Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

ReactionCatalysis1270337
type: Catalysis
controller: Phosphoribosylaminoimidazole carboxylase ATPase subunit PurK
controlled: 2.1.2.-
control type: ACTIVATION

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

ReactionCatalysis1270331
type: Catalysis
controller: Uncharacterized protein
controlled: 6.3.5.3
control type: ACTIVATION

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

ReactionCatalysis1270332
type: Catalysis
controller: phosphoribosylformylglycinamide cyclo-ligase
controlled: 6.3.3.1
control type: ACTIVATION

ReactionCatalysis1270330
type: Catalysis
controller: Phosphoribosylglycinamide formyltransferase
controlled: 2.1.2.2
control type: ACTIVATION

4-amino-2-methyl-5-phosphomethylpyrimidine
type: SmallMolecule
entity reference: 4-amino-2-methyl-5-phosphomethylpyrimidine

ReactionCatalysis1270335
type: Catalysis
controller: Thiamine-phosphate synthase
controlled: 2.5.1.3
control type: ACTIVATION

4-amino-2-methyl-5-diphosphomethylpyrimidine
type: SmallMolecule
entity reference: 4-amino-2-methyl-5-diphosphomethylpyrimidine

ReactionCatalysis1270336
type: Catalysis
controller: Thiamine-monophosphate kinase
controlled: 2.7.4.16
control type: ACTIVATION

ReactionCatalysis1270333
type: Catalysis
controller: DNA-binding protein HU
controlled: 4.1.99.17
control type: ACTIVATION

Reference/PubChem-compound 1132
type: UnificationXref
id: 1132
db: PubChem-compound

ReactionCatalysis1270334
type: Catalysis
controller: hydroxymethylpyrimidine kinase / phosphohydroxymethylpyrimidine kinase
controlled: 2.7.1.49
control type: ACTIVATION

10-formyl-tetrahydrofolate mono-L-glutamate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 57454
xref: Reference/PubChem-compound 46878370
chemical formula: C20H21N7O7
molecular weight: 471.15134
structure: ChemicalStructure/PW C042909

Reference/HMDB HMDB0001983
type: UnificationXref
id: HMDB0001983
db: HMDB

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

5-Aminoimidazole ribonucleotide
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03373
xref: Reference/HMDB HMDB0001235
xref: Reference/ChEBI CHEBI 28843
xref: Reference/ChemSpider 141854
xref: Reference/CAS 25635-88-5
xref: Reference/PubChem-compound 161500
xref: Reference/BioCyc 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOL
chemical formula: C8H14N3O7P
molecular weight: 295.05695
structure: ChemicalStructure/PW C000955

Reference/UniProt F9DH52
type: UnificationXref
id: F9DH52
db: UniProt

Reference/PubChem-compound 3382778
type: UnificationXref
id: 3382778
db: PubChem-compound

Reference/UniProt F9DJ97
type: UnificationXref
id: F9DJ97
db: UniProt

Reference/UniProt F9DH55
type: UnificationXref
id: F9DH55
db: UniProt

Compound/PW C042960/Stoichiometry/1.0
type: Stoichiometry
physical entity: tetrahydropteroyl mono-L-glutamate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

N1-(5-phospho-β-D-ribosyl)glycinamide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25244572
chemical formula: C7H14N2O8P
molecular weight: 285.04932
structure: ChemicalStructure/PW C042915

5'-Phosphoribosyl-N-formylglycinamide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001308
xref: Reference/CAS 349-34-8
xref: Reference/PubChem-compound 130805
xref: Reference/ChemSpider 115687
xref: Reference/KEGG Compound C04376
xref: Reference/BioCyc 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE
chemical formula: C8H15N2O9P
molecular weight: 314.0515
structure: ChemicalStructure/PW C001007

Compound/PW C040756/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-amino-2-methyl-5-diphosphomethylpyrimidine
stoichiometric coefficient: 1.0

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Reference/PubChem-compound 6137
type: UnificationXref
id: 6137
db: PubChem-compound

Reference/ChEBI CHEBI 17111
type: UnificationXref
id: CHEBI:17111
db: ChEBI

Reference/BioCyc 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE
type: UnificationXref
id: 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE
db: BioCyc

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C001007/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5'-Phosphoribosyl-N-formylglycinamide
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 37737
type: UnificationXref
id: CHEBI:37737
db: ChEBI

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Phosphoribosylamine--glycine ligase
type: ProteinReference
xref: Reference/UniProt F9DLP6

Amidophosphoribosyltransferase
type: ProteinReference
xref: Reference/UniProt F9DIR1

Phosphoribosylformylglycinamidine cyclo-ligase
type: ProteinReference
xref: Reference/UniProt F9DHG8

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Phosphoribosylaminoimidazole carboxylase ATPase subunit PurK
type: ProteinReference
xref: Reference/UniProt F9DME2

Compound/PW C040755/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-amino-2-methyl-5-phosphomethylpyrimidine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18413
type: UnificationXref
id: CHEBI:18413
db: ChEBI

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Reference/BioCyc THIAMINE-P
type: UnificationXref
id: THIAMINE-P
db: BioCyc

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439182
type: UnificationXref
id: 439182
db: PubChem-compound

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/ChEBI CHEBI 58354
type: UnificationXref
id: CHEBI:58354
db: ChEBI

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C04376
type: UnificationXref
id: C04376
db: KEGG Compound

5-Aminoimidazole ribonucleotide
type: SmallMolecule
entity reference: 5-Aminoimidazole ribonucleotide

5'-Phosphoribosyl-N-formylglycinamide
type: SmallMolecule
entity reference: 5'-Phosphoribosyl-N-formylglycinamide

ChemicalStructure/PW C000548
type: ChemicalStructure
structure format: SMILES
structure data: CSCC[C@H](N)C(O)=O

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/CAS 7540-64-9
type: UnificationXref
id: 7540-64-9
db: CAS

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Reference/UniProt F9DHG8
type: UnificationXref
id: F9DHG8
db: UniProt

Reference/ChemSpider 275
type: UnificationXref
id: 275
db: ChemSpider

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/CAS 154-87-0
type: UnificationXref
id: 154-87-0
db: CAS

Reference/ChemSpider 17216355
type: UnificationXref
id: 17216355
db: ChemSpider

Reference/CAS 495-23-8
type: UnificationXref
id: 495-23-8
db: CAS

2.7.4.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001679/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001060/Stoichiometry/1.0
right: Adenosine diphosphate
right: Thiamine pyrophosphate
spontaneous: false
EC number: 2.7.4.16
left: Thiamine monophosphate
left: Adenosine triphosphate
name: Adenosine triphosphate + Thiamine monophosphate → Adenosine diphosphate + Thiamine pyrophosphate
conversion direction: LEFT_TO_RIGHT

2.1.2.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000092/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042915/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001007/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: Phosphate
right: 5'-Phosphoribosyl-N-formylglycinamide
spontaneous: false
EC number: 2.1.2.-
left: N1-(5-phospho-β-D-ribosyl)glycinamide
left: Formic acid
left: Adenosine triphosphate
name: Adenosine triphosphate + Formic acid + N1-(5-phospho-β-D-ribosyl)glycinamide → 5'-Phosphoribosyl-N-formylglycinamide + Adenosine diphosphate + Hydrogen Ion + Phosphate
conversion direction: LEFT_TO_RIGHT

2.5.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042574/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040756/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001679/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Carbon dioxide
right: Thiamine monophosphate
right: Pyrophosphate
spontaneous: false
EC number: 2.5.1.3
left: 2-((2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate
left: Hydrogen Ion
left: 4-amino-2-methyl-5-diphosphomethylpyrimidine
name: 2-((2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate + 4-amino-2-methyl-5-diphosphomethylpyrimidine + Hydrogen Ion → Carbon dioxide + Pyrophosphate + Thiamine monophosphate
conversion direction: LEFT_TO_RIGHT

4-amino-2-methyl-5-phosphomethylpyrimidine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04556
xref: Reference/ChEBI CHEBI 58354
chemical formula: C6H8N3O4P
molecular weight: 217.02634
structure: ChemicalStructure/PW C040755

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

4-amino-2-methyl-5-diphosphomethylpyrimidine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04752
xref: Reference/ChEBI CHEBI 57841
chemical formula: C6H8N3O7P2
molecular weight: 295.98538
structure: ChemicalStructure/PW C040756

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/UniProt F9DLP6
type: UnificationXref
id: F9DLP6
db: UniProt

Compound/PW C000092/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Thiamine Pyrophosphate Biosynthesis
type: Pathway
pathway order: PathwayEnzymeReaction/6909320
pathway order: PathwayEnzymeReaction/6909319
pathway order: PathwayEnzymeReaction/6909318
pathway order: PathwayEnzymeReaction/6909317
pathway order: PathwaySubPathway/518517
pathway order: PathwayEnzymeReaction/6909314
pathway order: PathwayEnzymeReaction/6909313
pathway order: PathwayEnzymeReaction/6909312
pathway order: PathwaySubPathway/518516
pathway order: PathwayEnzymeReaction/6909311
pathway order: PathwayEnzymeReaction/6909310
pathway order: PathwayEnzymeReaction/6909321
pathway component: ReactionCatalysis1270328
pathway component: 2.7.4.16
pathway component: ReactionCatalysis1270329
pathway component: 2.1.2.-
pathway component: ReactionCatalysis1270337
pathway component: 2.5.1.3
pathway component: 6.3.4.13
pathway component: PRPP Biosynthesis
pathway component: 2.1.2.2
pathway component: 2.4.2.14
pathway component: ReactionCatalysis1270331
pathway component: ReactionCatalysis1270332
pathway component: ReactionCatalysis1270330
pathway component: ReactionCatalysis1270335
pathway component: ReactionCatalysis1270336
pathway component: ReactionCatalysis1270333
pathway component: ReactionCatalysis1270334
pathway component: D-Glutamine and D-Glutamate Metabolism
pathway component: 4.1.99.17
pathway component: 2.7.1.49
pathway component: 6.3.5.3
pathway component: 6.3.3.1
xref: Reference/PathWhiz PW491362
xref: Reference/SMPDB SMP0470964
organism: Prevotella pallens ATCC 700821

Reference/SMPDB SMP0000792
type: UnificationXref
id: SMP0000792
db: SMPDB

Reference/KEGG Compound C00119
type: UnificationXref
id: C00119
db: KEGG Compound

Reference/BioCyc GLY
type: UnificationXref
id: GLY
db: BioCyc

Reference/KEGG Compound C00237
type: UnificationXref
id: C00237
db: KEGG Compound

ChemicalStructure/PW C042960
type: ChemicalStructure
structure format: SMILES

2-((2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate
type: SmallMolecule
entity reference: 2-((2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CH33ADO
type: UnificationXref
id: CH33ADO
db: BioCyc

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

Phosphoribosyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00119
xref: Reference/ChemSpider 7062
xref: Reference/CAS 7540-64-9
xref: Reference/HMDB HMDB0000280
xref: Reference/PubChem-compound 7339
xref: Reference/BioCyc PRPP
xref: Reference/ChEBI CHEBI 17111
chemical formula: C5H13O14P3
molecular weight: 389.9518
structure: ChemicalStructure/PW C000190

Reference/ChEBI CHEBI 28843
type: UnificationXref
id: CHEBI:28843
db: ChEBI

Reference/HMDB HMDB0000696
type: UnificationXref
id: HMDB0000696
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/ChemSpider 141854
type: UnificationXref
id: 141854
db: ChemSpider

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Glycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000123
xref: Reference/BioCyc GLY
xref: Reference/ChemSpider 730
xref: Reference/PubChem-compound 5257127
xref: Reference/CAS 56-40-6
xref: Reference/ChEBI CHEBI 15428
xref: Reference/KEGG Compound C00037
chemical formula: C2H5NO2
molecular weight: 75.03203
structure: ChemicalStructure/PW C000078

Thiamine pyrophosphate
type: SmallMolecule
entity reference: Thiamine pyrophosphate

Formic acid
type: SmallMolecule
entity reference: Formic acid

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/ChemSpider 388325
type: UnificationXref
id: 388325
db: ChemSpider

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/CAS 4754-39-6
type: UnificationXref
id: 4754-39-6
db: CAS

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Compound/PW C000500/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/HMDB HMDB0001308
type: UnificationXref
id: HMDB0001308
db: HMDB

Reference/ChEBI CHEBI 57454
type: UnificationXref
id: CHEBI:57454
db: ChEBI

Compound/PW C000955/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Aminoimidazole ribonucleotide
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Compound/PW C001679/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thiamine monophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/UniProt F9DHJ2
type: UnificationXref
id: F9DHJ2
db: UniProt

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/PubChem-compound 5257127
type: UnificationXref
id: 5257127
db: PubChem-compound

5-Phosphoribosylamine
type: SmallMolecule
entity reference: 5-Phosphoribosylamine

Reference/BioCyc 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE
type: UnificationXref
id: 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE
db: BioCyc

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reference/PathWhiz PW000769
type: UnificationXref
id: PW000769
db: PathWhiz

Compound/PW C000190/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosyl pyrophosphate
stoichiometric coefficient: 1.0

5-Phosphoribosylamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001128
xref: Reference/ChEBI CHEBI 37737
xref: Reference/BioCyc 5-P-BETA-D-RIBOSYL-AMINE
xref: Reference/ChemSpider 388939
xref: Reference/KEGG Compound C03090
xref: Reference/PubChem-compound 439905
chemical formula: C5H12NO7P
molecular weight: 229.03514
structure: ChemicalStructure/PW C000882

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Carbon monoxide
type: SmallMolecule
entity reference: Carbon monoxide

Carbon monoxide
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00237
xref: Reference/ChemSpider 275
xref: Reference/PubChem-compound 281
xref: Reference/HMDB HMDB0001361
xref: Reference/ChEBI CHEBI 17245
xref: Reference/CAS 630-08-0
chemical formula: CO
molecular weight: 27.994915
structure: ChemicalStructure/PW C001050

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Reference/UniProt F9DEU6
type: UnificationXref
id: F9DEU6
db: UniProt

Reference/UniProt F9DEU7
type: UnificationXref
id: F9DEU7
db: UniProt

PRPP Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway518517
pathway component: SubPathwayInteraction518517
xref: Reference/PathWhiz PW000909
xref: Reference/SMPDB SMP0000926
name: SubPathway

N1-(5-phospho-β-D-ribosyl)glycinamide
type: SmallMolecule
entity reference: N1-(5-phospho-β-D-ribosyl)glycinamide

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

ChemicalStructure/PW C001679
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(CCOP(O)([O-])=O)SC=[N+]1CC1=CN=C(C)N=C1N

Reference/PubChem-compound 7339
type: UnificationXref
id: 7339
db: PubChem-compound

Reference/CAS 6157-85-3
type: UnificationXref
id: 6157-85-3
db: CAS

Reference/ChEBI CHEBI 17245
type: UnificationXref
id: CHEBI:17245
db: ChEBI

Amidophosphoribosyltransferase
type: Protein
entity reference: Amidophosphoribosyltransferase

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Phosphoribosylaminoimidazole carboxylase ATPase subunit PurK
type: Protein
entity reference: Phosphoribosylaminoimidazole carboxylase ATPase subunit PurK

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Phosphoribosylamine--glycine ligase
type: Protein
entity reference: Phosphoribosylamine--glycine ligase

Phosphoribosylformylglycinamidine cyclo-ligase
type: Protein
entity reference: Phosphoribosylformylglycinamidine cyclo-ligase

10-formyl-tetrahydrofolate mono-L-glutamate
type: SmallMolecule
entity reference: 10-formyl-tetrahydrofolate mono-L-glutamate

Glycine
type: SmallMolecule
entity reference: Glycine

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/UniProt F9DME2
type: UnificationXref
id: F9DME2
db: UniProt

Protein/70864/Stoichiometry/4.0
type: Stoichiometry
physical entity: Amidophosphoribosyltransferase
stoichiometric coefficient: 4.0

Reference/SMPDB SMP0470964
type: UnificationXref
id: SMP0470964
db: SMPDB

Reference/KEGG Compound C03090
type: UnificationXref
id: C03090
db: KEGG Compound

Uncharacterized protein
type: Protein
entity reference: Uncharacterized protein

Phosphoribosyl pyrophosphate
type: SmallMolecule
entity reference: Phosphoribosyl pyrophosphate

Compound/PW C001329/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5'-Deoxyadenosine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0006211
type: UnificationXref
id: HMDB0006211
db: HMDB

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

2-((2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate
type: SmallMoleculeReference
chemical formula: C7H7NO6PS
molecular weight: 263.97318
structure: ChemicalStructure/PW C042574

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine

Compound/PW C042574/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-((2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate
stoichiometric coefficient: 1.0

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/BioCyc MET
type: UnificationXref
id: MET
db: BioCyc

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

ChemicalStructure/PW C001329
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000123
type: UnificationXref
id: HMDB0000123
db: HMDB

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0002666
type: UnificationXref
id: HMDB0002666
db: HMDB

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Compound/PW C000921/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C002662
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOL
type: UnificationXref
id: 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOL
db: BioCyc

L-Methionine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000696
xref: Reference/ChEBI CHEBI 16643
xref: Reference/KEGG Compound C00073
xref: Reference/CAS 63-68-3
xref: Reference/BioCyc MET
xref: Reference/PubChem-compound 6137
xref: Reference/ChemSpider 5907
chemical formula: C5H11NO2S
molecular weight: 149.05106
structure: ChemicalStructure/PW C000548

Compound/PW C000078/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 161500
type: UnificationXref
id: 161500
db: PubChem-compound

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/KEGG Compound C00037
type: UnificationXref
id: C00037
db: KEGG Compound

Reference/PubChem-compound 46878370
type: UnificationXref
id: 46878370
db: PubChem-compound

Reference/SMPDB SMP0000926
type: UnificationXref
id: SMP0000926
db: SMPDB

Protein/42640/Stoichiometry/4.0
type: Stoichiometry
physical entity: hydroxymethylpyrimidine kinase
stoichiometric coefficient: 4.0

Reference/KEGG Compound C04752
type: UnificationXref
id: C04752
db: KEGG Compound

hydroxymethylpyrimidine kinase
type: Protein
entity reference: hydroxymethylpyrimidine kinase

D-Glutamine and D-Glutamate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway518516
pathway component: SubPathwayInteraction518516
xref: Reference/PathWhiz PW000769
xref: Reference/SMPDB SMP0000792
name: SubPathway

Water
type: SmallMolecule
entity reference: Water

Reference/PubChem-compound 22833657
type: UnificationXref
id: 22833657
db: PubChem-compound

Prevotella pallens ATCC 700821
type: BioSource
xref: Reference/TAXONOMY 997353

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/BioCyc 2-(alpha-lactyl)-thpp
type: UnificationXref
id: 2-(alpha-lactyl)-thpp
db: BioCyc

Compound/PW C042915/Stoichiometry/1.0
type: Stoichiometry
physical entity: N1-(5-phospho-β-D-ribosyl)glycinamide
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040756
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(COP([O-])(=O)OP([O-])([O-])=O)C(=N)N1

ChemicalStructure/PW C040755
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(COP([O-])([O-])=O)C(=N)N1

SubPathwayInteraction518516
type: Interaction
name: SubPathwayReaction
name: SubPathway518516Reaction
participant: L-Glutamine

SubPathwayInteraction518517
type: Interaction
name: SubPathway518517Reaction
name: SubPathwayReaction
participant: Phosphoribosyl pyrophosphate

phosphoribosylformylglycinamide cyclo-ligase
type: Complex
component stoichiometry: Protein/70867/Stoichiometry/2.0
component: Phosphoribosylformylglycinamidine cyclo-ligase

Compound/PW C001050/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon monoxide
stoichiometric coefficient: 1.0

Reference/KEGG Compound C04640
type: UnificationXref
id: C04640
db: KEGG Compound

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

Reference/PubChem-compound 25244572
type: UnificationXref
id: 25244572
db: PubChem-compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 7062
type: UnificationXref
id: 7062
db: ChemSpider

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001235
type: UnificationXref
id: HMDB0001235
db: HMDB

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/ChEBI CHEBI 9532
type: UnificationXref
id: CHEBI:9532
db: ChEBI

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

Reference/ChemSpider 2627905
type: UnificationXref
id: 2627905
db: ChemSpider

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

hydroxymethylpyrimidine kinase / phosphohydroxymethylpyrimidine kinase
type: Complex
component stoichiometry: Protein/42640/Stoichiometry/4.0
component: hydroxymethylpyrimidine kinase

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Reference/ChEBI CHEBI 37574
type: UnificationXref
id: CHEBI:37574
db: ChEBI

Reference/KEGG Compound C05198
type: UnificationXref
id: C05198
db: KEGG Compound

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001128
type: UnificationXref
id: HMDB0001128
db: HMDB

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Compound/PW C002662/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
stoichiometric coefficient: 1.0

Reference/CAS 63-68-3
type: UnificationXref
id: 63-68-3
db: CAS

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Reference/HMDB HMDB0001361
type: UnificationXref
id: HMDB0001361
db: HMDB

Thiamine pyrophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc 2-(alpha-lactyl)-thpp
xref: Reference/ChEBI CHEBI 9532
xref: Reference/CAS 154-87-0
xref: Reference/ChemSpider 1100
xref: Reference/HMDB HMDB0001372
xref: Reference/PubChem-compound 1132
xref: Reference/KEGG Compound C00068
chemical formula: C12H19N4O7P2S
molecular weight: 425.04498
structure: ChemicalStructure/PW C001060

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/ChemSpider 5907
type: UnificationXref
id: 5907
db: ChemSpider

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

amidophosphoribosyl transferase
type: Complex
component stoichiometry: Protein/70864/Stoichiometry/4.0
component: Amidophosphoribosyltransferase

Reference/ChEBI CHEBI 16643
type: UnificationXref
id: CHEBI:16643
db: ChEBI

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/UniProt F9DIR1
type: UnificationXref
id: F9DIR1
db: UniProt

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/CAS 349-34-8
type: UnificationXref
id: 349-34-8
db: CAS

Reference/CAS 56-40-6
type: UnificationXref
id: 56-40-6
db: CAS

ChemicalStructure/PW C001007
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

L-Methionine
type: SmallMolecule
entity reference: L-Methionine

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

ChemicalStructure/PW C000955
type: ChemicalStructure
structure format: SMILES

Reference/CAS 630-08-0
type: UnificationXref
id: 630-08-0
db: CAS

Reference/KEGG Compound C00068
type: UnificationXref
id: C00068
db: KEGG Compound

Phosphoribosylglycinamide formyltransferase
type: Protein
entity reference: Phosphoribosylglycinamide formyltransferase

Compound/PW C000548/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 1.0

DNA-binding protein HU
type: Protein
entity reference: DNA-binding protein HU

Reference/KEGG Compound C00073
type: UnificationXref
id: C00073
db: KEGG Compound

Reference/HMDB HMDB0000280
type: UnificationXref
id: HMDB0000280
db: HMDB

Reference/ChEBI CHEBI 15428
type: UnificationXref
id: CHEBI:15428
db: ChEBI

Reference/ChemSpider 115687
type: UnificationXref
id: 115687
db: ChemSpider

Thiamine-phosphate synthase
type: Protein
entity reference: Thiamine-phosphate synthase

Thiamine-monophosphate kinase
type: Protein
entity reference: Thiamine-monophosphate kinase

Reference/HMDB HMDB0001372
type: UnificationXref
id: HMDB0001372
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Thiamine-monophosphate kinase
type: ProteinReference
xref: Reference/UniProt F9DH52

Thiamine-phosphate synthase
type: ProteinReference
xref: Reference/UniProt F9DEU6

DNA-binding protein HU
type: ProteinReference
xref: Reference/UniProt F9DHJ2

6.3.4.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000882/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042915/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: N1-(5-phospho-β-D-ribosyl)glycinamide
right: Phosphate
spontaneous: false
EC number: 6.3.4.13
left: 5-Phosphoribosylamine
left: Glycine
left: Adenosine triphosphate
name: 5-Phosphoribosylamine + Adenosine triphosphate + Glycine → Adenosine diphosphate + Hydrogen Ion + N1-(5-phospho-β-D-ribosyl)glycinamide + Phosphate
conversion direction: LEFT_TO_RIGHT

2.1.2.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C042915/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042960/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001007/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042909/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Hydrogen Ion
right: tetrahydropteroyl mono-L-glutamate
right: 5'-Phosphoribosyl-N-formylglycinamide
spontaneous: false
EC number: 2.1.2.2
left: 10-formyl-tetrahydrofolate mono-L-glutamate
left: N1-(5-phospho-β-D-ribosyl)glycinamide
name: 10-formyl-tetrahydrofolate mono-L-glutamate + N1-(5-phospho-β-D-ribosyl)glycinamide → 5'-Phosphoribosyl-N-formylglycinamide + Hydrogen Ion + tetrahydropteroyl mono-L-glutamate
conversion direction: LEFT_TO_RIGHT

Reference/TAXONOMY 997353
type: UnificationXref
id: 997353
db: TAXONOMY

2.4.2.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000882/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000190/Stoichiometry/1.0
right: L-Glutamic acid
right: 5-Phosphoribosylamine
right: Pyrophosphate
spontaneous: false
EC number: 2.4.2.14
left: Water
left: L-Glutamine
left: Phosphoribosyl pyrophosphate
name: L-Glutamine + Phosphoribosyl pyrophosphate + Water → 5-Phosphoribosylamine + L-Glutamic acid + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Compound/PW C042909/Stoichiometry/1.0
type: Stoichiometry
physical entity: 10-formyl-tetrahydrofolate mono-L-glutamate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 25790919
type: UnificationXref
id: 25790919
db: PubChem-compound

Reference/PubChem-compound 130805
type: UnificationXref
id: 130805
db: PubChem-compound

Reference/KEGG Compound C04556
type: UnificationXref
id: C04556
db: KEGG Compound

Reference/PubChem-compound 281
type: UnificationXref
id: 281
db: PubChem-compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Thiamine monophosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 2627905
xref: Reference/HMDB HMDB0002666
xref: Reference/KEGG Compound C01081
xref: Reference/BioCyc THIAMINE-P
xref: Reference/PubChem-compound 3382778
xref: Reference/ChEBI CHEBI 37574
xref: Reference/CAS 495-23-8
chemical formula: C12H17N4O4PS
molecular weight: 344.0708
structure: ChemicalStructure/PW C001679

Phosphate
type: SmallMolecule
entity reference: Phosphate

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 57841
type: UnificationXref
id: CHEBI:57841
db: ChEBI

Compound/PW C000882/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Phosphoribosylamine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/ChemSpider 730
type: UnificationXref
id: 730
db: ChemSpider

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

4.1.99.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000092/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000955/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001050/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/3.0
participant stoichiometry: Compound/PW C040755/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001329/Stoichiometry/1.0
right: Hydrogen Ion
right: 5'-Deoxyadenosine
right: Carbon monoxide
right: 4-amino-2-methyl-5-phosphomethylpyrimidine
right: Formic acid
right: L-Methionine
spontaneous: false
EC number: 4.1.99.17
left: 5-Aminoimidazole ribonucleotide
left: S-Adenosylmethionine
name: 5-Aminoimidazole ribonucleotide + S-Adenosylmethionine → 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-Deoxyadenosine + Carbon monoxide + Formic acid + 3 Hydrogen Ion + L-Methionine
conversion direction: LEFT_TO_RIGHT

2.7.1.49
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040756/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040755/Stoichiometry/1.0
right: Adenosine diphosphate
right: 4-amino-2-methyl-5-diphosphomethylpyrimidine
spontaneous: false
EC number: 2.7.1.49
left: 4-amino-2-methyl-5-phosphomethylpyrimidine
left: Adenosine triphosphate
name: 4-amino-2-methyl-5-phosphomethylpyrimidine + Adenosine triphosphate → 4-amino-2-methyl-5-diphosphomethylpyrimidine + Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

6.3.5.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001007/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002662/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
right: Adenosine diphosphate
right: L-Glutamic acid
right: Hydrogen Ion
right: Phosphate
spontaneous: false
EC number: 6.3.5.3
left: Water
left: L-Glutamine
left: 5'-Phosphoribosyl-N-formylglycinamide
left: Adenosine triphosphate
name: 5'-Phosphoribosyl-N-formylglycinamide + Adenosine triphosphate + L-Glutamine + Water → 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine + Adenosine diphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

6.3.3.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002662/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000955/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: 5-Aminoimidazole ribonucleotide
right: Phosphate
spontaneous: false
EC number: 6.3.3.1
left: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
left: Adenosine triphosphate
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine + Adenosine triphosphate → 5-Aminoimidazole ribonucleotide + Adenosine diphosphate + Hydrogen Ion + Phosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C042574
type: ChemicalStructure
structure format: SMILES
structure data: [H]\C(COP([O-])([O-])=O)=C1\SC(N=C1C)C([O-])=O

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Phosphoribosylglycinamide formyltransferase
type: ProteinReference
xref: Reference/UniProt F9DJ97

Compound/PW C040034/Stoichiometry/3.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 3.0

Protein/70867/Stoichiometry/2.0
type: Stoichiometry
physical entity: Phosphoribosylformylglycinamidine cyclo-ligase
stoichiometric coefficient: 2.0

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

ChemicalStructure/PW C001060
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 17319
type: UnificationXref
id: CHEBI:17319
db: ChEBI

tetrahydropteroyl mono-L-glutamate
type: SmallMolecule
entity reference: tetrahydropteroyl mono-L-glutamate

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Uncharacterized protein
type: ProteinReference
xref: Reference/UniProt F9DH55

5'-Deoxyadenosine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05198
xref: Reference/ChemSpider 388325
xref: Reference/CAS 4754-39-6
xref: Reference/HMDB HMDB0001983
xref: Reference/ChEBI CHEBI 17319
xref: Reference/BioCyc CH33ADO
xref: Reference/PubChem-compound 439182
chemical formula: C10H13N5O3
molecular weight: 251.10184
structure: ChemicalStructure/PW C001329

Compound/PW C001060/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thiamine pyrophosphate
stoichiometric coefficient: 1.0

S-Adenosylmethionine
type: SmallMolecule
entity reference: S-Adenosylmethionine

2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
type: SmallMolecule
entity reference: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 22833657
xref: Reference/ChEBI CHEBI 18413
xref: Reference/BioCyc 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE
xref: Reference/ChemSpider 17216355
xref: Reference/CAS 6157-85-3
xref: Reference/KEGG Compound C04640
xref: Reference/HMDB HMDB0006211
chemical formula: C6H12N3O8P
molecular weight: 285.0362
structure: ChemicalStructure/PW C002662

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Phosphoribosyl pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoribosyl pyrophosphate
name: SubPathwayOutput

Reference/PubChem-compound 439905
type: UnificationXref
id: 439905
db: PubChem-compound

tetrahydropteroyl mono-L-glutamate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25790919
chemical formula: C19H21N7O6
molecular weight: 443.15643
structure: ChemicalStructure/PW C042960

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

L-Glutamine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamine
name: SubPathwayOutput

5'-Deoxyadenosine
type: SmallMolecule
entity reference: 5'-Deoxyadenosine

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

ChemicalStructure/PW C042909
type: ChemicalStructure
structure format: SMILES

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

Reference/ChemSpider 1100
type: UnificationXref
id: 1100
db: ChemSpider

Reference/BioCyc PRPP
type: UnificationXref
id: PRPP
db: BioCyc

Reference/PathWhiz PW491362
type: UnificationXref
id: PW491362
db: PathWhiz

Reference/KEGG Compound C03373
type: UnificationXref
id: C03373
db: KEGG Compound

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000078
type: ChemicalStructure
structure format: SMILES
structure data: NCC(O)=O

ChemicalStructure/PW C000190
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388939
type: UnificationXref
id: 388939
db: ChemSpider

ReactionCatalysis1270328
type: Catalysis
controller: amidophosphoribosyl transferase
controlled: 2.4.2.14
control type: ACTIVATION

ReactionCatalysis1270329
type: Catalysis
controller: Phosphoribosylamine--glycine ligase
controlled: 6.3.4.13
control type: ACTIVATION

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/CAS 25635-88-5
type: UnificationXref
id: 25635-88-5
db: CAS

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Thiamine monophosphate
type: SmallMolecule
entity reference: Thiamine monophosphate

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

ChemicalStructure/PW C042915
type: ChemicalStructure
structure format: SMILES
structure data: [NH3+]CC(=O)NC1OC(COP([O-])([O-])=O)C(O)C1O

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Reference/PathWhiz PW000909
type: UnificationXref
id: PW000909
db: PathWhiz

Reference/KEGG Compound C01081
type: UnificationXref
id: C01081
db: KEGG Compound

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

ChemicalStructure/PW C000882
type: ChemicalStructure
structure format: SMILES

hydroxymethylpyrimidine kinase
type: ProteinReference
xref: Reference/UniProt F9DEU7

Reference/BioCyc 5-P-BETA-D-RIBOSYL-AMINE
type: UnificationXref
id: 5-P-BETA-D-RIBOSYL-AMINE
db: BioCyc

ChemicalStructure/PW C001050
type: ChemicalStructure
structure format: SMILES
structure data: [C-]#[O+]