PathWhiz

Pathway Description

2-O-alpha-Mannosyl-D-glycerate Degradation

Bacteroides intestinalis

Metabolic Pathway

2-O-α-Mannosyl-D-glycerate (MG; also named as Alpha-Mannosylglycerate) is an organic compound that will affect the osmosis in hyperthermophilic archaea and bacteria. In E.coli, 2-O-α-mannosyl-D-glycerate PTS permease (mngA) import MG into cell, and then phosphorylate MG to 2-O-(6-phospho-α-mannosyl)-D-glycerate by phosphocarrier protein HPr. 2-O-(6-phospho-α-mannosyl)-D-glycerate is converted to glyceric acid as well as mannose 6-phosphate by alpha-mannosidase mngB. Finally, glyceric acid is catalyzed to 2-Phospho-D-glyceric acid with ATP as energy source by Glycerate kinase 2. E.coli can't use MG as osmotic stress protection, but it can use MG as a carbon source.

References

2-O-alpha-Mannosyl-D-glycerate Degradation References

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from PW002096

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Visualize Compound Data

		2(α-D-Mannosyl)-D-glycerate
		2-O-(6-Phospho-α-mannosyl)-D-glycerate
		2-Phospho-D-glyceric acid
		Adenosine diphosphate
		Adenosine triphosphate
		Glyceric acid
		Hydrogen Ion
		Mannose 6-phosphate
		Water