Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

ChemicalStructure/PW C042525
type: ChemicalStructure
structure format: SMILES

1-Deoxy-D-xylulose 5-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc DEOXYXYLULOSE-5P
xref: Reference/HMDB HMDB0001213
xref: Reference/CAS 190079-18-6
xref: Reference/KEGG Compound C11437
xref: Reference/ChemSpider 391473
xref: Reference/PubChem-compound 443201
xref: Reference/ChEBI CHEBI 16493
chemical formula: C5H11O7P
molecular weight: 214.02425
structure: ChemicalStructure/PW C000944

Reference/KEGG Compound C00314
type: UnificationXref
id: C00314
db: KEGG Compound

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChEBI CHEBI 16493
type: UnificationXref
id: CHEBI:16493
db: ChEBI

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Compound/PW C001065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

asparagine synthase (glutamine-hydrolyzing)
type: Protein
entity reference: asparagine synthase (glutamine-hydrolyzing)

Compound/PW C000270/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Amino-3-phosphonopropionic acid
stoichiometric coefficient: 1.0

2-Amino-3-oxo-4-phosphonooxybutyrate
type: SmallMolecule
entity reference: 2-Amino-3-oxo-4-phosphonooxybutyrate

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

ChemicalStructure/PW C042531
type: ChemicalStructure
structure format: SMILES

NAD
type: SmallMolecule
entity reference: NAD

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Ammonium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0041827
xref: Reference/CAS 14798-03-9
xref: Reference/PubChem-compound 16741146
xref: Reference/KEGG Compound C01342
xref: Reference/ChEBI CHEBI 28938
xref: Reference/ChemSpider 218
chemical formula: H4N
molecular weight: 18.034374
structure: ChemicalStructure/PW C022608

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/CAS 66-72-8
type: UnificationXref
id: 66-72-8
db: CAS

N-acetylmuramic acid PTS permease
type: Complex
cellular location: Inner Membrane
component: Transcription antiterminator and regulator of RNA stability
component: Membrane protein

Compound/PW C001148/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxal 5'-phosphate
stoichiometric coefficient: 1.0

Methylococcus capsulatus
type: BioSource
xref: Reference/TAXONOMY 414

Reference/ChemSpider 1026
type: UnificationXref
id: 1026
db: ChemSpider

Reference/ChemSpider 1025
type: UnificationXref
id: 1025
db: ChemSpider

Reference/ChemSpider 1024
type: UnificationXref
id: 1024
db: ChemSpider

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/ChemSpider 1023
type: UnificationXref
id: 1023
db: ChemSpider

Reference/ChemSpider 1022
type: UnificationXref
id: 1022
db: ChemSpider

Reference/ChemSpider 1021
type: UnificationXref
id: 1021
db: ChemSpider

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Glyceraldehyde-3-phosphate dehydrogenase
type: Protein
cellular location: Cytosol
entity reference: Glyceraldehyde-3-phosphate dehydrogenase

4-Phospho-D-erythronate
type: SmallMolecule
entity reference: 4-Phospho-D-erythronate

Compound/PW C002936/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Oxo-3-hydroxy-4-phosphobutanoic acid
stoichiometric coefficient: 1.0

2-Amino-3-oxo-4-phosphonooxybutyrate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 441260
xref: Reference/ChEBI CHEBI 16273
chemical formula: C4H8NO7P
molecular weight: 213.00385
structure: ChemicalStructure/PW C041164

Reference/ChemSpider 709
type: UnificationXref
id: 709
db: ChemSpider

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Glyoxylate reductase
type: ProteinReference

1-Deoxy-D-xylulose 5-phosphate
type: SmallMolecule
entity reference: 1-Deoxy-D-xylulose 5-phosphate

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Pyridoxine 5'-phosphate synthase
type: Protein
entity reference: Pyridoxine 5'-phosphate synthase

Reference/KEGG Compound C01796
type: UnificationXref
id: C01796
db: KEGG Compound

4-hydroxythreonine-4-phosphate dehydrogenase
type: Protein
entity reference: 4-hydroxythreonine-4-phosphate dehydrogenase

Reference/CAS 529-96-4
type: UnificationXref
id: 529-96-4
db: CAS

Reaction3327
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000270/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041164/Stoichiometry/1.0
right: 2-Amino-3-phosphonopropionic acid
right: Carbon dioxide
spontaneous: true
left: Hydrogen Ion
left: 2-Amino-3-oxo-4-phosphonooxybutyrate
name: 2-Amino-3-oxo-4-phosphonooxybutyrate + Hydrogen Ion → 2-Amino-3-phosphonopropionic acid + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

3-phosphoserine aminotransferase / phosphohydroxythreonine aminotransferase
type: Complex
component stoichiometry: Protein/27663/Stoichiometry/2.0
component: Unknown

D-Glyceraldehyde 3-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc GAP
xref: Reference/ChEBI CHEBI 17138
xref: Reference/HMDB HMDB0001112
xref: Reference/ChemSpider 709
xref: Reference/KEGG Compound C00661
xref: Reference/PubChem-compound 729
xref: Reference/CAS 591-59-3
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C000869

2.7.1.-
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C001019 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001673 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042525 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042531 Inner Membrane/Stoichiometry/1.0
right: [PTS enzyme I]-L-histidine
right: D-Erythrose 4-phosphate
right: [PTS enzyme I]-Nπ-phospho-L-histidine
spontaneous: false
EC number: 2.7.1.-
left: Erythrose
name: Erythrose → [PTS enzyme I]-Nπ-phospho-L-histidine + D-Erythrose 4-phosphate + [PTS enzyme I]-L-histidine
conversion direction: LEFT_TO_RIGHT

Ammonium
type: SmallMolecule
entity reference: Ammonium

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/CAS 583-50-6
type: UnificationXref
id: 583-50-6
db: CAS

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/BioCyc PYRIDOXAMINE-5P
type: UnificationXref
id: PYRIDOXAMINE-5P
db: BioCyc

Reaction1231268
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000944/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869/Stoichiometry/1.0
right: Carbon dioxide
right: 1-Deoxy-D-xylulose 5-phosphate
spontaneous: false
left: D-Glyceraldehyde 3-phosphate
left: Hydrogen Ion
left: Pyruvic acid
name: D-Glyceraldehyde 3-phosphate + Hydrogen Ion + Pyruvic acid → 1-Deoxy-D-xylulose 5-phosphate + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/PubChem-compound 122357
type: UnificationXref
id: 122357
db: PubChem-compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

2-Oxo-3-hydroxy-4-phosphobutanoic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 27951
xref: Reference/KEGG Compound C06054
xref: Reference/HMDB HMDB0006801
xref: Reference/PubChem-compound 21145142
chemical formula: C4H7O8P
molecular weight: 213.98785
structure: ChemicalStructure/PW C002936

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

O-Phospho-4-hydroxy-L-threonine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C06055
xref: Reference/ChEBI CHEBI 18336
xref: Reference/ChemSpider 389731
xref: Reference/HMDB HMDB0006802
xref: Reference/PubChem-compound 440901
chemical formula: C4H10NO7P
molecular weight: 215.01949
structure: ChemicalStructure/PW C002937

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Reference/KEGG Compound C00250
type: UnificationXref
id: C00250
db: KEGG Compound

Reference/KEGG Compound C00018
type: UnificationXref
id: C00018
db: KEGG Compound

Reference/ChEBI CHEBI 18335
type: UnificationXref
id: CHEBI:18335
db: ChEBI

Reference/ChEBI CHEBI 18336
type: UnificationXref
id: CHEBI:18336
db: ChEBI

O-Phospho-4-hydroxy-L-threonine
type: SmallMolecule
entity reference: O-Phospho-4-hydroxy-L-threonine

Reference/ChemSpider 388659
type: UnificationXref
id: 388659
db: ChemSpider

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/PubChem-compound 441260
type: UnificationXref
id: 441260
db: PubChem-compound

Compound/PW C001783/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

ReactionCoupledTransportCatalysis35882
type: Catalysis
controller: N-acetylmuramic acid PTS permease
controlled: 2.7.1.-
control type: ACTIVATION

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C01342
type: UnificationXref
id: C01342
db: KEGG Compound

Reference/ChEBI CHEBI 16273
type: UnificationXref
id: CHEBI:16273
db: ChEBI

Reference/PubChem-compound 443201
type: UnificationXref
id: 443201
db: PubChem-compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

2-Oxo-3-hydroxy-4-phosphobutanoic acid
type: SmallMolecule
entity reference: 2-Oxo-3-hydroxy-4-phosphobutanoic acid

Transcription antiterminator and regulator of RNA stability
type: Protein
cellular location: Inner Membrane
entity reference: Transcription antiterminator and regulator of RNA stability

Reference/ChEBI CHEBI 17138
type: UnificationXref
id: CHEBI:17138
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

D-Glyceraldehyde 3-phosphate
type: SmallMolecule
entity reference: D-Glyceraldehyde 3-phosphate

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/BioCyc PYRIDOXAL
type: UnificationXref
id: PYRIDOXAL
db: BioCyc

Reference/BioCyc DEOXYXYLULOSE-5P
type: UnificationXref
id: DEOXYXYLULOSE-5P
db: BioCyc

ChemicalStructure/PW C001019
type: ChemicalStructure
structure format: SMILES
structure data: O[C@H](COP(O)(O)=O)[C@@H](O)C=O

ChemicalStructure/PW C001017
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(COP(O)(O)=O)C(CO)=C1O

Reference/KEGG Compound C00279
type: UnificationXref
id: C00279
db: KEGG Compound

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Water
type: SmallMolecule
entity reference: Water

Hydrogen peroxide
type: SmallMolecule
entity reference: Hydrogen peroxide

ChemicalStructure/PW C001148
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/HMDB HMDB0000370
type: UnificationXref
id: HMDB0000370
db: HMDB

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Compound/PW C001019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Erythrose 4-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 389731
type: UnificationXref
id: 389731
db: ChemSpider

D-Erythrose 4-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Erythrose 4-phosphate

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/CAS 65-23-6
type: UnificationXref
id: 65-23-6
db: CAS

Reference/HMDB HMDB0001112
type: UnificationXref
id: HMDB0001112
db: HMDB

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/HMDB HMDB0006801
type: UnificationXref
id: HMDB0006801
db: HMDB

Reference/HMDB HMDB0006802
type: UnificationXref
id: HMDB0006802
db: HMDB

Bifunctional protein HldE
type: ProteinReference

Reference/ChemSpider 3723
type: UnificationXref
id: 3723
db: ChemSpider

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C000164/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/CAS 591-59-3
type: UnificationXref
id: 591-59-3
db: CAS

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/CAS 585-18-2
type: UnificationXref
id: 585-18-2
db: CAS

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Reference/PubChem-compound 3857
type: UnificationXref
id: 3857
db: PubChem-compound

ChemicalStructure/PW C000270
type: ChemicalStructure
structure format: SMILES
structure data: NC(CP(O)(O)=O)C(O)=O

Compound/PW C041164/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Amino-3-oxo-4-phosphonooxybutyrate
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C001106/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxamine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 23956
type: UnificationXref
id: CHEBI:23956
db: ChEBI

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

4-hydroxythreonine-4-phosphate dehydrogenase
type: ProteinReference

Pyridoxine 5'-phosphate synthase
type: ProteinReference

Reference/HMDB HMDB0001491
type: UnificationXref
id: HMDB0001491
db: HMDB

ChemicalStructure/PW C000161
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(O)C(CO)=C(CO)C=N1

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/PubChem-compound 440901
type: UnificationXref
id: 440901
db: PubChem-compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

4-Phospho-D-erythronate
type: SmallMolecule
cellular location: Cytosol
entity reference: 4-Phospho-D-erythronate

Phosphate
type: SmallMolecule
entity reference: Phosphate

Pyridoxamine
type: SmallMolecule
entity reference: Pyridoxamine

asparagine synthase (glutamine-hydrolyzing)
type: ProteinReference

ChemicalStructure/PW C001188
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(CO)C(C=O)=C1O

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Oxoglutaric acid
type: SmallMolecule
entity reference: Oxoglutaric acid

Membrane protein
type: Protein
cellular location: Inner Membrane
entity reference: Membrane protein

Reference/PubChem-compound 729
type: UnificationXref
id: 729
db: PubChem-compound

D-Erythrose 4-phosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: D-Erythrose 4-phosphate

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

4-Phospho-D-erythronate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 696
xref: Reference/ChEBI CHEBI 49003
chemical formula: C4H9O8P
molecular weight: 216.00351
structure: ChemicalStructure/PW C041186

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Transketolase
type: Protein
entity reference: Transketolase

Compound/PW C001017/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxine 5'-phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001197
type: ChemicalStructure
structure format: SMILES
structure data: CC1=NC=C(COP(O)(O)=O)C(CN)=C1O

Reference/CAS 190079-18-6
type: UnificationXref
id: 190079-18-6
db: CAS

Compound/PW C002937/Stoichiometry/1.0
type: Stoichiometry
physical entity: O-Phospho-4-hydroxy-L-threonine
stoichiometric coefficient: 1.0

Reference/CAS 447-05-2
type: UnificationXref
id: 447-05-2
db: CAS

Compound/PW C000869/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glyceraldehyde 3-phosphate
stoichiometric coefficient: 1.0

ReactionCatalysis1461933
type: Catalysis
controller: Pyridoxal kinase
controlled: Reaction1422621
control type: ACTIVATION

ReactionCatalysis1461932
type: Catalysis
controller: Pyridoxine 5'-phosphate oxidase
controlled: 1.4.3.5
control type: ACTIVATION

Compound/PW C001019 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Erythrose 4-phosphate
stoichiometric coefficient: 1.0

ReactionCatalysis1461930
type: Catalysis
controller: Pyridoxal kinase
controlled: 2.7.1.35
control type: ACTIVATION

ReactionCatalysis1461937
type: Catalysis
controller: Pyridoxal kinase
controlled: Reaction1422624
control type: ACTIVATION

Reference/BioCyc PYRIDOXINE-5P
type: UnificationXref
id: PYRIDOXINE-5P
db: BioCyc

Protein/95210/Stoichiometry/2.0
type: Stoichiometry
physical entity: asparagine synthase (glutamine-hydrolyzing)
stoichiometric coefficient: 2.0

ReactionCatalysis1461936
type: Catalysis
controller: Pyridoxine 5'-phosphate oxidase
controlled: Reaction1422623
control type: ACTIVATION

Reference/KEGG Compound C05672
type: UnificationXref
id: C05672
db: KEGG Compound

Compound/PW C042525 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: [PTS enzyme I]-Nπ-phospho-L-histidine
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Unknown
type: Protein
entity reference: Unknown

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

ReactionCatalysis1461923
type: Catalysis
controller: Glyoxylate reductase
controlled: 1.1.1.290
control type: ACTIVATION

ReactionCatalysis1461921
type: Catalysis
controller: erythrose 4-phosphate dehydrogenase
controlled: 1.2.1.72
control type: ACTIVATION

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/HMDB HMDB0041827
type: UnificationXref
id: HMDB0041827
db: HMDB

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

ReactionCatalysis1461928
type: Catalysis
controller: Pyridoxine 5'-phosphate synthase
controlled: 2.6.99.2
control type: ACTIVATION

ReactionCatalysis1461927
type: Catalysis
controller: 4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent
controlled: 1.1.1.262
control type: ACTIVATION

Reference/PathWhiz PW533827
type: UnificationXref
id: PW533827
db: PathWhiz

ReactionCatalysis1461925
type: Catalysis
controller: 3-phosphoserine aminotransferase / phosphohydroxythreonine aminotransferase
controlled: Reaction1422613
control type: ACTIVATION

Compound/PW C001673 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Erythrose
stoichiometric coefficient: 1.0

Erythrose
type: SmallMoleculeReference
xref: Reference/ChemSpider 388659
xref: Reference/ChEBI CHEBI 23956
xref: Reference/PubChem-compound 439574
xref: Reference/CAS 583-50-6
xref: Reference/HMDB HMDB0002649
xref: Reference/KEGG Compound C01796
chemical formula: C4H8O4
molecular weight: 120.04226
structure: ChemicalStructure/PW C001673

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/SMPDB SMP0507596
type: UnificationXref
id: SMP0507596
db: SMPDB

Protein/76914/Stoichiometry/2.0
type: Stoichiometry
physical entity: Transketolase
stoichiometric coefficient: 2.0

Pyridoxal 5'-phosphate
type: SmallMolecule
entity reference: Pyridoxal 5'-phosphate

2-Amino-3-phosphonopropionic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 3723
xref: Reference/KEGG Compound C05672
xref: Reference/CAS 5652-28-8
xref: Reference/PubChem-compound 3857
xref: Reference/HMDB HMDB0000370
xref: Reference/ChEBI CHEBI 244030
chemical formula: C3H8NO5P
molecular weight: 169.014
structure: ChemicalStructure/PW C000270

NADH
type: SmallMolecule
entity reference: NADH

Reference/ChEBI CHEBI 27951
type: UnificationXref
id: CHEBI:27951
db: ChEBI

Erythrose
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Erythrose

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/ChEBI CHEBI 28803
type: UnificationXref
id: CHEBI:28803
db: ChEBI

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Glyoxylate reductase
type: Protein
entity reference: Glyoxylate reductase

Protein/95209/Stoichiometry/8.0
type: Stoichiometry
physical entity: Pyridoxine 5'-phosphate synthase
stoichiometric coefficient: 8.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Pyridoxine 5'-phosphate
type: SmallMolecule
entity reference: Pyridoxine 5'-phosphate

Pyridoxine
type: SmallMolecule
entity reference: Pyridoxine

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Pyruvic acid
type: SmallMolecule
entity reference: Pyruvic acid

ChemicalStructure/PW C001673
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(O)COC([H])(O)[C@]1([H])O

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

Pyridoxine
type: SmallMoleculeReference
xref: Reference/CAS 65-23-6
xref: Reference/ChemSpider 1025
xref: Reference/KEGG Compound C00314
xref: Reference/BioCyc CPD-455
xref: Reference/HMDB HMDB0000239
xref: Reference/ChEBI CHEBI 16709
xref: Reference/PubChem-compound 1054
chemical formula: C8H11NO3
molecular weight: 169.0739
structure: ChemicalStructure/PW C000161

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

2-Amino-3-phosphonopropionic acid
type: SmallMolecule
entity reference: 2-Amino-3-phosphonopropionic acid

Reference/BioCyc PYRIDOXAL PHOSPHATE
type: UnificationXref
id: PYRIDOXAL_PHOSPHATE
db: BioCyc

Reference/KEGG Compound C04261
type: UnificationXref
id: C04261
db: KEGG Compound

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

erythrose 4-phosphate dehydrogenase
type: Complex
component stoichiometry: Protein/51824 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Glyceraldehyde-3-phosphate dehydrogenase

Reference/ChEBI CHEBI 244030
type: UnificationXref
id: CHEBI:244030
db: ChEBI

Pyridoxamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001431
xref: Reference/ChEBI CHEBI 16410
xref: Reference/KEGG Compound C00534
xref: Reference/PubChem-compound 1052
xref: Reference/CAS 85-87-0
xref: Reference/ChemSpider 1023
xref: Reference/BioCyc PYRIDOXAMINE
chemical formula: C8H12N2O2
molecular weight: 168.08987
structure: ChemicalStructure/PW C001106

Reference/GENE ONTOLOGY GO 0070258
type: UnificationXref
id: GO:0070258
db: GENE ONTOLOGY

Reference/BioCyc CPD-455
type: UnificationXref
id: CPD-455
db: BioCyc

[PTS enzyme I]-L-histidine
type: SmallMolecule
cellular location: Inner Membrane
entity reference: [PTS enzyme I]-L-histidine

Reference/PubChem-compound 21145142
type: UnificationXref
id: 21145142
db: PubChem-compound

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

1.2.1.72
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001019 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041186 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: NADH
right: 4-Phospho-D-erythronate
spontaneous: false
EC number: 1.2.1.72
left: NAD
left: D-Erythrose 4-phosphate
left: Water
name: D-Erythrose 4-phosphate + NAD + Water → 4-Phospho-D-erythronate + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 218
type: UnificationXref
id: 218
db: ChemSpider

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Pyridoxal
type: SmallMolecule
entity reference: Pyridoxal

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0001545
type: UnificationXref
id: HMDB0001545
db: HMDB

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Oxygen
type: SmallMolecule
entity reference: Oxygen

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Protein/27663/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Membrane protein
type: ProteinReference
organism: Methylococcus capsulatus

Reference/ChEBI CHEBI 64837
type: UnificationXref
id: CHEBI:64837
db: ChEBI

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001106
type: ChemicalStructure
structure format: SMILES
structure data: CC1=C(O)C(CN)=C(CO)C=N1

Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070258

Reference/HMDB HMDB0001431
type: UnificationXref
id: HMDB0001431
db: HMDB

Reference/HMDB HMDB0001555
type: UnificationXref
id: HMDB0001555
db: HMDB

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Compound/PW C001188/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxal
stoichiometric coefficient: 1.0

Compound/PW C000944/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-Deoxy-D-xylulose 5-phosphate
stoichiometric coefficient: 1.0

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001319
type: UnificationXref
id: HMDB0001319
db: HMDB

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Pyridoxine 5'-phosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 1026
xref: Reference/KEGG Compound C00627
xref: Reference/ChEBI CHEBI 28803
xref: Reference/HMDB HMDB0001319
xref: Reference/BioCyc PYRIDOXINE-5P
xref: Reference/PubChem-compound 1055
xref: Reference/CAS 447-05-2
chemical formula: C8H12NO6P
molecular weight: 249.04022
structure: ChemicalStructure/PW C001017

Protein/91828/Stoichiometry/4.0
type: Stoichiometry
physical entity: Bifunctional protein HldE
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 28938
type: UnificationXref
id: CHEBI:28938
db: ChEBI

Reference/HMDB HMDB0002649
type: UnificationXref
id: HMDB0002649
db: HMDB

D-Erythrose 4-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 48153
xref: Reference/HMDB HMDB0001321
xref: Reference/CAS 585-18-2
xref: Reference/BioCyc ERYTHROSE-4P
xref: Reference/PubChem-compound 122357
xref: Reference/ChemSpider 109096
xref: Reference/KEGG Compound C00279
chemical formula: C4H9O7P
molecular weight: 200.00859
structure: ChemicalStructure/PW C001019

Reference/HMDB HMDB0001321
type: UnificationXref
id: HMDB0001321
db: HMDB

1.4.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001017/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001148/Stoichiometry/1.0
right: Hydrogen peroxide
right: Pyridoxal 5'-phosphate
spontaneous: false
EC number: 1.4.3.5
left: Oxygen
left: Pyridoxine 5'-phosphate
name: Oxygen + Pyridoxine 5'-phosphate → Hydrogen peroxide + Pyridoxal 5'-phosphate
conversion direction: LEFT_TO_RIGHT

Reaction1422621
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001188/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001148/Stoichiometry/1.0
right: Adenosine diphosphate
right: Pyridoxal 5'-phosphate
spontaneous: false
left: Pyridoxal
left: Adenosine triphosphate
name: Adenosine triphosphate + Pyridoxal → Adenosine diphosphate + Pyridoxal 5'-phosphate
conversion direction: LEFT_TO_RIGHT

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reaction1422623
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001197/Stoichiometry/1.0
participant stoichiometry: Compound/PW C022608/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001148/Stoichiometry/1.0
right: Hydrogen peroxide
right: Ammonium
right: Pyridoxal 5'-phosphate
spontaneous: false
left: Water
left: Pyridoxamine 5'-phosphate
left: Oxygen
name: Oxygen + Pyridoxamine 5'-phosphate + Water → Ammonium + Hydrogen peroxide + Pyridoxal 5'-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000239
type: UnificationXref
id: HMDB0000239
db: HMDB

Reaction1422624
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001197/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001106/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Pyridoxamine 5'-phosphate
spontaneous: false
left: Pyridoxamine
left: Adenosine triphosphate
name: Adenosine triphosphate + Pyridoxamine → Adenosine diphosphate + Pyridoxamine 5'-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/ChEBI CHEBI 16709
type: UnificationXref
id: CHEBI:16709
db: ChEBI

Transketolase
type: ProteinReference

Vitamin B6 Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/7307341
pathway order: PathwayEnzymeReaction/7307350
pathway order: PathwayEnzymeReaction/7307338
pathway order: PathwayEnzymeReaction/7307348
pathway order: PathwayEnzymeReaction/7307336
pathway order: PathwayEnzymeReaction/7307358
pathway order: PathwayEnzymeReaction/7307345
pathway order: PathwayEnzymeReaction/7307356
pathway order: PathwayEnzymeReaction/7307333
pathway order: PathwayEnzymeReaction/7307344
pathway order: PathwayEnzymeReaction/7307354
pathway order: PathwayEnzymeReaction/7307342
pathway order: PathwayEnzymeReaction/7307353
pathway component: ReactionCatalysis1461933
pathway component: 2.7.1.-
pathway component: ReactionCatalysis1461932
pathway component: ReactionCatalysis1461930
pathway component: ReactionCoupledTransportCatalysis35882
pathway component: ReactionCatalysis1461937
pathway component: 1.2.1.72
pathway component: ReactionCatalysis1461936
pathway component: 1.4.3.5
pathway component: Reaction1231268
pathway component: Reaction1422621
pathway component: Reaction1422623
pathway component: Reaction1422624
pathway component: ReactionCatalysis1461923
pathway component: ReactionCatalysis1461921
pathway component: ReactionCatalysis1261191
pathway component: 1.1.1.262
pathway component: 2.6.99.2
pathway component: ReactionCatalysis1461928
pathway component: 2.7.1.35
pathway component: ReactionCatalysis1461927
pathway component: ReactionCatalysis1461925
pathway component: 1.1.1.290
pathway component: Reaction1422613
pathway component: Reaction3327
xref: Reference/SMPDB SMP0507596
xref: Reference/PathWhiz PW533827
organism: Methylococcus capsulatus

Reference/PubChem-compound 696
type: UnificationXref
id: 696
db: PubChem-compound

Reference/BioCyc ERYTHROSE-4P
type: UnificationXref
id: ERYTHROSE-4P
db: BioCyc

1.1.1.262
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002937/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041164/Stoichiometry/1.0
right: NADH
right: Hydrogen Ion
right: 2-Amino-3-oxo-4-phosphonooxybutyrate
spontaneous: false
EC number: 1.1.1.262
left: O-Phospho-4-hydroxy-L-threonine
left: NAD
name: NAD + O-Phospho-4-hydroxy-L-threonine → 2-Amino-3-oxo-4-phosphonooxybutyrate + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Pyridoxal 5'-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00018
xref: Reference/PubChem-compound 1051
xref: Reference/BioCyc PYRIDOXAL PHOSPHATE
xref: Reference/CAS 54-47-7
xref: Reference/ChEBI CHEBI 18405
xref: Reference/HMDB HMDB0001491
xref: Reference/ChemSpider 1022
chemical formula: C8H10NO6P
molecular weight: 247.02457
structure: ChemicalStructure/PW C001148

2.6.99.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001017/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000270/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000944/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Water
right: Hydrogen Ion
right: Phosphate
right: Pyridoxine 5'-phosphate
spontaneous: false
EC number: 2.6.99.2
left: 2-Amino-3-phosphonopropionic acid
left: 1-Deoxy-D-xylulose 5-phosphate
name: 1-Deoxy-D-xylulose 5-phosphate + 2-Amino-3-phosphonopropionic acid → Hydrogen Ion + Phosphate + Pyridoxine 5'-phosphate + 2 Water
conversion direction: LEFT_TO_RIGHT

2.7.1.35
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001017/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000161/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: Pyridoxine 5'-phosphate
spontaneous: false
EC number: 2.7.1.35
left: Pyridoxine
left: Adenosine triphosphate
name: Adenosine triphosphate + Pyridoxine → Adenosine diphosphate + Hydrogen Ion + Pyridoxine 5'-phosphate
conversion direction: LEFT_TO_RIGHT

Protein/51824 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Glyceraldehyde-3-phosphate dehydrogenase
stoichiometric coefficient: 4.0

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Reference/HMDB HMDB0001213
type: UnificationXref
id: HMDB0001213
db: HMDB

1.1.1.290
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041186/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002936/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: NADH
right: Hydrogen Ion
right: 2-Oxo-3-hydroxy-4-phosphobutanoic acid
spontaneous: false
EC number: 1.1.1.290
left: NAD
left: 4-Phospho-D-erythronate
name: 4-Phospho-D-erythronate + NAD → 2-Oxo-3-hydroxy-4-phosphobutanoic acid + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Reference/CAS 5652-28-8
type: UnificationXref
id: 5652-28-8
db: CAS

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/CAS 54-47-7
type: UnificationXref
id: 54-47-7
db: CAS

Reaction1422613
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002937/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002936/Stoichiometry/1.0
right: O-Phospho-4-hydroxy-L-threonine
right: Oxoglutaric acid
spontaneous: false
left: L-Glutamic acid
left: 2-Oxo-3-hydroxy-4-phosphobutanoic acid
name: 2-Oxo-3-hydroxy-4-phosphobutanoic acid + L-Glutamic acid ↔ O-Phospho-4-hydroxy-L-threonine + Oxoglutaric acid
conversion direction: REVERSIBLE

Unknown
type: ProteinReference

Reference/BioCyc PYRIDOXAMINE
type: UnificationXref
id: PYRIDOXAMINE
db: BioCyc

Reference/ChEBI CHEBI 16410
type: UnificationXref
id: CHEBI:16410
db: ChEBI

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C041164
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@](N)(C(O)=O)C(=O)COP(O)(O)=O

Bifunctional protein HldE
type: Protein
entity reference: Bifunctional protein HldE

Transcription antiterminator and regulator of RNA stability
type: ProteinReference
organism: Methylococcus capsulatus

Reference/CAS 14798-03-9
type: UnificationXref
id: 14798-03-9
db: CAS

Compound/PW C041186/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Phospho-D-erythronate
stoichiometric coefficient: 1.0

Reference/TAXONOMY 414
type: UnificationXref
id: 414
db: TAXONOMY

Compound/PW C041186 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Phospho-D-erythronate
stoichiometric coefficient: 1.0

Pyridoxal kinase
type: Complex
component stoichiometry: Protein/91828/Stoichiometry/4.0
component: Bifunctional protein HldE

Pyridoxine 5'-phosphate oxidase
type: Complex
component stoichiometry: Protein/95210/Stoichiometry/2.0
component: asparagine synthase (glutamine-hydrolyzing)

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Protein/95208/Stoichiometry/2.0
type: Stoichiometry
physical entity: 4-hydroxythreonine-4-phosphate dehydrogenase
stoichiometric coefficient: 2.0

Compound/PW C042531 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: [PTS enzyme I]-L-histidine
stoichiometric coefficient: 1.0

[PTS enzyme I]-Nπ-phospho-L-histidine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04261
xref: Reference/ChEBI CHEBI 64837
chemical formula: C75H140O17P2
molecular weight: 1374.9565
structure: ChemicalStructure/PW C042525

Reference/CAS 85-87-0
type: UnificationXref
id: 85-87-0
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent
type: Complex
component stoichiometry: Protein/95208/Stoichiometry/2.0
component: 4-hydroxythreonine-4-phosphate dehydrogenase

Pyridoxine 5'-phosphate synthase
type: Complex
component stoichiometry: Protein/95209/Stoichiometry/8.0
component: Pyridoxine 5'-phosphate synthase

ChemicalStructure/PW C000944
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O

Reference/ChEBI CHEBI 48153
type: UnificationXref
id: CHEBI:48153
db: ChEBI

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Pyridoxal
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1050
xref: Reference/CAS 66-72-8
xref: Reference/KEGG Compound C00250
xref: Reference/HMDB HMDB0001545
xref: Reference/ChEBI CHEBI 17310
xref: Reference/ChemSpider 1021
xref: Reference/BioCyc PYRIDOXAL
chemical formula: C8H9NO3
molecular weight: 167.05824
structure: ChemicalStructure/PW C001188

Reference/PubChem-compound 439574
type: UnificationXref
id: 439574
db: PubChem-compound

Reference/ChEBI CHEBI 49003
type: UnificationXref
id: CHEBI:49003
db: ChEBI

ChemicalStructure/PW C041186
type: ChemicalStructure
structure format: SMILES

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

[PTS enzyme I]-L-histidine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00615
chemical formula: C78H144O17P2
molecular weight: 1414.9879
structure: ChemicalStructure/PW C042531

ChemicalStructure/PW C022608
type: ChemicalStructure
structure format: SMILES
structure data: [NH4+]

Reference/KEGG Compound C00627
type: UnificationXref
id: C00627
db: KEGG Compound

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Compound/PW C000134/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/KEGG Compound C06055
type: UnificationXref
id: C06055
db: KEGG Compound

Pyridoxamine 5'-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00647
xref: Reference/BioCyc PYRIDOXAMINE-5P
xref: Reference/HMDB HMDB0001555
xref: Reference/ChEBI CHEBI 18335
xref: Reference/ChemSpider 1024
xref: Reference/CAS 529-96-4
xref: Reference/PubChem-compound 1053
chemical formula: C8H13N2O5P
molecular weight: 248.05621
structure: ChemicalStructure/PW C001197

Reference/KEGG Compound C06054
type: UnificationXref
id: C06054
db: KEGG Compound

Pyridoxamine 5'-phosphate
type: SmallMolecule
entity reference: Pyridoxamine 5'-phosphate

Reference/ChemSpider 391473
type: UnificationXref
id: 391473
db: ChemSpider

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
organism: Methylococcus capsulatus

Reference/PubChem-compound 1050
type: UnificationXref
id: 1050
db: PubChem-compound

Reference/PubChem-compound 1051
type: UnificationXref
id: 1051
db: PubChem-compound

Reference/PubChem-compound 1052
type: UnificationXref
id: 1052
db: PubChem-compound

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Compound/PW C000161/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1053
type: UnificationXref
id: 1053
db: PubChem-compound

Reference/PubChem-compound 1054
type: UnificationXref
id: 1054
db: PubChem-compound

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/PubChem-compound 1055
type: UnificationXref
id: 1055
db: PubChem-compound

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/KEGG Compound C00647
type: UnificationXref
id: C00647
db: KEGG Compound

Compound/PW C001197/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyridoxamine 5'-phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 18405
type: UnificationXref
id: CHEBI:18405
db: ChEBI

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

1-deoxyxylulose-5-phosphate synthase
type: Complex
component stoichiometry: Protein/76914/Stoichiometry/2.0
component: Transketolase

Reference/ChEBI CHEBI 17310
type: UnificationXref
id: CHEBI:17310
db: ChEBI

[PTS enzyme I]-Nπ-phospho-L-histidine
type: SmallMolecule
cellular location: Inner Membrane
entity reference: [PTS enzyme I]-Nπ-phospho-L-histidine

Compound/PW C022608/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonium
stoichiometric coefficient: 1.0

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/KEGG Compound C00534
type: UnificationXref
id: C00534
db: KEGG Compound

Reference/PubChem-compound 16741146
type: UnificationXref
id: 16741146
db: PubChem-compound

ChemicalStructure/PW C000869
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C=O

Reference/BioCyc GAP
type: UnificationXref
id: GAP
db: BioCyc

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

ReactionCatalysis1261191
type: Catalysis
controller: 1-deoxyxylulose-5-phosphate synthase
controlled: Reaction1231268
control type: ACTIVATION

Reference/KEGG Compound C00661
type: UnificationXref
id: C00661
db: KEGG Compound

ChemicalStructure/PW C002936
type: ChemicalStructure
structure format: SMILES
structure data: O[C@H](COP(O)(O)=O)C(=O)C(O)=O

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChemSpider 109096
type: UnificationXref
id: 109096
db: ChemSpider

ChemicalStructure/PW C002937
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H]([C@H](O)COP(O)(O)=O)C(O)=O

Reference/KEGG Compound C00615
type: UnificationXref
id: C00615
db: KEGG Compound

Reference/KEGG Compound C11437
type: UnificationXref
id: C11437
db: KEGG Compound

Compound/PW C001420/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0