SubPathwayInteraction471174
type: Interaction
name: SubPathway471174Reaction
name: SubPathwayReaction
participant: an (R)-3-hydroxydecanoyl-[acp]

Reference/UniProt C5ZVC8
type: UnificationXref
id: C5ZVC8
db: UniProt

SubPathwayInteraction471172
type: Interaction
name: SubPathway471172Reaction
name: SubPathwayReaction
participant: Acetyl-CoA

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

SubPathwayInteraction471173
type: Interaction
name: SubPathwayReaction
name: SubPathway471173Reaction
participant: cis-Δ5-dodecenoyl-[acp]

KASI
type: Complex
component stoichiometry: Protein/34755/Stoichiometry/2.0
component: 3-oxoacyl-[acyl-carrier-protein] synthase 2

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

enoyl-[acyl-carrier-protein] reductase(NAD)
type: Complex
component stoichiometry: Protein/34417/Stoichiometry/4.0
component: Enoyl-[acyl-carrier-protein] reductase [NADH]

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Protein/Generic203 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: (3R)-3-Hydroxyacyl-[acyl-carrier protein]
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
entity reference: NADH

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Helicobacter canadensis MIT 98-5491
type: BioSource
xref: Reference/TAXONOMY 537970

Reference/SMPDB SMP0438805
type: UnificationXref
id: SMP0438805
db: SMPDB

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Beta-ketoacyl-[acyl-carrier-protein] synthase III
type: ProteinReference
xref: Reference/UniProt C5ZV20

cis-Δ5-dodecenoyl-[acp]
type: Protein
cellular location: Cytosol
entity reference: cis-Δ5-dodecenoyl-[acp]
name: SubPathwayInput

Acetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-CoA
name: SubPathwayOutput

Reference/UniProt C5ZVC6
type: UnificationXref
id: C5ZVC6
db: UniProt

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Enoyl-[acyl-carrier-protein] reductase [NADH]
type: ProteinReference
xref: Reference/UniProt C5ZYR3

3-oxoacyl-[acyl-carrier-protein] synthase 2
type: Protein
entity reference: 3-oxoacyl-[acyl-carrier-protein] synthase 2

3-hydroxy-acyl-[acyl-carrier-protein] dehydratase
type: Complex
component stoichiometry: Protein/29190/Stoichiometry/6.0
component: Unknown

Unknown
type: ProteinReference

Protein/34755 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: 3-oxoacyl-[acyl-carrier-protein] synthase 2
stoichiometric coefficient: 2.0

(3R)-3-Hydroxyacyl-[acyl-carrier protein]
type: Protein
cellular location: Cytosol
entity reference: (3R)-3-Hydroxyacyl-[acyl-carrier protein]

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

NAD
type: SmallMolecule
entity reference: NAD

Reference/UniProt C5ZV20
type: UnificationXref
id: C5ZV20
db: UniProt

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

(3R)-3-Hydroxyacyl-[acyl-carrier protein]
type: ProteinReference
xref: Reference/KEGG Compound C01271

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

trans-2-enoyl-[acyl-carrier protein]
type: ProteinReference

Reference/KEGG Compound C00685
type: UnificationXref
id: C00685
db: KEGG Compound

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC(O)=O

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Protein/Generic195/Stoichiometry/1.0
type: Stoichiometry
physical entity: trans-Δ3-cis-Δ5-dodecenoyl-[acp]
stoichiometric coefficient: 1.0

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Compound/Generic84/Stoichiometry/1.0
type: Stoichiometry
physical entity: a malonyl-[acp]
stoichiometric coefficient: 1.0

KASII
type: Complex
component stoichiometry: Protein/29190/Stoichiometry/2.0
component: Unknown

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

3-hydroxydecanoyl-[acp] dehydrase
type: Complex
component stoichiometry: Protein/45926/Stoichiometry/2.0
component: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

an acetyl-[acp]
type: Protein
entity reference: an acetyl-[acp]

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

acetoacetyl-[acp]
type: Protein
cellular location: Cytosol
entity reference: acetoacetyl-[acp]

cis-Δ3-decenoyl-ACP
type: Protein
entity reference: cis-Δ3-decenoyl-ACP

Protein/29190/Stoichiometry/6.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 6.0

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Protein/Generic135/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Oxoacyl-[acyl-carrier protein]
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

3-oxoacyl-[acyl-carrier-protein] reductase
type: ProteinReference
xref: Reference/UniProt C5ZVC8
organism: Helicobacter canadensis MIT 98-5491

3-oxoacyl-[acyl-carrier-protein] synthase 2
type: Protein
cellular location: Cytosol
entity reference: 3-oxoacyl-[acyl-carrier-protein] synthase 2

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/KEGG Compound C00229
type: UnificationXref
id: C00229
db: KEGG Compound

Enoyl-[acyl-carrier-protein] reductase [NADH]
type: Protein
entity reference: Enoyl-[acyl-carrier-protein] reductase [NADH]

KASI
type: Complex
component stoichiometry: Protein/34755 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: 3-oxoacyl-[acyl-carrier-protein] synthase 2

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

NADPH
type: SmallMolecule
entity reference: NADPH

Protein/Generic170/Stoichiometry/1.0
type: Stoichiometry
physical entity: cis-Δ5-dodecenoyl-[acp]
stoichiometric coefficient: 1.0

trans-Δ3-cis-Δ5-dodecenoyl-[acp]
type: Protein
entity reference: trans-Δ3-cis-Δ5-dodecenoyl-[acp]

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

NADP
type: SmallMolecule
entity reference: NADP

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Protein/Generic185/Stoichiometry/1.0
type: Stoichiometry
physical entity: cis-Δ3-decenoyl-ACP
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

trans-2-enoyl-[acyl-carrier protein]
type: Protein
entity reference: trans-2-enoyl-[acyl-carrier protein]

(3R)-3-Hydroxyacyl-[acyl-carrier protein]
type: Protein
entity reference: (3R)-3-Hydroxyacyl-[acyl-carrier protein]

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

a (3R)-hydroxy cis Δ5-dodecenoyl-[acp]
type: SmallMolecule
entity reference: a (3R)-hydroxy cis Δ5-dodecenoyl-[acp]

Reference/PathWhiz PW000785
type: UnificationXref
id: PW000785
db: PathWhiz

ReactionCatalysis1035118
type: Catalysis
controller: KASII
controlled: Reaction1016369
control type: ACTIVATION

ReactionCatalysis1035119
type: Catalysis
controller: Unknown
controlled: 4.2.1.59
control type: ACTIVATION

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

ReactionCatalysis1035117
type: Catalysis
controller: KASI
controlled: Reaction1016369
control type: ACTIVATION

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

ReactionCatalysis1035121
type: Catalysis
controller: enoyl-[acyl-carrier-protein] reductase(NAD)
controlled: 1.3.1.9
control type: ACTIVATION

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reaction1016378
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/Generic183 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic84 Cytosol/Stoichiometry/1.0
right: an acetyl-[acp]
right: Carbon dioxide
spontaneous: false
left: Hydrogen Ion
left: a malonyl-[acp]
name: Hydrogen Ion + a malonyl-[acp] → Carbon dioxide + an acetyl-[acp]
conversion direction: LEFT_TO_RIGHT

an (R)-3-hydroxydecanoyl-[acp]
type: Protein
cellular location: Cytosol
entity reference: an (R)-3-hydroxydecanoyl-[acp]
name: SubPathwayInput

ReactionCatalysis1035122
type: Catalysis
controller: KASI
controlled: 2.3.1.41
control type: ACTIVATION

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Compound/PW C000463/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Reaction1016379
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/Generic183 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic86 Cytosol/Stoichiometry/1.0
right: an acetyl-[acp]
right: Coenzyme A
spontaneous: false
left: a holo-[acyl-carrier protein]
left: Acetyl-CoA
name: Acetyl-CoA + a holo-[acyl-carrier protein] → Coenzyme A + an acetyl-[acp]
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

ReactionCatalysis1035125
type: Catalysis
controller: 3-hydroxy-acyl-[acyl-carrier-protein] dehydratase
controlled: 4.2.1.59
control type: ACTIVATION

ReactionCatalysis1035126
type: Catalysis
controller: 3-hydroxydecanoyl-[acp] dehydrase
controlled: 4.2.1.59
control type: ACTIVATION

ReactionCatalysis1035123
type: Catalysis
controller: KASII
controlled: 2.3.1.41
control type: ACTIVATION

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ReactionCatalysis1035124
type: Catalysis
controller: 3-hydroxydecanoyl-[acp] dehydrase
controlled: 4.2.1.59
control type: ACTIVATION

4.2.1.59
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Protein/Generic203/Stoichiometry/1.0
participant stoichiometry: Protein/Generic204/Stoichiometry/1.0
right: Water
right: trans-2-enoyl-[acyl-carrier protein]
spontaneous: false
EC number: 4.2.1.59
left: (3R)-3-Hydroxyacyl-[acyl-carrier protein]
name: (3R)-3-Hydroxyacyl-[acyl-carrier protein] → trans-2-enoyl-[acyl-carrier protein] + Water
conversion direction: LEFT_TO_RIGHT

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

2.3.1.41
type: BiochemicalReaction
participant stoichiometry: Protein/Generic135/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/Generic84/Stoichiometry/1.0
participant stoichiometry: Protein/Generic121/Stoichiometry/1.0
participant stoichiometry: Compound/Generic86/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: a holo-[acyl-carrier protein]
right: 3-Oxoacyl-[acyl-carrier protein]
right: Carbon dioxide
spontaneous: false
EC number: 2.3.1.41
left: a malonyl-[acp]
left: Hydrogen Ion
left: 2,3,4-saturated fatty acyl-[acp]
name: 2,3,4-saturated fatty acyl-[acp] + Hydrogen Ion + a malonyl-[acp] → 3-Oxoacyl-[acyl-carrier protein] + Carbon dioxide + a holo-[acyl-carrier protein]
conversion direction: LEFT_TO_RIGHT

1.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Protein/Generic121/Stoichiometry/1.0
participant stoichiometry: Protein/Generic204/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NAD
right: 2,3,4-saturated fatty acyl-[acp]
spontaneous: false
EC number: 1.3.1.9
left: NADH
left: trans-2-enoyl-[acyl-carrier protein]
left: Hydrogen Ion
name: trans-2-enoyl-[acyl-carrier protein] + Hydrogen Ion + NADH → 2,3,4-saturated fatty acyl-[acp] + NAD
conversion direction: LEFT_TO_RIGHT

4.2.1.59
type: BiochemicalReaction
participant stoichiometry: Protein/Generic185/Stoichiometry/1.0
participant stoichiometry: Protein/Generic149/Stoichiometry/1.0
right: cis-Δ3-decenoyl-ACP
spontaneous: false
EC number: 4.2.1.59
left: a trans-Δ2-decenoyl-[acp]
name: a trans-Δ2-decenoyl-[acp] → cis-Δ3-decenoyl-ACP
conversion direction: LEFT_TO_RIGHT

4.2.1.59
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Protein/Generic153/Stoichiometry/1.0
participant stoichiometry: Protein/Generic149/Stoichiometry/1.0
right: Water
right: a trans-Δ2-decenoyl-[acp]
spontaneous: false
EC number: 4.2.1.59
left: an (R)-3-hydroxydecanoyl-[acp]
name: an (R)-3-hydroxydecanoyl-[acp] → Water + a trans-Δ2-decenoyl-[acp]
conversion direction: LEFT_TO_RIGHT

1.3.1.9
type: BiochemicalReaction
participant stoichiometry: Protein/Generic195/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Protein/Generic170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: cis-Δ5-dodecenoyl-[acp]
right: NAD
spontaneous: false
EC number: 1.3.1.9
left: NADH
left: Hydrogen Ion
left: trans-Δ3-cis-Δ5-dodecenoyl-[acp]
name: Hydrogen Ion + NADH + trans-Δ3-cis-Δ5-dodecenoyl-[acp] → NAD + cis-Δ5-dodecenoyl-[acp]
conversion direction: LEFT_TO_RIGHT

2.3.1.41
type: BiochemicalReaction
participant stoichiometry: Protein/Generic127/Stoichiometry/1.0
participant stoichiometry: Protein/Generic185/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/Generic84/Stoichiometry/1.0
participant stoichiometry: Compound/Generic86/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: a holo-[acyl-carrier protein]
right: 3-oxo-cis-Δ5-dodecenoyl-[acp]
right: Carbon dioxide
spontaneous: false
EC number: 2.3.1.41
left: a malonyl-[acp]
left: Hydrogen Ion
left: cis-Δ3-decenoyl-ACP
name: Hydrogen Ion + a malonyl-[acp] + cis-Δ3-decenoyl-ACP → 3-oxo-cis-Δ5-dodecenoyl-[acp] + Carbon dioxide + a holo-[acyl-carrier protein]
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/ChEBI CHEBI 15531
type: UnificationXref
id: CHEBI:15531
db: ChEBI

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

a holo-[acyl-carrier protein]
type: SmallMolecule
entity reference: a holo-[acyl-carrier protein]

a malonyl-[acp]
type: SmallMolecule
entity reference: a malonyl-[acp]

Protein/67211/Stoichiometry/2.0
type: Stoichiometry
physical entity: Beta-ketoacyl-[acyl-carrier-protein] synthase III
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Compound/PW C000940 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

acetyl-CoA carboxylase
type: Complex
component stoichiometry: Protein/29190/Stoichiometry/2.0
component: Unknown

Protein/Generic135 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Oxoacyl-[acyl-carrier protein]
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

a holo-[acyl-carrier protein]
type: SmallMolecule
cellular location: Cytosol
entity reference: a holo-[acyl-carrier protein]

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Protein/Generic204/Stoichiometry/1.0
type: Stoichiometry
physical entity: trans-2-enoyl-[acyl-carrier protein]
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

3-oxoacyl-[acyl-carrier-protein] reductase
type: Protein
entity reference: 3-oxoacyl-[acyl-carrier-protein] reductase

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis1035111
type: Catalysis
controller: acetyl-CoA carboxylase
controlled: 6.4.1.2
control type: ACTIVATION

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Beta-ketoacyl-[acyl-carrier-protein] synthase III
type: Protein
entity reference: Beta-ketoacyl-[acyl-carrier-protein] synthase III

ReactionCatalysis1035115
type: Catalysis
controller: Beta-ketoacyl-ACP synthase
controlled: 2.3.1.180
control type: ACTIVATION

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis1035113
type: Catalysis
controller: Unknown
controlled: 2.3.1.39
control type: ACTIVATION

Reaction1016381
type: BiochemicalReaction
participant stoichiometry: Protein/Generic195/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/Generic216/Stoichiometry/1.0
right: Water
right: trans-Δ3-cis-Δ5-dodecenoyl-[acp]
spontaneous: false
left: a (3R)-hydroxy cis Δ5-dodecenoyl-[acp]
name: a (3R)-hydroxy cis Δ5-dodecenoyl-[acp] → Water + trans-Δ3-cis-Δ5-dodecenoyl-[acp]
conversion direction: LEFT_TO_RIGHT

1.1.1.100
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/Generic135 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/Generic203 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: (3R)-3-Hydroxyacyl-[acyl-carrier protein]
right: NADP
spontaneous: false
EC number: 1.1.1.100
left: 3-Oxoacyl-[acyl-carrier protein]
left: Hydrogen Ion
left: NADPH
name: 3-Oxoacyl-[acyl-carrier protein] + Hydrogen Ion + NADPH → (3R)-3-Hydroxyacyl-[acyl-carrier protein] + NADP
conversion direction: LEFT_TO_RIGHT

1.1.1.100
type: BiochemicalReaction
participant stoichiometry: Protein/Generic127/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/Generic216/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADP
right: a (3R)-hydroxy cis Δ5-dodecenoyl-[acp]
spontaneous: false
EC number: 1.1.1.100
left: 3-oxo-cis-Δ5-dodecenoyl-[acp]
left: Hydrogen Ion
left: NADPH
name: 3-oxo-cis-Δ5-dodecenoyl-[acp] + Hydrogen Ion + NADPH → NADP + a (3R)-hydroxy cis Δ5-dodecenoyl-[acp]
conversion direction: LEFT_TO_RIGHT

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Glycolysis and Pyruvate Dehydrogenase
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway471172
pathway component: SubPathwayInteraction471172
xref: Reference/PathWhiz PW000785
xref: Reference/SMPDB SMP0000807
name: SubPathway

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMolecule
cellular location: Cytosol
entity reference: Coenzyme A

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

3-Oxoacyl-[acyl-carrier protein]
type: Protein
cellular location: Cytosol
entity reference: 3-Oxoacyl-[acyl-carrier protein]

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/UniProt C5ZVR0
type: UnificationXref
id: C5ZVR0
db: UniProt

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

a malonyl-[acp]
type: SmallMoleculeReference

a holo-[acyl-carrier protein]
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00229

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

3-oxoacyl-[acyl-carrier-protein] synthase 2
type: ProteinReference
xref: Reference/UniProt C5ZVC6

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Fatty Acid Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway471173
pathway order: SubPathwayInteractionSteps/SubPathway471174
pathway component: SubPathwayInteraction471174
pathway component: SubPathwayInteraction471173
xref: Reference/PathWhiz PW000796
xref: Reference/SMPDB SMP0000817
name: SubPathway

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

ChemicalStructure/PW C000911
type: ChemicalStructure
structure format: SMILES

2.3.1.180
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/Generic84/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Protein/Generic150/Stoichiometry/1.0
right: Coenzyme A
right: Carbon dioxide
right: acetoacetyl-[acp]
spontaneous: false
EC number: 2.3.1.180
left: a malonyl-[acp]
left: Hydrogen Ion
left: Acetyl-CoA
name: Acetyl-CoA + Hydrogen Ion + a malonyl-[acp] → Carbon dioxide + Coenzyme A + acetoacetyl-[acp]
conversion direction: LEFT_TO_RIGHT

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Reaction1016369
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Protein/Generic183/Stoichiometry/1.0
participant stoichiometry: Compound/Generic84/Stoichiometry/1.0
participant stoichiometry: Compound/Generic86/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Protein/Generic150/Stoichiometry/1.0
right: a holo-[acyl-carrier protein]
right: Carbon dioxide
right: acetoacetyl-[acp]
spontaneous: false
left: a malonyl-[acp]
left: Hydrogen Ion
left: an acetyl-[acp]
name: Hydrogen Ion + a malonyl-[acp] + an acetyl-[acp] → Carbon dioxide + a holo-[acyl-carrier protein] + acetoacetyl-[acp]
conversion direction: LEFT_TO_RIGHT

trans-Δ3-cis-Δ5-dodecenoyl-[acp]
type: ProteinReference

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Compound/PW C000911/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malonyl-CoA
stoichiometric coefficient: 1.0

Protein/Generic121/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2,3,4-saturated fatty acyl-[acp]
stoichiometric coefficient: 1.0

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

6.4.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: Phosphate
right: Malonyl-CoA
spontaneous: false
EC number: 6.4.1.2
left: Hydrogen carbonate
left: Acetyl-CoA
left: Adenosine triphosphate
name: Acetyl-CoA + Adenosine triphosphate + Hydrogen carbonate → Adenosine diphosphate + Hydrogen Ion + Malonyl-CoA + Phosphate
conversion direction: LEFT_TO_RIGHT

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

2.3.1.39
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/Generic84/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911/Stoichiometry/1.0
participant stoichiometry: Compound/Generic86/Stoichiometry/1.0
right: Coenzyme A
right: a malonyl-[acp]
spontaneous: false
EC number: 2.3.1.39
left: a holo-[acyl-carrier protein]
left: Malonyl-CoA
name: Malonyl-CoA + a holo-[acyl-carrier protein] → Coenzyme A + a malonyl-[acp]
conversion direction: LEFT_TO_RIGHT

Reference/PathWhiz PW454551
type: UnificationXref
id: PW454551
db: PathWhiz

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

3-oxo-cis-Δ5-dodecenoyl-[acp]
type: Protein
entity reference: 3-oxo-cis-Δ5-dodecenoyl-[acp]

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Beta-ketoacyl-ACP synthase
type: Complex
component stoichiometry: Protein/67211/Stoichiometry/2.0
component: Beta-ketoacyl-[acyl-carrier-protein] synthase III

Reference/SMPDB SMP0000807
type: UnificationXref
id: SMP0000807
db: SMPDB

2,3,4-saturated fatty acyl-[acp]
type: Protein
entity reference: 2,3,4-saturated fatty acyl-[acp]

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

an acetyl-[acp]
type: Protein
cellular location: Cytosol
entity reference: an acetyl-[acp]

an acetyl-[acp]
type: ProteinReference

Water
type: SmallMolecule
entity reference: Water

cis-Δ3-decenoyl-ACP
type: ProteinReference

Reaction3393
type: BiochemicalReaction
participant stoichiometry: Protein/Generic153/Stoichiometry/1.0
participant stoichiometry: Protein/Generic203/Stoichiometry/1.0
right: an (R)-3-hydroxydecanoyl-[acp]
spontaneous: false
left: (3R)-3-Hydroxyacyl-[acyl-carrier protein]
name: (3R)-3-Hydroxyacyl-[acyl-carrier protein] → an (R)-3-hydroxydecanoyl-[acp]
conversion direction: LEFT_TO_RIGHT

Reference/TAXONOMY 537970
type: UnificationXref
id: 537970
db: TAXONOMY

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Protein/29190 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

3-Oxoacyl-[acyl-carrier protein]
type: Protein
entity reference: 3-Oxoacyl-[acyl-carrier protein]

Protein/Generic153/Stoichiometry/1.0
type: Stoichiometry
physical entity: an (R)-3-hydroxydecanoyl-[acp]
stoichiometric coefficient: 1.0

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Protein/Generic149/Stoichiometry/1.0
type: Stoichiometry
physical entity: a trans-Δ2-decenoyl-[acp]
stoichiometric coefficient: 1.0

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

Reference/SMPDB SMP0000817
type: UnificationXref
id: SMP0000817
db: SMPDB

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

cis-Δ5-dodecenoyl-[acp]
type: ProteinReference

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
type: Protein
entity reference: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

a malonyl-[acp]
type: SmallMolecule
cellular location: Cytosol
entity reference: a malonyl-[acp]

Reference/ChemSpider 10213
type: UnificationXref
id: 10213
db: ChemSpider

Protein/34417/Stoichiometry/4.0
type: Stoichiometry
physical entity: Enoyl-[acyl-carrier-protein] reductase [NADH]
stoichiometric coefficient: 4.0

Protein/Generic127/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-oxo-cis-Δ5-dodecenoyl-[acp]
stoichiometric coefficient: 1.0

Protein/29190/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Protein/34755/Stoichiometry/2.0
type: Stoichiometry
physical entity: 3-oxoacyl-[acyl-carrier-protein] synthase 2
stoichiometric coefficient: 2.0

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 524-14-1
type: UnificationXref
id: 524-14-1
db: CAS

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Protein/Generic150 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: acetoacetyl-[acp]
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01271
type: UnificationXref
id: C01271
db: KEGG Compound

3-oxoacyl-[acyl-carrier-protein] reductase
type: Protein
cellular location: Cytosol
entity reference: 3-oxoacyl-[acyl-carrier-protein] reductase

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000796
type: UnificationXref
id: PW000796
db: PathWhiz

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

ReactionCatalysis1035127
type: Catalysis
controller: KASI
controlled: 2.3.1.41
control type: ACTIVATION

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

ReactionCatalysis1035128
type: Catalysis
controller: enoyl-[acyl-carrier-protein] reductase(NAD)
controlled: 1.3.1.9
control type: ACTIVATION

a trans-Δ2-decenoyl-[acp]
type: ProteinReference

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Protein/Generic150/Stoichiometry/1.0
type: Stoichiometry
physical entity: acetoacetyl-[acp]
stoichiometric coefficient: 1.0

ReactionCatalysis1035132
type: Catalysis
controller: 3-oxoacyl-[acyl-carrier-protein] reductase
controlled: 1.1.1.100
control type: ACTIVATION

ReactionCatalysis1035133
type: Catalysis
controller: 3-hydroxy-acyl-[acyl-carrier-protein] dehydratase
controlled: Reaction1016381
control type: ACTIVATION

acetoacetyl-[acp]
type: ProteinReference

ReactionCatalysis1035130
type: Catalysis
controller: KASI
controlled: Reaction1016378
control type: ACTIVATION

ReactionCatalysis1035131
type: Catalysis
controller: KASIII
controlled: Reaction1016379
control type: ACTIVATION

Reference/UniProt C5ZYR3
type: UnificationXref
id: C5ZYR3
db: UniProt

an (R)-3-hydroxydecanoyl-[acp]
type: ProteinReference

ReactionCatalysis1035134
type: Catalysis
controller: 3-oxoacyl-[acyl-carrier-protein] reductase
controlled: 1.1.1.100
control type: ACTIVATION

Compound/Generic216/Stoichiometry/1.0
type: Stoichiometry
physical entity: a (3R)-hydroxy cis Δ5-dodecenoyl-[acp]
stoichiometric coefficient: 1.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

a (3R)-hydroxy cis Δ5-dodecenoyl-[acp]
type: SmallMoleculeReference

3-Oxoacyl-[acyl-carrier protein]
type: ProteinReference
xref: Reference/KEGG Compound C00685

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Unknown
type: Protein
entity reference: Unknown

Phosphate
type: SmallMolecule
entity reference: Phosphate

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/KEGG Compound C00083
type: UnificationXref
id: C00083
db: KEGG Compound

Compound/Generic86/Stoichiometry/1.0
type: Stoichiometry
physical entity: a holo-[acyl-carrier protein]
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reaction2786
type: BiochemicalReaction
participant stoichiometry: Protein/Generic150 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/Generic135 Cytosol/Stoichiometry/1.0
right: 3-Oxoacyl-[acyl-carrier protein]
spontaneous: false
left: acetoacetyl-[acp]
name: acetoacetyl-[acp] → 3-Oxoacyl-[acyl-carrier protein]
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Malonyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15531
xref: Reference/KEGG Compound C00083
xref: Reference/BioCyc MALONYL-COA
xref: Reference/CAS 524-14-1
xref: Reference/HMDB HMDB0001175
xref: Reference/PubChem-compound 10663
xref: Reference/ChemSpider 10213
chemical formula: C24H38N7O19P3S
molecular weight: 853.1156
structure: ChemicalStructure/PW C000911

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

cis-Δ5-dodecenoyl-[acp]
type: Protein
entity reference: cis-Δ5-dodecenoyl-[acp]

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

3-oxo-cis-Δ5-dodecenoyl-[acp]
type: ProteinReference

Compound/Generic86 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: a holo-[acyl-carrier protein]
stoichiometric coefficient: 1.0

Fatty Acid Biosynthesis
type: Pathway
pathway order: PathwayEnzymeReaction/6402647
pathway order: PathwayEnzymeReaction/6402602
pathway order: PathwayEnzymeReaction/6402635
pathway order: PathwayEnzymeReaction/6402612
pathway order: PathwayEnzymeReaction/6402645
pathway order: PathwayEnzymeReaction/6402633
pathway order: PathwayEnzymeReaction/6402644
pathway order: PathwayEnzymeReaction/6402607
pathway order: PathwayEnzymeReaction/6402618
pathway order: PathwayEnzymeReaction/6402629
pathway order: PathwayEnzymeReaction/6402617
pathway order: PathwayEnzymeReaction/6402616
pathway order: PathwayEnzymeReaction/6402627
pathway order: PathwayEnzymeReaction/6402638
pathway order: PathwayEnzymeReaction/6402649
pathway order: PathwayEnzymeReaction/6402604
pathway order: PathwayEnzymeReaction/6402626
pathway order: PathwaySubPathway/471172
pathway order: PathwayEnzymeReaction/6402599
pathway order: PathwayEnzymeReaction/6402610
pathway order: PathwayEnzymeReaction/6402642
pathway order: PathwaySubPathway/471173
pathway order: PathwaySubPathway/471174
pathway order: PathwayEnzymeReaction/6402608
pathway component: Glycolysis and Pyruvate Dehydrogenase
pathway component: ReactionCatalysis1035118
pathway component: ReactionCatalysis1035119
pathway component: ReactionCatalysis1035117
pathway component: ReactionCatalysis1035121
pathway component: Reaction1016378
pathway component: ReactionCatalysis1035122
pathway component: Reaction1016379
pathway component: ReactionCatalysis1035125
pathway component: ReactionCatalysis1035126
pathway component: ReactionCatalysis1035123
pathway component: Reaction3393
pathway component: ReactionCatalysis1035124
pathway component: 4.2.1.59
pathway component: 2.3.1.41
pathway component: 1.3.1.9
pathway component: Reaction2786
pathway component: Fatty Acid Metabolism
pathway component: ReactionCatalysis1035127
pathway component: ReactionCatalysis1035128
pathway component: 2.3.1.180
pathway component: ReactionCatalysis1035132
pathway component: ReactionCatalysis1035111
pathway component: ReactionCatalysis1035133
pathway component: Reaction1016369
pathway component: ReactionCatalysis1035130
pathway component: ReactionCatalysis1035131
pathway component: ReactionCatalysis1035115
pathway component: ReactionCatalysis1035134
pathway component: ReactionCatalysis1035113
pathway component: Reaction1016381
pathway component: 1.1.1.100
pathway component: 6.4.1.2
pathway component: 2.3.1.39
xref: Reference/PathWhiz PW454551
xref: Reference/SMPDB SMP0438805
organism: Helicobacter canadensis MIT 98-5491

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

KASIII
type: Complex
component stoichiometry: Protein/29190 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

a trans-Δ2-decenoyl-[acp]
type: Protein
entity reference: a trans-Δ2-decenoyl-[acp]

Compound/Generic84 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: a malonyl-[acp]
stoichiometric coefficient: 1.0

Malonyl-CoA
type: SmallMolecule
entity reference: Malonyl-CoA

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
type: ProteinReference
xref: Reference/UniProt C5ZVR0

Reference/PubChem-compound 10663
type: UnificationXref
id: 10663
db: PubChem-compound

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Compound/PW C001099 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Protein/Generic203/Stoichiometry/1.0
type: Stoichiometry
physical entity: (3R)-3-Hydroxyacyl-[acyl-carrier protein]
stoichiometric coefficient: 1.0

Protein/Generic183/Stoichiometry/1.0
type: Stoichiometry
physical entity: an acetyl-[acp]
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

2,3,4-saturated fatty acyl-[acp]
type: ProteinReference

Protein/Generic183 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: an acetyl-[acp]
stoichiometric coefficient: 1.0

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

acetoacetyl-[acp]
type: Protein
entity reference: acetoacetyl-[acp]

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Protein/45926/Stoichiometry/2.0
type: Stoichiometry
physical entity: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

an (R)-3-hydroxydecanoyl-[acp]
type: Protein
entity reference: an (R)-3-hydroxydecanoyl-[acp]

Hydrogen carbonate
type: SmallMolecule
entity reference: Hydrogen carbonate

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CH2O3
molecular weight: 62.000393
structure: ChemicalStructure/PW C000463

Reference/BioCyc MALONYL-COA
type: UnificationXref
id: MALONYL-COA
db: BioCyc

Reference/HMDB HMDB0001175
type: UnificationXref
id: HMDB0001175
db: HMDB