Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Compound/PW C001496/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uroporphyrinogen I
stoichiometric coefficient: 1.0

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Reference/KEGG Compound C00430
type: UnificationXref
id: C00430
db: KEGG Compound

Coproporphyrinogen III
type: SmallMolecule
entity reference: Coproporphyrinogen III

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Sugar ABC transporter inner membrane protein
type: ProteinReference
xref: Reference/UniProt J9UUX7

Reference/PubChem-compound 25245954
type: UnificationXref
id: 25245954
db: PubChem-compound

Uroporphyrinogen III
type: SmallMolecule
entity reference: Uroporphyrinogen III

Amino acid transport system permease
type: ProteinReference
xref: Reference/UniProt J9U9I0
organism: Brachyspira pilosicoli B2904

Reference/BioCyc COPROPORPHYRINOGEN I
type: UnificationXref
id: COPROPORPHYRINOGEN_I
db: BioCyc

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Reference/HMDB HMDB0002158
type: UnificationXref
id: HMDB0002158
db: HMDB

Compound/PW C001065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/BioCyc HYDROXYMETHYLBILANE
type: UnificationXref
id: HYDROXYMETHYLBILANE
db: BioCyc

ChemicalStructure/PW C041682
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C041683
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Polar amino acid uptake ABC transporter amino acid-binding protein
type: ProteinReference
xref: Reference/UniProt J9TRJ6
organism: Brachyspira pilosicoli B2904

Reference/KEGG Compound C00448
type: UnificationXref
id: C00448
db: KEGG Compound

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

ChemicalStructure/PW C041684
type: ChemicalStructure
structure format: SMILES

Sodium/glutamate symporter
type: ProteinReference
xref: Reference/UniProt J9UEK5

NAD
type: SmallMolecule
entity reference: NAD

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 6137
type: UnificationXref
id: 6137
db: PubChem-compound

Ammonium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0041827
xref: Reference/CAS 14798-03-9
xref: Reference/PubChem-compound 16741146
xref: Reference/KEGG Compound C01342
xref: Reference/ChEBI CHEBI 28938
xref: Reference/ChemSpider 218
chemical formula: H4N
molecular weight: 18.034374
structure: ChemicalStructure/PW C022608

Reference/ChEBI CHEBI 28599
type: UnificationXref
id: CHEBI:28599
db: ChEBI

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/SMPDB SMP0434575
type: UnificationXref
id: SMP0434575
db: SMPDB

Reference/ChemSpider 1146
type: UnificationXref
id: 1146
db: ChemSpider

ChemicalStructure/PW C041459
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(CCC(O)=O)/C2=C/C3=C(CCC(O)=O)C(C)=C(N3)\C=C3/N=C(/C=C4\N=C(\C=C\1/N\2)C(=O)C4(C)CC(O)=O)C(=O)C3(C)CC(O)=O

Reference/TAXONOMY 1133568
type: UnificationXref
id: 1133568
db: TAXONOMY

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Reference/UniProt J9UBG5
type: UnificationXref
id: J9UBG5
db: UniProt

Compound/PW C000166/Stoichiometry/4.0
type: Stoichiometry
physical entity: Porphobilinogen
stoichiometric coefficient: 4.0

Reference/PubChem-compound 439182
type: UnificationXref
id: 439182
db: PubChem-compound

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/HMDB HMDB0001086
type: UnificationXref
id: HMDB0001086
db: HMDB

ChemicalStructure/PW C041220
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

ChemicalStructure/PW C041228
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C041227
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/PubChem-compound 445713
type: UnificationXref
id: 445713
db: PubChem-compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Protein/75701/Stoichiometry/8.0
type: Stoichiometry
physical entity: Probable transaldolase
stoichiometric coefficient: 8.0

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/UniProt J9TRJ6
type: UnificationXref
id: J9TRJ6
db: UniProt

Reference/HMDB HMDB0001097
type: UnificationXref
id: HMDB0001097
db: HMDB

Reference/ChemSpider 389645
type: UnificationXref
id: 389645
db: ChemSpider

Reference/ChemSpider 389644
type: UnificationXref
id: 389644
db: ChemSpider

Ammonium
type: SmallMolecule
entity reference: Ammonium

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Protoporphyrinogen IX
type: SmallMoleculeReference
xref: Reference/CAS 7412-77-3
xref: Reference/ChemSpider 108741
xref: Reference/BioCyc PROTOPORPHYRINOGEN
xref: Reference/ChEBI CHEBI 15435
xref: Reference/KEGG Compound C01079
xref: Reference/PubChem-compound 121893
xref: Reference/HMDB HMDB0001097
chemical formula: C34H40N4O4
molecular weight: 568.30493
structure: ChemicalStructure/PW C000863

Heme D
type: SmallMoleculeReference
xref: Reference/PubChem-compound 3582
chemical formula: C34H34N4O10
molecular weight: 658.2275
structure: ChemicalStructure/PW C041459

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Reference/ChEBI CHEBI 17381
type: UnificationXref
id: CHEBI:17381
db: ChEBI

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

5-Aminolevulinic acid
type: SmallMolecule
entity reference: 5-Aminolevulinic acid

Reference/UniProt J9UEK5
type: UnificationXref
id: J9UEK5
db: UniProt

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

Compound/PW C041228/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sirohydrochlorin
stoichiometric coefficient: 1.0

Compound/PW C000854/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uroporphyrinogen III
stoichiometric coefficient: 1.0

Reaction3479
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000887/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001496/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
right: Uroporphyrinogen I
right: Water
spontaneous: true
left: Hydroxymethylbilane
name: Hydroxymethylbilane → Uroporphyrinogen I + Water
conversion direction: LEFT_TO_RIGHT

Precorrin 2
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 50602
xref: Reference/PubChem-compound 5280516
chemical formula: C42H46N4O16
molecular weight: 862.2909
structure: ChemicalStructure/PW C041220

Reference/ChemSpider 388325
type: UnificationXref
id: 388325
db: ChemSpider

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Siroheme
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28599
xref: Reference/PubChem-compound 439303
chemical formula: C42H44FeN4O16
molecular weight: 916.21014
structure: ChemicalStructure/PW C041227

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Sirohydrochlorin
type: SmallMoleculeReference
xref: Reference/PubChem-compound 196427
xref: Reference/ChEBI CHEBI 18023
chemical formula: C42H46N4O16
molecular weight: 862.2909
structure: ChemicalStructure/PW C041228

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Farnesyl pyrophosphate
type: SmallMolecule
entity reference: Farnesyl pyrophosphate

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Hydroxymethylbilane
type: SmallMolecule
entity reference: Hydroxymethylbilane

Reference/UniProt J9UDJ2
type: UnificationXref
id: J9UDJ2
db: UniProt

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Compound/PW C001783/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01342
type: UnificationXref
id: C01342
db: KEGG Compound

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

ChemicalStructure/PW C042627
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

ChemicalStructure/PW C000900
type: ChemicalStructure
structure format: SMILES

Protein/33940/Stoichiometry/4.0
type: Stoichiometry
physical entity: Catalase
stoichiometric coefficient: 4.0

Reference/PubChem-compound 25244684
type: UnificationXref
id: 25244684
db: PubChem-compound

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

TransportCatalysis23767
type: Catalysis
controller: Na/H dicarboxylate symporters putative
controlled: Transport41012
control type: ACTIVATION

TransportCatalysis23768
type: Catalysis
controller: Sodium/glutamate symporter
controlled: Transport41013
control type: ACTIVATION

L-Glutamate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway463917
pathway component: SubPathwayInteraction463917
xref: Reference/SMPDB SMP0000811
xref: Reference/PathWhiz PW000789
name: SubPathway

Compound/PW C001329/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5'-Deoxyadenosine
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

S-Adenosylhomocysteine
type: SmallMolecule
entity reference: S-Adenosylhomocysteine

Sulfur Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway463918
pathway component: SubPathwayInteraction463918
xref: Reference/PathWhiz PW000922
xref: Reference/SMPDB SMP0000939
name: SubPathway

Uroporphyrinogen III
type: SmallMoleculeReference
xref: Reference/ChemSpider 1146
xref: Reference/KEGG Compound C01051
xref: Reference/CAS 1976-85-8
xref: Reference/BioCyc UROPORPHYRINOGEN-III
xref: Reference/ChEBI CHEBI 15437
xref: Reference/PubChem-compound 1179
xref: Reference/HMDB HMDB0001086
chemical formula: C40H44N4O16
molecular weight: 836.2752
structure: ChemicalStructure/PW C000854

Coproporphyrinogen III
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03263
xref: Reference/ChEBI CHEBI 15439
xref: Reference/HMDB HMDB0001261
xref: Reference/BioCyc COPROPORPHYRINOGEN III
xref: Reference/PubChem-compound 321
xref: Reference/CAS 2624-63-7
xref: Reference/ChemSpider 315
chemical formula: C36H44N4O8
molecular weight: 660.3159
structure: ChemicalStructure/PW C000974

Oxidative Phosphorylation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway463919
pathway order: SubPathwayInteractionSteps/SubPathway463921
pathway order: SubPathwayInteractionSteps/SubPathway463920
pathway component: SubPathwayInteraction463919
pathway component: SubPathwayInteraction463921
pathway component: SubPathwayInteraction463920
xref: Reference/SMPDB SMP0000936
xref: Reference/PathWhiz PW000919
name: SubPathway

Protoporphyrinogen IX
type: SmallMolecule
entity reference: Protoporphyrinogen IX

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/BioCyc MET
type: UnificationXref
id: MET
db: BioCyc

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

Compound/PW C000458 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/CAS 553-12-8
type: UnificationXref
id: 553-12-8
db: CAS

Compound/PW C000921/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Compound/PW C000163/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protoporphyrin IX
stoichiometric coefficient: 1.0

Reference/UniProt J9USE6
type: UnificationXref
id: J9USE6
db: UniProt

Compound/PW C000414/Stoichiometry/8.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 8.0

Unknown
type: ProteinReference

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Na/H dicarboxylate symporters putative
type: ProteinReference
xref: Reference/UniProt J9UXB3

L-Methionine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000696
xref: Reference/ChEBI CHEBI 16643
xref: Reference/KEGG Compound C00073
xref: Reference/CAS 63-68-3
xref: Reference/BioCyc MET
xref: Reference/PubChem-compound 6137
xref: Reference/ChemSpider 5907
chemical formula: C5H11NO2S
molecular weight: 149.05106
structure: ChemicalStructure/PW C000548

Fe2+
type: SmallMoleculeReference
xref: Reference/CAS 15438-31-0
xref: Reference/KEGG Compound C14818
xref: Reference/ChemSpider 25394
xref: Reference/PubChem-compound 27284
xref: Reference/ChEBI CHEBI 29033
xref: Reference/BioCyc Ferric-Hydroxamate-Complexes
xref: Reference/HMDB HMDB0000692
chemical formula: Fe
molecular weight: 55.93494
structure: ChemicalStructure/PW C000544

Compound/PW C041682/Stoichiometry/1.0
type: Stoichiometry
physical entity: Menaquinol 6
stoichiometric coefficient: 1.0

Reference/CAS 73023-76-4
type: UnificationXref
id: 73023-76-4
db: CAS

Reference/CAS 372-97-4
type: UnificationXref
id: 372-97-4
db: CAS

Reference/ChEBI CHEBI 18151
type: UnificationXref
id: CHEBI:18151
db: ChEBI

ChemicalStructure/PW C042924
type: ChemicalStructure
structure format: SMILES
structure data: [Fe].CC1=C(CCC([O-])=O)C2=N\C\1=C/C1=C(C=C)C(C)=C([N-]1)\C=C1/[N-]\C(=C/C3=N/C(=C\2)/C(CCC([O-])=O)=C3C)C(C)=C1C=C

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Water
type: SmallMolecule
entity reference: Water

Hydrogen peroxide
type: SmallMolecule
entity reference: Hydrogen peroxide

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Compound/PW C000544/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fe2+
stoichiometric coefficient: 1.0

ReactionCoupledTransportCatalysis7182
type: Catalysis
controller: glutamate / aspartate ABC transporter
controlled: ReactionCoupledTransport7120
control type: ACTIVATION

Reference/ChEBI CHEBI 29175
type: UnificationXref
id: CHEBI:29175
db: ChEBI

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/SMPDB SMP0000936
type: UnificationXref
id: SMP0000936
db: SMPDB

Reference/SMPDB SMP0000811
type: UnificationXref
id: SMP0000811
db: SMPDB

ChemicalStructure/PW C042930
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@](N)(CCC(O)=O)C=O

Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
type: Protein
entity reference: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Reference/SMPDB SMP0000939
type: UnificationXref
id: SMP0000939
db: SMPDB

Reference/ChemSpider 767
type: UnificationXref
id: 767
db: ChemSpider

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Compound/PW C000863/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protoporphyrinogen IX
stoichiometric coefficient: 1.0

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Compound/PW C000974/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coproporphyrinogen III
stoichiometric coefficient: 1.0

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Farnesyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00448
xref: Reference/HMDB HMDB0000961
xref: Reference/ChemSpider 393270
xref: Reference/ChEBI CHEBI 17407
xref: Reference/CAS 372-97-4
xref: Reference/BioCyc FARNESYL-PP
xref: Reference/PubChem-compound 445713
chemical formula: C15H28O7P2
molecular weight: 382.13104
structure: ChemicalStructure/PW C000768

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Hydroxymethylbilane
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001137
xref: Reference/ChEBI CHEBI 16645
xref: Reference/PubChem-compound 788
xref: Reference/KEGG Compound C01024
xref: Reference/CAS 73023-76-4
xref: Reference/BioCyc HYDROXYMETHYLBILANE
xref: Reference/ChemSpider 767
chemical formula: C40H46N4O17
molecular weight: 854.28577
structure: ChemicalStructure/PW C000887

Reference/KEGG Compound C15672
type: UnificationXref
id: C15672
db: KEGG Compound

Reference/PubChem-compound 788
type: UnificationXref
id: 788
db: PubChem-compound

Reference/KEGG Compound C01024
type: UnificationXref
id: C01024
db: KEGG Compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C000900/Stoichiometry/1.0
type: Stoichiometry
physical entity: Heme O
stoichiometric coefficient: 1.0

Reference/ChemSpider 315
type: UnificationXref
id: 315
db: ChemSpider

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc PROTOPORPHYRINOGEN
type: UnificationXref
id: PROTOPORPHYRINOGEN
db: BioCyc

Reference/UniProt J9UVF7
type: UnificationXref
id: J9UVF7
db: UniProt

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

5-Aminolevulinic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 137
xref: Reference/BioCyc 5-AMINO-LEVULINATE
xref: Reference/ChEBI CHEBI 17549
xref: Reference/ChemSpider 134
xref: Reference/HMDB HMDB0001149
xref: Reference/KEGG Compound C00430
xref: Reference/CAS 106-60-5
chemical formula: C5H9NO3
molecular weight: 131.05824
structure: ChemicalStructure/PW C000894

Amino acid transport system permease
type: Protein
cellular location: Inner Membrane
entity reference: Amino acid transport system permease

Reference/CAS 63-68-3
type: UnificationXref
id: 63-68-3
db: CAS

Reference/ChEBI CHEBI 29033
type: UnificationXref
id: CHEBI:29033
db: ChEBI

Reference/HMDB HMDB0002211
type: UnificationXref
id: HMDB0002211
db: HMDB

Reference/ChEBI CHEBI 29157
type: UnificationXref
id: CHEBI:29157
db: ChEBI

Reference/ChemSpider 5907
type: UnificationXref
id: 5907
db: ChemSpider

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Fe2+
type: SmallMolecule
entity reference: Fe2+

Reference/BioCyc FARNESYL-PP
type: UnificationXref
id: FARNESYL-PP
db: BioCyc

L-Methionine
type: SmallMolecule
entity reference: L-Methionine

Reference/ChEBI CHEBI 18023
type: UnificationXref
id: CHEBI:18023
db: ChEBI

L-Glutamic acid
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: L-Glutamic acid

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

ChemicalStructure/PW C001496
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/HMDB HMDB0001137
type: UnificationXref
id: HMDB0001137
db: HMDB

ChemicalStructure/PW C000163
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(CCC(O)=O)/C2=C/C3=N/C(=C\C4=C(C)C(C=C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C=C)=C4C)/C(C)=C3CCC(O)=O

Compound/PW C001420/Stoichiometry/8.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 8.0

Reference/KEGG Compound C00073
type: UnificationXref
id: C00073
db: KEGG Compound

ChemicalStructure/PW C000166
type: ChemicalStructure
structure format: SMILES
structure data: NCC1=C(CC(O)=O)C(CCC(O)=O)=CN1

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Reference/BioCyc UROPORPHYRINOGEN-III
type: UnificationXref
id: UROPORPHYRINOGEN-III
db: BioCyc

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/PubChem-compound 121893
type: UnificationXref
id: 121893
db: PubChem-compound

Reference/KEGG Compound C05766
type: UnificationXref
id: C05766
db: KEGG Compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/KEGG Compound C05768
type: UnificationXref
id: C05768
db: KEGG Compound

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Reaction982925
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001496/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/4.0
participant stoichiometry: Compound/PW C001451/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/4.0
right: Coproporphyrinogen I
right: Carbon dioxide
spontaneous: false
left: Uroporphyrinogen I
left: Hydrogen Ion
name: 4 Hydrogen Ion + Uroporphyrinogen I → 4 Carbon dioxide + Coproporphyrinogen I
conversion direction: LEFT_TO_RIGHT

1.3.5.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000863/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000163/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041683/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041682/Stoichiometry/1.0
right: Protoporphyrin IX
right: Menaquinol 6
spontaneous: false
EC number: 1.3.5.3
left: menaquinone-8
left: Protoporphyrinogen IX
name: Protoporphyrinogen IX + menaquinone-8 → Menaquinol 6 + Protoporphyrin IX
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reaction982922
type: BiochemicalReaction
participant stoichiometry: Compound/PW C041228/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041220/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: NADH
right: Hydrogen Ion
right: Sirohydrochlorin
spontaneous: false
left: Precorrin 2
left: NAD
name: NAD + Precorrin 2 ↔ 2 Hydrogen Ion + NADH + Sirohydrochlorin
conversion direction: REVERSIBLE

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

4.99.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000163/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000544/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042924/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: Hydrogen Ion
right: ferroheme b
spontaneous: false
EC number: 4.99.1.1
left: Protoporphyrin IX
left: Fe2+
name: Fe2+ + Protoporphyrin IX → 2 Hydrogen Ion + ferroheme b
conversion direction: LEFT_TO_RIGHT

1.3.5.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000863/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000163/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783/Stoichiometry/3.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/3.0
right: Protoporphyrin IX
right: Hydrogen peroxide
spontaneous: false
EC number: 1.3.5.3
left: Oxygen
left: Protoporphyrinogen IX
name: 3 Oxygen + Protoporphyrinogen IX → 3 Hydrogen peroxide + Protoporphyrin IX
conversion direction: LEFT_TO_RIGHT

Periplasmic Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005620

Reference/HMDB HMDB0001149
type: UnificationXref
id: HMDB0001149
db: HMDB

Reference/KEGG Compound C01051
type: UnificationXref
id: C01051
db: KEGG Compound

Reaction982920
type: BiochemicalReaction
participant stoichiometry: Compound/PW C041228/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000544/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041227/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: Siroheme
right: Hydrogen Ion
spontaneous: false
left: Fe2+
left: Sirohydrochlorin
name: Fe2+ + Sirohydrochlorin → 2 Hydrogen Ion + Siroheme
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001261
type: UnificationXref
id: HMDB0001261
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Compound/PW C001451/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coproporphyrinogen I
stoichiometric coefficient: 1.0

Amino acid transport ATP-binding protein
type: Protein
cellular location: Inner Membrane
entity reference: Amino acid transport ATP-binding protein

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Compound/PW C041227/Stoichiometry/1.0
type: Stoichiometry
physical entity: Siroheme
stoichiometric coefficient: 1.0

Tetratricopeptide repeat-containing protein
type: Protein
entity reference: Tetratricopeptide repeat-containing protein

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Thiol disulfide interchange protein DsbD like protein
type: Protein
entity reference: Thiol disulfide interchange protein DsbD like protein

Flagellar filament outer layer protein FlaA
type: Protein
entity reference: Flagellar filament outer layer protein FlaA

5'-Deoxyadenosine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05198
xref: Reference/ChemSpider 388325
xref: Reference/CAS 4754-39-6
xref: Reference/HMDB HMDB0001983
xref: Reference/ChEBI CHEBI 17319
xref: Reference/BioCyc CH33ADO
xref: Reference/PubChem-compound 439182
chemical formula: C10H13N5O3
molecular weight: 251.10184
structure: ChemicalStructure/PW C001329

Protein translocase subunit SecA
type: Protein
entity reference: Protein translocase subunit SecA

Probable transaldolase
type: Protein
entity reference: Probable transaldolase

Coproporphyrinogen I
type: SmallMolecule
entity reference: Coproporphyrinogen I

Outer membrane lipoprotein carrier protein LolA
type: Protein
entity reference: Outer membrane lipoprotein carrier protein LolA

Ferrochelatase
type: Protein
entity reference: Ferrochelatase

Putative coproporphyrinogen III oxidase
type: Protein
entity reference: Putative coproporphyrinogen III oxidase

Coproporphyrinogen I
type: SmallMoleculeReference
xref: Reference/BioCyc COPROPORPHYRINOGEN I
xref: Reference/ChemSpider 389645
xref: Reference/HMDB HMDB0002158
xref: Reference/CAS 31110-56-2
xref: Reference/ChEBI CHEBI 28607
xref: Reference/KEGG Compound C05768
xref: Reference/PubChem-compound 440776
chemical formula: C36H44N4O8
molecular weight: 660.3159
structure: ChemicalStructure/PW C001451

Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000922
type: UnificationXref
id: PW000922
db: PathWhiz

Flavodoxin
type: ProteinReference
xref: Reference/UniProt J9U1W3

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Compound/PW C041220/Stoichiometry/1.0
type: Stoichiometry
physical entity: Precorrin 2
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

1.2.1.70
type: BiochemicalReaction
participant stoichiometry: RNA/8/Stoichiometry/8.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/8.0
participant stoichiometry: Compound/PW C042930/Stoichiometry/8.0
participant stoichiometry: Compound/PW C000146/Stoichiometry/8.0
participant stoichiometry: RNA/7/Stoichiometry/8.0
right: (S)-4-amino-5-oxopentanoate
right: NADP
right: tRNA(Glu)
spontaneous: false
EC number: 1.2.1.70
left: NADPH
left: L-Glutamyl-tRNA(Glu)
name: 8 L-Glutamyl-tRNA(Glu) + 8 NADPH → 8 (S)-4-amino-5-oxopentanoate + 8 NADP + 8 tRNA(Glu)
conversion direction: LEFT_TO_RIGHT

5.4.3.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C042930/Stoichiometry/8.0
participant stoichiometry: Compound/PW C000894/Stoichiometry/8.0
right: 5-Aminolevulinic acid
spontaneous: false
EC number: 5.4.3.8
left: (S)-4-amino-5-oxopentanoate
name: 8 (S)-4-amino-5-oxopentanoate → 8 5-Aminolevulinic acid
conversion direction: LEFT_TO_RIGHT

4.2.1.24
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000166/Stoichiometry/4.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/8.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/4.0
participant stoichiometry: Compound/PW C000894/Stoichiometry/8.0
right: Water
right: Porphobilinogen
right: Hydrogen Ion
spontaneous: false
EC number: 4.2.1.24
left: 5-Aminolevulinic acid
name: 8 5-Aminolevulinic acid → 4 Hydrogen Ion + 4 Porphobilinogen + 8 Water
conversion direction: LEFT_TO_RIGHT

5'-Deoxyadenosine
type: SmallMolecule
entity reference: 5'-Deoxyadenosine

Reference/ChEBI CHEBI 57501
type: UnificationXref
id: CHEBI:57501
db: ChEBI

Reaction982906
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034/Stoichiometry/8.0
participant stoichiometry: RNA/8/Stoichiometry/8.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/8.0
participant stoichiometry: Compound/PW C000032/Stoichiometry/8.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/8.0
participant stoichiometry: Compound/PW C000095/Stoichiometry/8.0
participant stoichiometry: RNA/7/Stoichiometry/8.0
right: Adenosine monophosphate
right: Pyrophosphate
right: L-Glutamyl-tRNA(Glu)
spontaneous: false
left: L-Glutamic acid
left: Hydrogen Ion
left: tRNA(Glu)
left: Adenosine triphosphate
name: 8 Adenosine triphosphate + 8 Hydrogen Ion + 8 L-Glutamic acid + 8 tRNA(Glu) → 8 Adenosine monophosphate + 8 L-Glutamyl-tRNA(Glu) + 8 Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/ChemSpider 995
type: UnificationXref
id: 995
db: ChemSpider

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Reference/PathWhiz PW000919
type: UnificationXref
id: PW000919
db: PathWhiz

Porphyrin Metabolism
type: Pathway
pathway order: PathwaySubPathway/463921
pathway order: PathwaySubPathway/463920
pathway order: PathwayEnzymeReaction/6324370
pathway order: PathwayEnzymeReaction/6324392
pathway order: PathwayEnzymeReaction/6324391
pathway order: PathwayEnzymeReaction/6324390
pathway order: PathwayEnzymeReaction/6324374
pathway order: PathwayEnzymeReaction/6324396
pathway order: PathwayEnzymeReaction/6324373
pathway order: PathwayEnzymeReaction/6324395
pathway order: PathwayEnzymeReaction/6324394
pathway order: PathwayEnzymeReaction/6324393
pathway order: PathwayEnzymeReaction/6324378
pathway order: PathwayEnzymeReaction/6324377
pathway order: PathwayEnzymeReaction/6324376
pathway order: PathwayEnzymeReaction/6324375
pathway order: PathwayEnzymeReaction/6324379
pathway order: PathwaySubPathway/463919
pathway order: PathwaySubPathway/463918
pathway order: PathwayEnzymeReaction/6324381
pathway order: PathwayEnzymeReaction/6324380
pathway order: PathwaySubPathway/463917
pathway order: PathwayEnzymeReaction/6324384
pathway order: PathwayEnzymeReaction/6324383
pathway order: PathwayEnzymeReaction/6324382
pathway order: PathwayEnzymeReaction/6324387
pathway order: PathwayEnzymeReaction/6324369
pathway order: PathwayTransport/6324398
pathway order: PathwayTransport/6324397
pathway component: ReactionCatalysis999752
pathway component: ReactionCatalysis999753
pathway component: ReactionCoupledTransport7120
pathway component: ReactionCatalysis999754
pathway component: ReactionCatalysis999755
pathway component: ReactionCatalysis999756
pathway component: ReactionCatalysis999757
pathway component: ReactionCatalysis999758
pathway component: ReactionCatalysis999759
pathway component: Reaction982925
pathway component: 1.3.5.3
pathway component: Reaction982922
pathway component: 4.99.1.1
pathway component: Reaction982920
pathway component: ReactionCoupledTransportCatalysis7182
pathway component: Reaction3479
pathway component: ReactionCatalysis999750
pathway component: ReactionCatalysis999751
pathway component: ReactionCatalysis999760
pathway component: 1.2.1.70
pathway component: 5.4.3.8
pathway component: 4.2.1.24
pathway component: Reaction982906
pathway component: Transport41013
pathway component: Transport41012
pathway component: TransportCatalysis23767
pathway component: TransportCatalysis23768
pathway component: L-Glutamate Metabolism
pathway component: ReactionCatalysis999741
pathway component: ReactionCatalysis999742
pathway component: ReactionCatalysis999743
pathway component: Sulfur Metabolism
pathway component: ReactionCatalysis999744
pathway component: ReactionCatalysis999745
pathway component: ReactionCatalysis999746
pathway component: Oxidative Phosphorylation
pathway component: ReactionCatalysis999747
pathway component: ReactionCatalysis999748
pathway component: ReactionCatalysis999749
pathway component: Reaction982918
pathway component: Reaction982919
pathway component: Reaction982914
pathway component: 2.5.1.-
pathway component: 1.11.1.6
pathway component: 2.1.1.107
pathway component: 2.5.1.61
pathway component: 4.2.1.75
pathway component: 4.1.1.37
pathway component: 1.3.3.3

Compound/PW C042930/Stoichiometry/8.0
type: Stoichiometry
physical entity: (S)-4-amino-5-oxopentanoate
stoichiometric coefficient: 8.0

Reference/UniProt J9U9I0
type: UnificationXref
id: J9U9I0
db: UniProt

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Reference/HMDB HMDB0001162
type: UnificationXref
id: HMDB0001162
db: HMDB

Catalase
type: ProteinReference
xref: Reference/UniProt J9UVF7

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/CAS 1867-62-5
type: UnificationXref
id: 1867-62-5
db: CAS

Reference/PathWhiz PW449621
type: UnificationXref
id: PW449621
db: PathWhiz

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/CAS 15438-31-0
type: UnificationXref
id: 15438-31-0
db: CAS

Reference/UniProt J9UHH0
type: UnificationXref
id: J9UHH0
db: UniProt

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/HMDB HMDB0041827
type: UnificationXref
id: HMDB0041827
db: HMDB

Reference/CAS 31110-56-2
type: UnificationXref
id: 31110-56-2
db: CAS

Reference/ChemSpider 25394
type: UnificationXref
id: 25394
db: ChemSpider

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Reference/KEGG Compound C01079
type: UnificationXref
id: C01079
db: KEGG Compound

Reaction982918
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042627/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041684/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Precorrin-2
spontaneous: false
left: Precorrin-1
left: S-Adenosylmethionine
name: Precorrin-1 + S-Adenosylmethionine → Precorrin-2 + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

L-Glutamic acid
type: SmallMolecule
cellular location: Inner Membrane
entity reference: L-Glutamic acid

Reaction982919
type: BiochemicalReaction
participant stoichiometry: Compound/PW C041228/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042627/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADH
right: Hydrogen Ion
right: Sirohydrochlorin
spontaneous: false
left: NAD
left: Precorrin-2
name: NAD + Precorrin-2 → Hydrogen Ion + NADH + Sirohydrochlorin
conversion direction: LEFT_TO_RIGHT

Reaction982914
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000863/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000974/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001329/Stoichiometry/1.0
right: Carbon dioxide
right: Protoporphyrinogen IX
right: 5'-Deoxyadenosine
right: L-Methionine
spontaneous: false
left: Coproporphyrinogen III
left: S-Adenosylmethionine
name: Coproporphyrinogen III + S-Adenosylmethionine → 5'-Deoxyadenosine + Carbon dioxide + L-Methionine + Protoporphyrinogen IX
conversion direction: LEFT_TO_RIGHT

2.5.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042924/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000768/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000900/Stoichiometry/1.0
right: Pyrophosphate
right: Heme O
spontaneous: false
EC number: 2.5.1.-
left: Water
left: Farnesyl pyrophosphate
left: ferroheme b
name: Farnesyl pyrophosphate + Water + ferroheme b → Heme O + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

1.11.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C041459/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042924/Stoichiometry/1.0
right: Heme D
spontaneous: false
EC number: 1.11.1.6
left: Hydrogen peroxide
left: ferroheme b
name: Hydrogen peroxide + ferroheme b → Heme D
conversion direction: LEFT_TO_RIGHT

2.1.1.107
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000854/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041684/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Hydrogen Ion
right: Precorrin-1
spontaneous: false
EC number: 2.1.1.107
left: S-Adenosylmethionine
left: Uroporphyrinogen III
name: S-Adenosylmethionine + Uroporphyrinogen III → Hydrogen Ion + Precorrin-1 + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

2.5.1.61
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000887/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000166/Stoichiometry/4.0
participant stoichiometry: Compound/PW C022608/Stoichiometry/4.0
right: Ammonium
right: Hydroxymethylbilane
spontaneous: false
EC number: 2.5.1.61
left: Water
left: Porphobilinogen
name: 4 Porphobilinogen + Water → 4 Ammonium + Hydroxymethylbilane
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc 5-AMINO-LEVULINATE
type: UnificationXref
id: 5-AMINO-LEVULINATE
db: BioCyc

4.2.1.75
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000887/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000854/Stoichiometry/1.0
right: Water
right: Uroporphyrinogen III
spontaneous: false
EC number: 4.2.1.75
left: Hydroxymethylbilane
name: Hydroxymethylbilane → Uroporphyrinogen III + Water
conversion direction: LEFT_TO_RIGHT

4.1.1.37
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000854/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000974/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/4.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/4.0
right: Carbon dioxide
right: Coproporphyrinogen III
spontaneous: false
EC number: 4.1.1.37
left: Hydrogen Ion
left: Uroporphyrinogen III
name: 4 Hydrogen Ion + Uroporphyrinogen III → 4 Carbon dioxide + Coproporphyrinogen III
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C03263
type: UnificationXref
id: C03263
db: KEGG Compound

1.3.3.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000863/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000974/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: Water
right: Carbon dioxide
right: Protoporphyrinogen IX
spontaneous: false
EC number: 1.3.3.3
left: Hydrogen Ion
left: Oxygen
left: Coproporphyrinogen III
name: Coproporphyrinogen III + 2 Hydrogen Ion + Oxygen → 2 Carbon dioxide + Protoporphyrinogen IX + 2 Water
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 10469486
type: UnificationXref
id: 10469486
db: ChemSpider

Adenosine diphosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Adenosine diphosphate

Reference/BioCyc COPROPORPHYRINOGEN III
type: UnificationXref
id: COPROPORPHYRINOGEN_III
db: BioCyc

Compound/PW C001104 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

(S)-4-amino-5-oxopentanoate
type: SmallMolecule
entity reference: (S)-4-amino-5-oxopentanoate

ReactionCatalysis999752
type: Catalysis
controller: Outer membrane lipoprotein carrier protein LolA
controlled: 2.1.1.107
control type: ACTIVATION

ReactionCatalysis999753
type: Catalysis
controller: Outer membrane lipoprotein carrier protein LolA
controlled: Reaction982918
control type: ACTIVATION

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

ReactionCatalysis999754
type: Catalysis
controller: Outer membrane lipoprotein carrier protein LolA
controlled: Reaction982919
control type: ACTIVATION

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

ReactionCatalysis999755
type: Catalysis
controller: Outer membrane lipoprotein carrier protein LolA
controlled: Reaction982920
control type: ACTIVATION

ReactionCatalysis999756
type: Catalysis
controller: protoporphyrinogen oxidase
controlled: 1.3.5.3
control type: ACTIVATION

ReactionCatalysis999757
type: Catalysis
controller: Outer membrane lipoprotein carrier protein LolA
controlled: Reaction982922
control type: ACTIVATION

ReactionCatalysis999758
type: Catalysis
controller: Ferrochelatase
controlled: 4.99.1.1
control type: ACTIVATION

Na/H dicarboxylate symporters putative
type: Protein
entity reference: Na/H dicarboxylate symporters putative

ReactionCatalysis999759
type: Catalysis
controller: protoporphyrinogen oxidase
controlled: 1.3.5.3
control type: ACTIVATION

Reference/ChEBI CHEBI 50602
type: UnificationXref
id: CHEBI:50602
db: ChEBI

NADH
type: SmallMolecule
entity reference: NADH

Reference/HMDB HMDB0001983
type: UnificationXref
id: HMDB0001983
db: HMDB

Reference/ChemSpider 134
type: UnificationXref
id: 134
db: ChemSpider

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

protoporphyrinogen oxidase
type: Complex
component stoichiometry: Protein/44718/Stoichiometry/4.0
component: Flavodoxin

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

ReactionCatalysis999750
type: Catalysis
controller: Sugar ABC transporter inner membrane protein
controlled: 2.5.1.-
control type: ACTIVATION

Reference/PubChem-compound 53356674
type: UnificationXref
id: 53356674
db: PubChem-compound

ReactionCatalysis999751
type: Catalysis
controller: catalase II
controlled: 1.11.1.6
control type: ACTIVATION

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Compound/PW C001034 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

ferroheme b
type: SmallMolecule
entity reference: ferroheme b
name: SubPathwayInput

Protoporphyrin IX
type: SmallMolecule
entity reference: Protoporphyrin IX

coproporphyrinogen III oxidase
type: Complex
component stoichiometry: Protein/75704/Stoichiometry/2.0
component: Thiol disulfide interchange protein DsbD like protein

Uroporphyrinogen I
type: SmallMolecule
entity reference: Uroporphyrinogen I

Polar amino acid uptake ABC transporter amino acid-binding protein
type: Protein
cellular location: Inner Membrane
entity reference: Polar amino acid uptake ABC transporter amino acid-binding protein

Reference/ChemSpider 393270
type: UnificationXref
id: 393270
db: ChemSpider

Uroporphyrinogen I
type: SmallMoleculeReference
xref: Reference/ChemSpider 389644
xref: Reference/ChEBI CHEBI 28766
xref: Reference/BioCyc UROPORPHYRINOGEN-III
xref: Reference/KEGG Compound C05766
xref: Reference/CAS 1867-62-5
xref: Reference/HMDB HMDB0002211
xref: Reference/PubChem-compound 440775
chemical formula: C40H44N4O16
molecular weight: 836.2752
structure: ChemicalStructure/PW C001496

Porphobilinogen
type: SmallMolecule
entity reference: Porphobilinogen

Reference/KEGG Compound C02191
type: UnificationXref
id: C02191
db: KEGG Compound

Reference/ChemSpider 3571849
type: UnificationXref
id: 3571849
db: ChemSpider

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Compound/PW C000032/Stoichiometry/8.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 8.0

glutamate-1-semialdehyde aminotransferase
type: Complex
component stoichiometry: Protein/36895/Stoichiometry/2.0
component: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Porphobilinogen
type: SmallMoleculeReference
xref: Reference/ChemSpider 995
xref: Reference/KEGG Compound C00931
xref: Reference/HMDB HMDB0000245
xref: Reference/CAS 487-90-1
xref: Reference/ChEBI CHEBI 17381
xref: Reference/BioCyc PORPHOBILINOGEN
xref: Reference/PubChem-compound 1021
chemical formula: C10H14N2O4
molecular weight: 226.09535
structure: ChemicalStructure/PW C000166

glutamyl-tRNA reductase
type: Complex
component stoichiometry: Protein/75700/Stoichiometry/2.0
component: Tetratricopeptide repeat-containing protein

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

porphobilinogen synthase
type: Complex
component stoichiometry: Protein/75701/Stoichiometry/8.0
component: Probable transaldolase

Protoporphyrin IX
type: SmallMoleculeReference
xref: Reference/CAS 553-12-8
xref: Reference/KEGG Compound C02191
xref: Reference/BioCyc PROTOPORPHYRIN IX
xref: Reference/ChemSpider 10469486
xref: Reference/ChEBI CHEBI 15430
xref: Reference/HMDB HMDB0000241
chemical formula: C34H34N4O4
molecular weight: 562.258
structure: ChemicalStructure/PW C000163

ReactionCatalysis999760
type: Catalysis
controller: Flagellar filament outer layer protein FlaA
controlled: Reaction982925
control type: ACTIVATION

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

ferroheme b
type: SmallMoleculeReference
xref: Reference/PubChem-compound 53356674
chemical formula: C34H30FeN4O4
molecular weight: 614.1638
structure: ChemicalStructure/PW C042924

Compound/PW C000146/Stoichiometry/8.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 8.0

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

tRNA(Glu)
type: Rna
entity reference: tRNA(Glu)

ChemicalStructure/PW C000544
type: ChemicalStructure
structure format: SMILES
structure data: [Fe++]

L-Glutamyl-tRNA(Glu)
type: Rna
entity reference: L-Glutamyl-tRNA(Glu)

Reference/UniProt J9UXB3
type: UnificationXref
id: J9UXB3
db: UniProt

ChemicalStructure/PW C000548
type: ChemicalStructure
structure format: SMILES
structure data: CSCC[C@H](N)C(O)=O

Compound/PW C040034/Stoichiometry/8.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 8.0

Sodium/glutamate symporter
type: Protein
entity reference: Sodium/glutamate symporter

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Transport41013
type: Transport
participant stoichiometry: Compound/PW C000095 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
right: L-Glutamic acid
spontaneous: false
left: Sodium
left: L-Glutamic acid
name: L-Glutamic acid (→), Sodium (→) Transport: Brachyspira pilosicoli B2904, Periplasmic Space to Brachyspira pilosicoli B2904, Cytosol
conversion direction: LEFT_TO_RIGHT

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Transport41012
type: Transport
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: L-Glutamic acid
spontaneous: false
left: Hydrogen Ion
left: L-Glutamic acid
name: Hydrogen Ion (→), L-Glutamic acid (→) Transport: Brachyspira pilosicoli B2904, Periplasmic Space to Brachyspira pilosicoli B2904, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc Ferric-Hydroxamate-Complexes
type: UnificationXref
id: Ferric-Hydroxamate-Complexes
db: BioCyc

Amino acid transport ATP-binding protein
type: ProteinReference
xref: Reference/UniProt J9TQ44
organism: Brachyspira pilosicoli B2904

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

ReactionCatalysis999741
type: Catalysis
controller: Unknown
controlled: Reaction982906
control type: ACTIVATION

Reference/PubChem-compound 137
type: UnificationXref
id: 137
db: PubChem-compound

ReactionCatalysis999742
type: Catalysis
controller: glutamyl-tRNA reductase
controlled: 1.2.1.70
control type: ACTIVATION

ReactionCatalysis999743
type: Catalysis
controller: glutamate-1-semialdehyde aminotransferase
controlled: 5.4.3.8
control type: ACTIVATION

ReactionCatalysis999744
type: Catalysis
controller: porphobilinogen synthase
controlled: 4.2.1.24
control type: ACTIVATION

ReactionCatalysis999745
type: Catalysis
controller: Protein translocase subunit SecA
controlled: 2.5.1.61
control type: ACTIVATION

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

(S)-4-amino-5-oxopentanoate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25244684
xref: Reference/ChEBI CHEBI 57501
chemical formula: C5H9NO3
molecular weight: 131.05824
structure: ChemicalStructure/PW C042930

ReactionCatalysis999746
type: Catalysis
controller: Rhodanese domain protein
controlled: 4.2.1.75
control type: ACTIVATION

ReactionCatalysis999747
type: Catalysis
controller: Flagellar filament outer layer protein FlaA
controlled: 4.1.1.37
control type: ACTIVATION

ReactionCatalysis999748
type: Catalysis
controller: coproporphyrinogen III oxidase
controlled: 1.3.3.3
control type: ACTIVATION

ReactionCatalysis999749
type: Catalysis
controller: Putative coproporphyrinogen III oxidase
controlled: Reaction982914
control type: ACTIVATION

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

NADPH
type: SmallMolecule
entity reference: NADPH

Reference/UniProt J9U0U4
type: UnificationXref
id: J9U0U4
db: UniProt

Reference/PubChem-compound 1021
type: UnificationXref
id: 1021
db: PubChem-compound

Reference/UniProt J9U1W3
type: UnificationXref
id: J9U1W3
db: UniProt

Compound/PW C000894/Stoichiometry/8.0
type: Stoichiometry
physical entity: 5-Aminolevulinic acid
stoichiometric coefficient: 8.0

Reference/GENE ONTOLOGY GO 0070258
type: UnificationXref
id: GO:0070258
db: GENE ONTOLOGY

Reference/CAS 137397-56-9
type: UnificationXref
id: 137397-56-9
db: CAS

Reference/CAS 7412-77-3
type: UnificationXref
id: 7412-77-3
db: CAS

glutamate / aspartate ABC transporter
type: Complex
cellular location: Inner Membrane
component: Amino acid transport ATP-binding protein
component: Polar amino acid uptake ABC transporter amino acid-binding protein
component: Amino acid transport system permease

Reference/UniProt J9UAV6
type: UnificationXref
id: J9UAV6
db: UniProt

NADP
type: SmallMolecule
entity reference: NADP

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reference/PubChem-compound 196427
type: UnificationXref
id: 196427
db: PubChem-compound

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Compound/PW C000143/Stoichiometry/8.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 8.0

Reference/PubChem-compound 5376507
type: UnificationXref
id: 5376507
db: PubChem-compound

Reference/BioCyc CH33ADO
type: UnificationXref
id: CH33ADO
db: BioCyc

Compound/PW C042924/Stoichiometry/1.0
type: Stoichiometry
physical entity: ferroheme b
stoichiometric coefficient: 1.0

Reference/PubChem-compound 27284
type: UnificationXref
id: 27284
db: PubChem-compound

Compound/PW C000170/Stoichiometry/8.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 8.0

Reference/ChEBI CHEBI 58893
type: UnificationXref
id: CHEBI:58893
db: ChEBI

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/ChemSpider 218
type: UnificationXref
id: 218
db: ChemSpider

Reference/PubChem-compound 321
type: UnificationXref
id: 321
db: PubChem-compound

catalase II
type: Complex
component stoichiometry: Protein/33940/Stoichiometry/4.0
component: Catalase

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid
name: SubPathwayOutput

Reference/ChemSpider 108741
type: UnificationXref
id: 108741
db: ChemSpider

Reference/HMDB HMDB0000696
type: UnificationXref
id: HMDB0000696
db: HMDB

Reference/ChEBI CHEBI 24480
type: UnificationXref
id: CHEBI:24480
db: ChEBI

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Oxygen
type: SmallMolecule
entity reference: Oxygen

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Hydrogen Ion
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Hydrogen Ion

Reference/HMDB HMDB0000692
type: UnificationXref
id: HMDB0000692
db: HMDB

Reference/CAS 4754-39-6
type: UnificationXref
id: 4754-39-6
db: CAS

Sugar ABC transporter inner membrane protein
type: Protein
entity reference: Sugar ABC transporter inner membrane protein

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

SubPathwayInteraction463918
type: Interaction
name: SubPathway463918Reaction
name: SubPathwayReaction
participant: Siroheme

SubPathwayInteraction463917
type: Interaction
name: SubPathwayReaction
name: SubPathway463917Reaction
participant: L-Glutamic acid

SubPathwayInteraction463919
type: Interaction
name: SubPathway463919Reaction
name: SubPathwayReaction
participant: Heme D

Reference/UniProt J9USX0
type: UnificationXref
id: J9USX0
db: UniProt

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Rhodanese domain protein
type: Protein
entity reference: Rhodanese domain protein

Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070258

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Compound/PW C041459/Stoichiometry/1.0
type: Stoichiometry
physical entity: Heme D
stoichiometric coefficient: 1.0

Brachyspira pilosicoli B2904
type: BioSource
xref: Reference/TAXONOMY 1133568

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Protein/75704/Stoichiometry/2.0
type: Stoichiometry
physical entity: Thiol disulfide interchange protein DsbD like protein
stoichiometric coefficient: 2.0

Reference/PubChem-compound 6441040
type: UnificationXref
id: 6441040
db: PubChem-compound

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Compound/PW C000768/Stoichiometry/1.0
type: Stoichiometry
physical entity: Farnesyl pyrophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 44027
type: UnificationXref
id: CHEBI:44027
db: ChEBI

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/KEGG Compound C00931
type: UnificationXref
id: C00931
db: KEGG Compound

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Reference/ChEBI CHEBI 28938
type: UnificationXref
id: CHEBI:28938
db: ChEBI

Tetratricopeptide repeat-containing protein
type: ProteinReference
xref: Reference/UniProt J9USE6

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Probable transaldolase
type: ProteinReference
xref: Reference/UniProt J9UAV6

Protein translocase subunit SecA
type: ProteinReference
xref: Reference/UniProt J9UHH0

Flagellar filament outer layer protein FlaA
type: ProteinReference
xref: Reference/UniProt J9UX66

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005620
type: UnificationXref
id: GO:0005620
db: GENE ONTOLOGY

Thiol disulfide interchange protein DsbD like protein
type: ProteinReference
xref: Reference/UniProt J9USL5

SubPathwayInteraction463921
type: Interaction
name: SubPathway463921Reaction
name: SubPathwayReaction
participant: Heme O

Putative coproporphyrinogen III oxidase
type: ProteinReference
xref: Reference/UniProt J9UDJ2

Compound/PW C000095 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

SubPathwayInteraction463920
type: Interaction
name: SubPathwayReaction
name: SubPathway463920Reaction
participant: ferroheme b

RNA/7/Stoichiometry/8.0
type: Stoichiometry
physical entity: L-Glutamyl-tRNA(Glu)
stoichiometric coefficient: 8.0

Ferrochelatase
type: ProteinReference
xref: Reference/UniProt J9UF74

Outer membrane lipoprotein carrier protein LolA
type: ProteinReference
xref: Reference/UniProt J9UBG5

Reference/UniProt J9TQ44
type: UnificationXref
id: J9TQ44
db: UniProt

Protein/44718/Stoichiometry/4.0
type: Stoichiometry
physical entity: Flavodoxin
stoichiometric coefficient: 4.0

Compound/PW C022608/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ammonium
stoichiometric coefficient: 4.0

ChemicalStructure/PW C001329
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001451
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000245
type: UnificationXref
id: HMDB0000245
db: HMDB

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/BioCyc PORPHOBILINOGEN
type: UnificationXref
id: PORPHOBILINOGEN
db: BioCyc

Reference/HMDB HMDB0000241
type: UnificationXref
id: HMDB0000241
db: HMDB

ReactionCoupledTransport7120
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Inner Membrane/Stoichiometry/1.0
right: Phosphate
right: L-Glutamic acid
right: Adenosine diphosphate
right: Hydrogen Ion
spontaneous: false
left: Water
left: Adenosine triphosphate
left: L-Glutamic acid
name: Adenosine triphosphate + L-Glutamic acid + Water → Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Menaquinol 6
type: SmallMolecule
entity reference: Menaquinol 6

menaquinone-8
type: SmallMolecule
entity reference: menaquinone-8

Precorrin-1
type: SmallMolecule
entity reference: Precorrin-1

Adenosine triphosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Adenosine triphosphate

Precorrin-2
type: SmallMoleculeReference
chemical formula: C42H48N4O16
molecular weight: 864.3065
structure: ChemicalStructure/PW C042627

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Compound/PW C001316/Stoichiometry/2.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 28766
type: UnificationXref
id: CHEBI:28766
db: ChEBI

Reference/ChEBI CHEBI 15439
type: UnificationXref
id: CHEBI:15439
db: ChEBI

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Phosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Phosphate

Reference/UniProt J9UUX7
type: UnificationXref
id: J9UUX7
db: UniProt

Flavodoxin
type: Protein
entity reference: Flavodoxin

ChemicalStructure/PW C000854
type: ChemicalStructure
structure format: SMILES

Compound/PW C000414 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000974
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Catalase
type: Protein
entity reference: Catalase

Reference/PubChem-compound 440776
type: UnificationXref
id: 440776
db: PubChem-compound

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

Reference/PubChem-compound 440775
type: UnificationXref
id: 440775
db: PubChem-compound

Reference/PubChem-compound 439303
type: UnificationXref
id: 439303
db: PubChem-compound

Compound/PW C042627/Stoichiometry/1.0
type: Stoichiometry
physical entity: Precorrin-2
stoichiometric coefficient: 1.0

Reference/CAS 14798-03-9
type: UnificationXref
id: 14798-03-9
db: CAS

Reference/PubChem-compound 5280516
type: UnificationXref
id: 5280516
db: PubChem-compound

Water
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Water

RNA/8/Stoichiometry/8.0
type: Stoichiometry
physical entity: tRNA(Glu)
stoichiometric coefficient: 8.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Siroheme
type: SmallMolecule
entity reference: Siroheme
name: SubPathwayInput

Precorrin 2
type: SmallMolecule
entity reference: Precorrin 2

Compound/PW C001783/Stoichiometry/3.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 3.0

Reference/CAS 1976-85-8
type: UnificationXref
id: 1976-85-8
db: CAS

Reference/CAS 106-60-5
type: UnificationXref
id: 106-60-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Sirohydrochlorin
type: SmallMolecule
entity reference: Sirohydrochlorin

Reference/KEGG Compound C05198
type: UnificationXref
id: C05198
db: KEGG Compound

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Compound/PW C040034/Stoichiometry/4.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 4.0

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Menaquinol 6
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6441040
xref: Reference/ChEBI CHEBI 18151
chemical formula: C41H58O2
molecular weight: 582.44366
structure: ChemicalStructure/PW C041682

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

menaquinone-8
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5376507
xref: Reference/ChEBI CHEBI 44027
chemical formula: C51H72O2
molecular weight: 716.5532
structure: ChemicalStructure/PW C041683

ChemicalStructure/PW C022608
type: ChemicalStructure
structure format: SMILES
structure data: [NH4+]

Precorrin-1
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58893
xref: Reference/PubChem-compound 25245954
chemical formula: C41H46N4O16
molecular weight: 850.2909
structure: ChemicalStructure/PW C041684

Compound/PW C000887/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydroxymethylbilane
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16643
type: UnificationXref
id: CHEBI:16643
db: ChEBI

Reference/ChEBI CHEBI 16645
type: UnificationXref
id: CHEBI:16645
db: ChEBI

Reference/ChEBI CHEBI 15435
type: UnificationXref
id: CHEBI:15435
db: ChEBI

Reference/ChEBI CHEBI 15437
type: UnificationXref
id: CHEBI:15437
db: ChEBI

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/CAS 487-90-1
type: UnificationXref
id: 487-90-1
db: CAS

Reference/BioCyc HEME O
type: UnificationXref
id: HEME_O
db: BioCyc

Reference/ChEBI CHEBI 28607
type: UnificationXref
id: CHEBI:28607
db: ChEBI

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Heme D
type: SmallMolecule
entity reference: Heme D
name: SubPathwayInput

Reference/ChEBI CHEBI 15430
type: UnificationXref
id: CHEBI:15430
db: ChEBI

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/UniProt J9UF74
type: UnificationXref
id: J9UF74
db: UniProt

Reference/HMDB HMDB0000961
type: UnificationXref
id: HMDB0000961
db: HMDB

Compound/PW C000548/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 1.0

Protein/75700/Stoichiometry/2.0
type: Stoichiometry
physical entity: Tetratricopeptide repeat-containing protein
stoichiometric coefficient: 2.0

Compound/PW C041683/Stoichiometry/1.0
type: Stoichiometry
physical entity: menaquinone-8
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000789
type: UnificationXref
id: PW000789
db: PathWhiz

Heme O
type: SmallMoleculeReference
xref: Reference/CAS 137397-56-9
xref: Reference/ChEBI CHEBI 24480
xref: Reference/KEGG Compound C15672
xref: Reference/BioCyc HEME O
xref: Reference/ChemSpider 3571849
xref: Reference/HMDB HMDB0001162
chemical formula: C49H58FeN4O5
molecular weight: 838.3757
structure: ChemicalStructure/PW C000900

Reference/ChEBI CHEBI 17549
type: UnificationXref
id: CHEBI:17549
db: ChEBI

ChemicalStructure/PW C000887
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 1179
type: UnificationXref
id: 1179
db: PubChem-compound

Compound/PW C000095/Stoichiometry/8.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 8.0

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

ChemicalStructure/PW C000768
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000894
type: ChemicalStructure
structure format: SMILES
structure data: NCC(=O)CCC(O)=O

Compound/PW C001065/Stoichiometry/3.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 3.0

Compound/PW C000095 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Compound/PW C001316/Stoichiometry/4.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/PubChem-compound 3582
type: UnificationXref
id: 3582
db: PubChem-compound

Sodium
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Sodium

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 17319
type: UnificationXref
id: CHEBI:17319
db: ChEBI

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

S-Adenosylmethionine
type: SmallMolecule
entity reference: S-Adenosylmethionine

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/BioCyc PROTOPORPHYRIN IX
type: UnificationXref
id: PROTOPORPHYRIN_IX
db: BioCyc

Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
type: ProteinReference
xref: Reference/UniProt J9U0U4

Reference/ChEBI CHEBI 17407
type: UnificationXref
id: CHEBI:17407
db: ChEBI

Reference/PubChem-compound 16741146
type: UnificationXref
id: 16741146
db: PubChem-compound

ChemicalStructure/PW C000863
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

Compound/PW C000749/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C14818
type: UnificationXref
id: C14818
db: KEGG Compound

tRNA(Glu)
type: RnaReference
xref: Reference/ChEBI CHEBI 29175

L-Glutamyl-tRNA(Glu)
type: RnaReference
xref: Reference/ChEBI CHEBI 29157

Rhodanese domain protein
type: ProteinReference
xref: Reference/UniProt J9USX0

Compound/PW C041684/Stoichiometry/1.0
type: Stoichiometry
physical entity: Precorrin-1
stoichiometric coefficient: 1.0

Protein/36895/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
stoichiometric coefficient: 2.0

Reference/UniProt J9USL5
type: UnificationXref
id: J9USL5
db: UniProt

Compound/PW C040034/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Unknown
type: Protein
entity reference: Unknown

Hydrogen Ion
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Hydrogen Ion

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Heme O
type: SmallMolecule
entity reference: Heme O
name: SubPathwayInput

Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/CAS 2624-63-7
type: UnificationXref
id: 2624-63-7
db: CAS

Precorrin-2
type: SmallMolecule
entity reference: Precorrin-2

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Compound/PW C001420/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/UniProt J9UX66
type: UnificationXref
id: J9UX66
db: UniProt