498
db: HMDB

Unknown
type: ProteinReference

Reference/UniProt M5IS85
type: UnificationXref
id: M5IS85
db: UniProt

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Fructose 1,6-bisphosphate
type: SmallMolecule
entity reference: Fructose 1,6-bisphosphate

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/CAS 97-67-6
type: UnificationXref
id: 97-67-6
db: CAS

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

β-D-Glucose 6-phosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 388538
xref: Reference/KEGG Compound C01172
xref: Reference/ChEBI CHEBI 17719
xref: Reference/HMDB HMDB0003498
xref: Reference/PubChem-compound 439427
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C001906

Reference/ChemSpider 709
type: UnificationXref
id: 709
db: ChemSpider

Reference/ChemSpider 704
type: UnificationXref
id: 704
db: ChemSpider

Reference/ChemSpider 945
type: UnificationXref
id: 945
db: ChemSpider

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/CAS 488-69-7
type: UnificationXref
id: 488-69-7
db: CAS

Reference/CAS 138-08-9
type: UnificationXref
id: 138-08-9
db: CAS

D-Glyceraldehyde 3-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc GAP
xref: Reference/ChEBI CHEBI 17138
xref: Reference/HMDB HMDB0001112
xref: Reference/ChemSpider 709
xref: Reference/KEGG Compound C00661
xref: Reference/PubChem-compound 729
xref: Reference/CAS 591-59-3
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C000869

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/SMPDB SMP0000841
type: UnificationXref
id: SMP0000841
db: SMPDB

Glyceric acid 1,3-biphosphate
type: SmallMoleculeReference
xref: Reference/CAS 1981-49-3
xref: Reference/ChemSpider 663
xref: Reference/BioCyc DPG
xref: Reference/HMDB HMDB0001270
xref: Reference/KEGG Compound C00236
xref: Reference/PubChem-compound 683
chemical formula: C3H8O10P2
molecular weight: 265.95926
structure: ChemicalStructure/PW C000983

Reference/KEGG Compound C00111
type: UnificationXref
id: C00111
db: KEGG Compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00236
type: UnificationXref
id: C00236
db: KEGG Compound

Glyceraldehyde-3-phosphate dehydrogenase
type: Protein
entity reference: Glyceraldehyde-3-phosphate dehydrogenase

Fructose-1,6-bisphosphatase class 1
type: Protein
entity reference: Fructose-1,6-bisphosphatase class 1

NADP-dependent malic enzyme
type: Protein
entity reference: NADP-dependent malic enzyme

Reference/KEGG Compound C00597
type: UnificationXref
id: C00597
db: KEGG Compound

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

2,3-bisphosphoglycerate-independent phosphoglycerate mutase
type: Protein
entity reference: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Reference/KEGG Compound C00354
type: UnificationXref
id: C00354
db: KEGG Compound

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

ChemicalStructure/PW C001906
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

3-Phosphoglyceric acid
type: SmallMolecule
entity reference: 3-Phosphoglyceric acid

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

DcuC
type: Protein
entity reference: DcuC

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Compound/PW C000148 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

C4-dicarboxylate transporter DcuB
type: Protein
entity reference: C4-dicarboxylate transporter DcuB

Protein/29184 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Pyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyruvic acid

Reference/ChemSpider 388538
type: UnificationXref
id: 388538
db: ChemSpider

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reaction746839
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADH
right: Hydrogen Ion
right: Oxalacetic acid
spontaneous: false
left: L-Malic acid
left: NAD
name: L-Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid
conversion direction: REVERSIBLE

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/SMPDB SMP0399295
type: UnificationXref
id: SMP0399295
db: SMPDB

Reference/ChEBI CHEBI 17138
type: UnificationXref
id: CHEBI:17138
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/KEGG Compound C00149
type: UnificationXref
id: C00149
db: KEGG Compound

D-Glyceraldehyde 3-phosphate
type: SmallMolecule
entity reference: D-Glyceraldehyde 3-phosphate

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Glyceric acid 1,3-biphosphate
type: SmallMolecule
entity reference: Glyceric acid 1,3-biphosphate

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Compound/PW C000644/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Phosphoglyceric acid
stoichiometric coefficient: 1.0

Compound/PW C001906 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-D-Glucose 6-phosphate
stoichiometric coefficient: 1.0

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/UniProt M5IPM2
type: UnificationXref
id: M5IPM2
db: UniProt

Reference/UniProt M5IPY5
type: UnificationXref
id: M5IPY5
db: UniProt

Protein/53623/Stoichiometry/4.0
type: Stoichiometry
physical entity: Fructose-1,6-bisphosphatase class 1
stoichiometric coefficient: 4.0

Reference/KEGG Compound C00036
type: UnificationXref
id: C00036
db: KEGG Compound

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Water
type: SmallMolecule
entity reference: Water

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

Reaction746858
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000983/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869/Stoichiometry/1.0
right: D-Glyceraldehyde 3-phosphate
right: NAD
right: Phosphate
spontaneous: false
left: NADH
left: Hydrogen Ion
left: Glyceric acid 1,3-biphosphate
name: Glyceric acid 1,3-biphosphate + Hydrogen Ion + NADH → D-Glyceraldehyde 3-phosphate + NAD + Phosphate
conversion direction: LEFT_TO_RIGHT

Oxalacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxalacetic acid

Reaction746854
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000983/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000644/Stoichiometry/1.0
right: Adenosine diphosphate
right: Glyceric acid 1,3-biphosphate
spontaneous: false
left: 3-Phosphoglyceric acid
left: Adenosine triphosphate
name: 3-Phosphoglyceric acid + Adenosine triphosphate → Adenosine diphosphate + Glyceric acid 1,3-biphosphate
conversion direction: LEFT_TO_RIGHT

dicarboxylate transporter
type: Complex
component: Unknown
component: DcuC
component: C4-dicarboxylate transporter DcuB

Reaction746851
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000262/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000644/Stoichiometry/1.0
right: 3-Phosphoglyceric acid
spontaneous: false
left: 2-Phosphoglyceric acid
name: 2-Phosphoglyceric acid → 3-Phosphoglyceric acid
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/UniProt M5IM11
type: UnificationXref
id: M5IM11
db: UniProt

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

Reference/ChemSpider 648
type: UnificationXref
id: 648
db: ChemSpider

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001112
type: UnificationXref
id: HMDB0001112
db: HMDB

Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
type: UnificationXref
id: PHOSPHO-ENOL-PYRUVATE
db: BioCyc

Reaction746848
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000262/Stoichiometry/1.0
right: 2-Phosphoglyceric acid
right: Water
spontaneous: false
left: Phosphoenolpyruvic acid
name: Phosphoenolpyruvic acid → 2-Phosphoglyceric acid + Water
conversion direction: LEFT_TO_RIGHT

1.1.1.38
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
right: NADH
right: Pyruvic acid
right: Carbon dioxide
spontaneous: false
EC number: 1.1.1.38
left: L-Malic acid
left: NAD
name: L-Malic acid + NAD → Carbon dioxide + NADH + Pyruvic acid
conversion direction: LEFT_TO_RIGHT

2.7.9.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: Water
right: Pyruvic acid
right: Adenosine triphosphate
spontaneous: false
EC number: 2.7.9.2
left: Hydrogen Ion
left: Adenosine monophosphate
left: Phosphoenolpyruvic acid
left: Phosphate
name: Adenosine monophosphate + 2 Hydrogen Ion + Phosphate + Phosphoenolpyruvic acid → Adenosine triphosphate + Pyruvic acid + Water
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000263
type: UnificationXref
id: HMDB0000263
db: HMDB

ChemicalStructure/PW C000180
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=C)OP(O)(O)=O

Reference/HMDB HMDB0001473
type: UnificationXref
id: HMDB0001473
db: HMDB

3-Phosphoglyceric acid
type: SmallMoleculeReference
xref: Reference/BioCyc G3P
xref: Reference/PubChem-compound 724
xref: Reference/ChEBI CHEBI 17050
xref: Reference/ChemSpider 704
xref: Reference/CAS 820-11-1
xref: Reference/KEGG Compound C00597
xref: Reference/HMDB HMDB0000807
chemical formula: C3H7O7P
molecular weight: 185.99294
structure: ChemicalStructure/PW C000644

Reference/PubChem-compound 668
type: UnificationXref
id: 668
db: PubChem-compound

β-D-fructofuranose 6-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: β-D-fructofuranose 6-phosphate

ChemicalStructure/PW C000148
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

Compound/PW C000164/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/CAS 591-59-3
type: UnificationXref
id: 591-59-3
db: CAS

Reference/HMDB HMDB0000156
type: UnificationXref
id: HMDB0000156
db: HMDB

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Compound/PW C001134/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroxyacetone phosphate
stoichiometric coefficient: 1.0

5.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040941 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001906 Cytoplasm/Stoichiometry/1.0
right: β-D-Glucose 6-phosphate
spontaneous: false
EC number: 5.3.1.9
left: β-D-fructofuranose 6-phosphate
name: β-D-fructofuranose 6-phosphate → β-D-Glucose 6-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/UniProt M5IHJ2
type: UnificationXref
id: M5IHJ2
db: UniProt

Protein/53622/Stoichiometry/4.0
type: Stoichiometry
physical entity: Glyceraldehyde-3-phosphate dehydrogenase
stoichiometric coefficient: 4.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/BioCyc DPG
type: UnificationXref
id: DPG
db: BioCyc

Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
type: UnificationXref
id: DIHYDROXY-ACETONE-PHOSPHATE
db: BioCyc

Reference/UniProt M5ITA4
type: UnificationXref
id: M5ITA4
db: UniProt

Compound/PW C000174 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Putative C4-dicarboxylate transport protein
type: ProteinReference
xref: Reference/UniProt M5ISE9

Reference/PubChem-compound 445557
type: UnificationXref
id: 445557
db: PubChem-compound

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/ChemSpider 663
type: UnificationXref
id: 663
db: ChemSpider

Reference/KEGG Compound C00074
type: UnificationXref
id: C00074
db: KEGG Compound

Reference/ChEBI CHEBI 17050
type: UnificationXref
id: CHEBI:17050
db: ChEBI

5.3.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
right: Dihydroxyacetone phosphate
spontaneous: false
EC number: 5.3.1.1
left: D-Glyceraldehyde 3-phosphate
name: D-Glyceraldehyde 3-phosphate ↔ Dihydroxyacetone phosphate
conversion direction: REVERSIBLE

Compound/PW C000101 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Malic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001134
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)COP(O)(O)=O

1.1.1.40
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Cytosol/Stoichiometry/1.0
right: Pyruvic acid
right: Carbon dioxide
right: NADPH
spontaneous: false
EC number: 1.1.1.40
left: L-Malic acid
left: NADP
name: L-Malic acid + NADP → Carbon dioxide + NADPH + Pyruvic acid
conversion direction: LEFT_TO_RIGHT

4.1.1.49
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Carbon dioxide
right: Phosphoenolpyruvic acid
spontaneous: false
EC number: 4.1.1.49
left: Adenosine triphosphate
left: Oxalacetic acid
name: Adenosine triphosphate + Oxalacetic acid → Adenosine diphosphate + Carbon dioxide + Phosphoenolpyruvic acid
conversion direction: LEFT_TO_RIGHT

4.1.2.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000833/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869/Stoichiometry/1.0
right: Fructose 1,6-bisphosphate
spontaneous: false
EC number: 4.1.2.13
left: Dihydroxyacetone phosphate
left: D-Glyceraldehyde 3-phosphate
name: D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate → Fructose 1,6-bisphosphate
conversion direction: LEFT_TO_RIGHT

3.1.3.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040941/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000833/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: β-D-fructofuranose 6-phosphate
right: Phosphate
spontaneous: false
EC number: 3.1.3.11
left: Water
left: Fructose 1,6-bisphosphate
name: Fructose 1,6-bisphosphate + Water → Phosphate + β-D-fructofuranose 6-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/PubChem-compound 724
type: UnificationXref
id: 724
db: PubChem-compound

ChemicalStructure/PW C040941
type: ChemicalStructure
structure format: SMILES
structure data: OCC1(O)OC(COP([O-])([O-])=O)C(O)C1O

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Compound/PW C000262/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Phosphoglyceric acid
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
entity reference: Phosphate

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Periplasmic Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005620

Reference/KEGG Compound C01172
type: UnificationXref
id: C01172
db: KEGG Compound

Reference/PubChem-compound 729
type: UnificationXref
id: 729
db: PubChem-compound

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 44897
type: UnificationXref
id: CHEBI:44897
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/BioCyc G3P
type: UnificationXref
id: G3P
db: BioCyc

Reference/HMDB HMDB0001270
type: UnificationXref
id: HMDB0001270
db: HMDB

Compound/PW C000869/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glyceraldehyde 3-phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Compound/PW C000869 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glyceraldehyde 3-phosphate
stoichiometric coefficient: 1.0

Protein/53624 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glucose-6-phosphate isomerase
stoichiometric coefficient: 2.0

Reference/BioCyc 2-PG
type: UnificationXref
id: 2-PG
db: BioCyc

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/ChemSpider 393165
type: UnificationXref
id: 393165
db: ChemSpider

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Reference/PubChem-compound 970
type: UnificationXref
id: 970
db: PubChem-compound

Reference/ChEBI CHEBI 57634
type: UnificationXref
id: CHEBI:57634
db: ChEBI

Reference/HMDB HMDB0001058
type: UnificationXref
id: HMDB0001058
db: HMDB

L-Malic acid
type: SmallMolecule
entity reference: L-Malic acid

Reference/ChemSpider 980
type: UnificationXref
id: 980
db: ChemSpider

L-Malic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000156
xref: Reference/ChEBI CHEBI 30797
xref: Reference/KEGG Compound C00149
xref: Reference/ChemSpider 193317
xref: Reference/PubChem-compound 222656
xref: Reference/CAS 97-67-6
chemical formula: C4H6O5
molecular weight: 134.02153
structure: ChemicalStructure/PW C000101

Reference/CAS 820-11-1
type: UnificationXref
id: 820-11-1
db: CAS

Compound/PW C001134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroxyacetone phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Oxalacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000223
xref: Reference/CAS 328-42-7
xref: Reference/ChEBI CHEBI 30744
xref: Reference/BioCyc OXALACETIC ACID
xref: Reference/ChemSpider 945
xref: Reference/PubChem-compound 970
xref: Reference/KEGG Compound C00036
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C000148

ReactionCatalysis747979
type: Catalysis
controller: Unknown
controlled: 4.1.1.49
control type: ACTIVATION

ReactionCatalysis747977
type: Catalysis
controller: malate dehydrogenase B
controlled: 1.1.1.40
control type: ACTIVATION

ReactionCatalysis747974
type: Catalysis
controller: fructose-1,6-bisphosphatase
controlled: 3.1.3.11
control type: ACTIVATION

ReactionCatalysis747972
type: Catalysis
controller: fructose bisphosphate aldolase class II
controlled: 4.1.2.13
control type: ACTIVATION

NADH
type: SmallMolecule
entity reference: NADH

ReactionCatalysis747971
type: Catalysis
controller: fructose bisphosphate aldolase class I
controlled: 4.1.2.13
control type: ACTIVATION

malate dehydrogenase, NAD-requiring
type: Complex
component stoichiometry: Protein/53620/Stoichiometry/4.0
component: NADP-dependent malic enzyme

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

β-D-Glucose 6-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: β-D-Glucose 6-phosphate

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Compound/PW C000180 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/UniProt M5ISE9
type: UnificationXref
id: M5ISE9
db: UniProt

Reference/PubChem-compound 1005
type: UnificationXref
id: 1005
db: PubChem-compound

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

ReactionCatalysis747983
type: Catalysis
controller: phosphoglucose isomerase
controlled: 5.3.1.9
control type: ACTIVATION

Campylobacter showae CSUNSWCD
type: BioSource
xref: Reference/TAXONOMY 1244083

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 1981-49-3
type: UnificationXref
id: 1981-49-3
db: CAS

fructose bisphosphate aldolase class I
type: Complex
component stoichiometry: Protein/29184/Stoichiometry/10.0
component: Unknown

Dihydroxyacetone phosphate
type: SmallMolecule
entity reference: Dihydroxyacetone phosphate

ReactionCatalysis747981
type: Catalysis
controller: triosephosphate isomerase
controlled: 5.3.1.1
control type: ACTIVATION

Glucose-6-phosphate isomerase
type: ProteinReference
xref: Reference/UniProt M5ITA4
organism: Campylobacter showae CSUNSWCD

Glyceraldehyde 3-phosphate dehydrogenase
type: Complex
component stoichiometry: Protein/53622/Stoichiometry/4.0
component: Glyceraldehyde-3-phosphate dehydrogenase

Fructose-1,6-bisphosphatase class 1
type: ProteinReference
xref: Reference/UniProt M5IHJ2

Reference/CAS 328-42-7
type: UnificationXref
id: 328-42-7
db: CAS

Compound/PW C000180/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvic acid
stoichiometric coefficient: 1.0

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: Reference/UniProt M5IM11

fructose-1,6-bisphosphatase
type: Complex
component stoichiometry: Protein/29184/Stoichiometry/2.0
component stoichiometry: Protein/53623/Stoichiometry/4.0
component: Unknown
component: Fructose-1,6-bisphosphatase class 1

2,3-bisphosphoglycerate-independent phosphoglycerate mutase
type: ProteinReference
xref: Reference/UniProt M5IS85

Dihydroxyacetone phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
xref: Reference/PubChem-compound 668
xref: Reference/ChEBI CHEBI 16108
xref: Reference/KEGG Compound C00111
xref: Reference/CAS 57-04-5
xref: Reference/ChemSpider 648
xref: Reference/HMDB HMDB0001473
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C001134

fructose bisphosphate aldolase class II
type: Complex
component stoichiometry: Protein/29184/Stoichiometry/2.0
component: Unknown

ChemicalStructure/PW C000101
type: ChemicalStructure
structure format: SMILES
structure data: O[C@@H](CC(O)=O)C(O)=O

NADP-dependent malic enzyme
type: ProteinReference
xref: Reference/UniProt M5IPY5

Pyruvic acid
type: SmallMolecule
entity reference: Pyruvic acid

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Succinic acid
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Succinic acid

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Reference/PubChem-compound 59
type: UnificationXref
id: 59
db: PubChem-compound

C4-dicarboxylate transporter DcuB
type: ProteinReference
xref: Reference/UniProt M5IPM2

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

DcuC
type: ProteinReference
xref: Reference/UniProt M5ILT0

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

Reference/ChEBI CHEBI 16905
type: UnificationXref
id: CHEBI:16905
db: ChEBI

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Oxalacetic acid
type: SmallMolecule
entity reference: Oxalacetic acid

2-Phosphoglyceric acid
type: SmallMolecule
entity reference: 2-Phosphoglyceric acid

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reference/PathWhiz PW000821
type: UnificationXref
id: PW000821
db: PathWhiz

2-Phosphoglyceric acid
type: SmallMoleculeReference
xref: Reference/CAS 2553-59-5
xref: Reference/ChemSpider 58
xref: Reference/BioCyc 2-PG
xref: Reference/ChEBI CHEBI 24344
xref: Reference/PubChem-compound 59
xref: Reference/HMDB HMDB0000362
chemical formula: C3H7O7P
molecular weight: 185.99294
structure: ChemicalStructure/PW C000262

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Reference/PubChem-compound 683
type: UnificationXref
id: 683
db: PubChem-compound

L-Malic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Malic acid

Phosphoenolpyruvic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoenolpyruvic acid

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

β-D-fructofuranose 6-phosphate
type: SmallMolecule
entity reference: β-D-fructofuranose 6-phosphate

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/UniProt M5ILT0
type: UnificationXref
id: M5ILT0
db: UniProt

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000262
type: ChemicalStructure
structure format: SMILES
structure data: OCC(OP(O)(O)=O)C(O)=O

Reference/HMDB HMDB0000223
type: UnificationXref
id: HMDB0000223
db: HMDB

Compound/PW C040941/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-D-fructofuranose 6-phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Compound/PW C000164 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/CAS 57-04-5
type: UnificationXref
id: 57-04-5
db: CAS

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

Compound/PW C000174 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

β-D-fructofuranose 6-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 57634
chemical formula: C6H11O9P
molecular weight: 258.01517
structure: ChemicalStructure/PW C040941

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

TransportCatalysis37146
type: Catalysis
controller: dicarboxylate transporter
controlled: Transport56136
control type: ACTIVATION

TransportCatalysis37145
type: Catalysis
controller: Putative C4-dicarboxylate transport protein
controlled: Transport56135
control type: ACTIVATION

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005620
type: UnificationXref
id: GO:0005620
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 24344
type: UnificationXref
id: CHEBI:24344
db: ChEBI

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

malate dehydrogenase B
type: Complex
component stoichiometry: Protein/29184 Cytosol/Stoichiometry/6.0
cellular location: Cytosol
component: Unknown

Reference/PathWhiz PW410240
type: UnificationXref
id: PW410240
db: PathWhiz

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

SubPathwayInteraction407480
type: Interaction
name: SubPathwayReaction
name: SubPathway407480Reaction
participant: β-D-Glucose 6-phosphate

Phosphoenolpyruvic acid
type: SmallMoleculeReference
xref: Reference/CAS 138-08-9
xref: Reference/ChEBI CHEBI 44897
xref: Reference/KEGG Compound C00074
xref: Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
xref: Reference/ChemSpider 980
xref: Reference/PubChem-compound 1005
xref: Reference/HMDB HMDB0000263
chemical formula: C3H5O6P
molecular weight: 167.98238
structure: ChemicalStructure/PW C000180

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

D-Glyceraldehyde 3-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glyceraldehyde 3-phosphate

Phosphoenolpyruvic acid
type: SmallMolecule
entity reference: Phosphoenolpyruvic acid

Reference/HMDB HMDB0000362
type: UnificationXref
id: HMDB0000362
db: HMDB

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Compound/PW C040941 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-D-fructofuranose 6-phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/HMDB HMDB0000807
type: UnificationXref
id: HMDB0000807
db: HMDB

Dihydroxyacetone phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydroxyacetone phosphate

Reference/PubChem-compound 222656
type: UnificationXref
id: 222656
db: PubChem-compound

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

ChemicalStructure/PW C000983
type: ChemicalStructure
structure format: SMILES
structure data: O[C@H](COP(O)(O)=O)C(=O)OP(O)(O)=O

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Compound/PW C000833/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose 1,6-bisphosphate
stoichiometric coefficient: 1.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Reference/PubChem-compound 439427
type: UnificationXref
id: 439427
db: PubChem-compound

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

β-D-Glucose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: β-D-Glucose 6-phosphate
name: SubPathwayInput

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

enolase
type: Complex
component stoichiometry: Protein/29184/Stoichiometry/2.0
component: Unknown

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/ChEBI CHEBI 17719
type: UnificationXref
id: CHEBI:17719
db: ChEBI

Reference/BioCyc FRUCTOSE-16-DIPHOSPHATE
type: UnificationXref
id: FRUCTOSE-16-DIPHOSPHATE
db: BioCyc

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

ChemicalStructure/PW C000833
type: ChemicalStructure
structure format: SMILES

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

phosphoenolpyruvate synthetase
type: Complex
component stoichiometry: Protein/29184/Stoichiometry/2.0
component: Unknown

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Compound/PW C000101 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Malic acid
stoichiometric coefficient: 1.0

Putative C4-dicarboxylate transport protein
type: Protein
entity reference: Putative C4-dicarboxylate transport protein

Succinic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Succinic acid

ChemicalStructure/PW C000644
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C(O)=O

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Compound/PW C000983/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyceric acid 1,3-biphosphate
stoichiometric coefficient: 1.0

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Unknown
type: Protein
entity reference: Unknown

Reference/ChEBI CHEBI 16108
type: UnificationXref
id: CHEBI:16108
db: ChEBI

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/ChEBI CHEBI 30744
type: UnificationXref
id: CHEBI:30744
db: ChEBI

Protein/29184 Cytosol/Stoichiometry/6.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 6.0

Gluconeogenesis from L-Malic Acid
type: Pathway
pathway order: PathwayEnzymeReaction/5825924
pathway order: PathwayEnzymeReaction/5825954
pathway order: PathwayEnzymeReaction/5825933
pathway order: PathwayEnzymeReaction/5825944
pathway order: PathwayEnzymeReaction/5825930
pathway order: PathwayEnzymeReaction/5825941
pathway order: PathwayEnzymeReaction/5825952
pathway order: PathwayEnzymeReaction/5825920
pathway order: PathwayEnzymeReaction/5825942
pathway order: PathwayTransport/5825955
pathway order: PathwayTransport/5825957
pathway order: PathwayEnzymeReaction/5825916
pathway order: PathwayEnzymeReaction/5825927
pathway order: PathwayEnzymeReaction/5825938
pathway order: PathwayEnzymeReaction/5825949
pathway order: PathwaySubPathway/407480
pathway order: PathwayEnzymeReaction/5825947
pathway component: ReactionCatalysis747959
pathway component: ReactionCatalysis747979
pathway component: ReactionCatalysis747956
pathway component: ReactionCatalysis747977
pathway component: ReactionCatalysis747954
pathway component: ReactionCatalysis747974
pathway component: Reaction746839
pathway component: ReactionCatalysis747950
pathway component: ReactionCatalysis747972
pathway component: TransportCatalysis37146
pathway component: ReactionCatalysis747971
pathway component: TransportCatalysis37145
pathway component: Reaction746858
pathway component: Reaction746854
pathway component: 5.3.1.9
pathway component: Reaction746851
pathway component: Transport56136
pathway component: ReactionCatalysis747969
pathway component: ReactionCatalysis747965
pathway component: ReactionCatalysis747962
pathway component: ReactionCatalysis747983
pathway component: ReactionCatalysis747981
pathway component: 5.3.1.1
pathway component: Reaction746848
pathway component: 1.1.1.38
pathway component: 1.1.1.40
pathway component: Transport56135
pathway component: 2.7.9.2
pathway component: 4.1.1.49
pathway component: 4.1.2.13
pathway component: Galactose Metabolism
pathway component: 3.1.3.11
xref: Reference/PathWhiz PW410240
xref: Reference/SMPDB SMP0399295
organism: Campylobacter showae CSUNSWCD

Protein/53620/Stoichiometry/4.0
type: Stoichiometry
physical entity: NADP-dependent malic enzyme
stoichiometric coefficient: 4.0

ReactionCatalysis747959
type: Catalysis
controller: enolase
controlled: Reaction746848
control type: ACTIVATION

ReactionCatalysis747956
type: Catalysis
controller: phosphoenolpyruvate synthetase
controlled: 2.7.9.2
control type: ACTIVATION

ReactionCatalysis747954
type: Catalysis
controller: malate dehydrogenase, NAD-requiring
controlled: 1.1.1.38
control type: ACTIVATION

ChemicalStructure/PW C000869
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C=O

ReactionCatalysis747950
type: Catalysis
controller: Unknown
controlled: Reaction746839
control type: ACTIVATION

Reference/ChemSpider 193317
type: UnificationXref
id: 193317
db: ChemSpider

Compound/PW C000148/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Compound/PW C040034/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/BioCyc GAP
type: UnificationXref
id: GAP
db: BioCyc

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Protein/29184/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Hydrogen Ion
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Hydrogen Ion

Transport56136
type: Transport
participant stoichiometry: Compound/PW C000174 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Cytosol/Stoichiometry/1.0
right: Succinic acid
right: L-Malic acid
spontaneous: false
left: Succinic acid
left: L-Malic acid
name: L-Malic acid (→), Succinic acid (←) Transport: Campylobacter showae CSUNSWCD, Periplasmic Space to Campylobacter showae CSUNSWCD, Cytosol
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis747969
type: Catalysis
controller: Glyceraldehyde 3-phosphate dehydrogenase
controlled: Reaction746858
control type: ACTIVATION

Reference/KEGG Compound C00661
type: UnificationXref
id: C00661
db: KEGG Compound

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Glucose-6-phosphate isomerase
type: Protein
cellular location: Cytoplasm
entity reference: Glucose-6-phosphate isomerase

L-Malic acid
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: L-Malic acid

ReactionCatalysis747965
type: Catalysis
controller: Unknown
controlled: Reaction746854
control type: ACTIVATION

phosphoglucose isomerase
type: Complex
component stoichiometry: Protein/53624 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Glucose-6-phosphate isomerase

ReactionCatalysis747962
type: Catalysis
controller: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
controlled: Reaction746851
control type: ACTIVATION

Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Transport56135
type: Transport
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: L-Malic acid
spontaneous: false
left: Hydrogen Ion
left: L-Malic acid
name: L-Malic acid (→), Hydrogen Ion (→) Transport: Campylobacter showae CSUNSWCD, Periplasmic Space to Campylobacter showae CSUNSWCD, Cytosol
conversion direction: LEFT_TO_RIGHT