7-Aminomethyl-7-carbaguanine ↔ 7-Aminomethyl-7-deazaguanosine
7-aminomethyl-7-deazaguanosine34 in tRNA
6-Carboxy-5,6,7,8-tetrahydropterin + Hydrogen Ion → 7-Deaza-7-carboxyguanine + Ammonium
6-carboxy-5,6,7,8-tetrahydropterin synthase
7-Cyano-7-carbaguanine + 3 Hydrogen Ion + 2 NADPH → 7-Aminomethyl-7-carbaguanine + 2 NADP
7-Deaza-7-carboxyguanine + Adenosine triphosphate + Ammonium → 7-Cyano-7-carbaguanine + Adenosine diphosphate + Hydrogen Ion + Phosphate + Water
7-Aminomethyl-7-carbaguanine + tRNA guanine → 7-aminomethyl-7-deazaguanosine34 in tRNA + Guanine
7-Cyano-7-carbaguanine + 3 Hydrogen Ion + 2 NADPH → 2 NADP + Queuine
7-aminomethyl-7-deazaguanosine34 in tRNA + S-Adenosylmethionine → Adenine + Hydrogen Ion + L-Methionine + epoxyqueuosine
7,8-dihydroneopterin 3'-triphosphate + Water → 6-Carboxy-5,6,7,8-tetrahydropterin + Acetaldehyde + 2 Hydrogen Ion + Triphosphate
Guanosine triphosphate + Water → 7,8-dihydroneopterin 3'-triphosphate + Formic acid + Hydrogen Ion