N-Acetylmuramate 6-phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25202911
xref: Reference/BioCyc CPD0-881
xref: Reference/ChEBI CHEBI 47968
chemical formula: C11H19NO11P
molecular weight: 372.06958
structure: ChemicalStructure/PW C044522

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Acetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15366
xref: Reference/BioCyc ACET
xref: Reference/CAS 64-19-7
xref: Reference/KEGG Compound C00033
xref: Reference/ChemSpider 171
xref: Reference/HMDB HMDB0000042
xref: Reference/PubChem-compound 176
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C000029

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChEBI CHEBI 58690
type: UnificationXref
id: CHEBI:58690
db: ChEBI

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

MFS transporter
type: Protein
entity reference: MFS transporter

Reference/PubChem-compound 3315
type: UnificationXref
id: 3315
db: PubChem-compound

Glycerol-3-phosphate responsive antiterminator
type: Protein
entity reference: Glycerol-3-phosphate responsive antiterminator

Putative membrane protein FdrA
type: Protein
entity reference: Putative membrane protein FdrA

Compound/PW C044522/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetylmuramate 6-phosphate
stoichiometric coefficient: 1.0

Reference/CAS 64-19-7
type: UnificationXref
id: 64-19-7
db: CAS

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/HMDB HMDB0001062
type: UnificationXref
id: HMDB0001062
db: HMDB

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

PTS transporter subunit EIIC
type: ProteinReference

Reference/PubChem-compound 6133
type: UnificationXref
id: 6133
db: PubChem-compound

Reference/TAXONOMY 649746
type: UnificationXref
id: 649746
db: TAXONOMY

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/ChEBI CHEBI 16264
type: UnificationXref
id: CHEBI:16264
db: ChEBI

Dihydropyrimidinase
type: Protein
entity reference: Dihydropyrimidinase

N-Acetyl-D-Glucosamine 6-Phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15784
xref: Reference/ChemSpider 389821
xref: Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-6-P
xref: Reference/HMDB HMDB0001062
xref: Reference/KEGG Compound C00357
xref: Reference/CAS 102029-88-9
xref: Reference/PubChem-compound 440996
chemical formula: C8H16NO9P
molecular weight: 301.05627
structure: ChemicalStructure/PW C000837

Compound/PW C001010/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Lactic acid
stoichiometric coefficient: 1.0

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

D-Lactic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001311
xref: Reference/ChemSpider 55423
xref: Reference/BioCyc D-LACTATE
xref: Reference/CAS 10326-41-7
xref: Reference/KEGG Compound C00256
xref: Reference/PubChem-compound 61503
xref: Reference/ChEBI CHEBI 42111
chemical formula: C3H6O3
molecular weight: 90.03169
structure: ChemicalStructure/PW C001010

Reference/CAS 528-04-1
type: UnificationXref
id: 528-04-1
db: CAS

Acetomicrobium hydrogeniformans
type: BioSource
xref: Reference/TAXONOMY 649746

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

D-Lactic acid
type: SmallMolecule
entity reference: D-Lactic acid

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Compound/PW C042580/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-glucosamine 6-phosphate
stoichiometric coefficient: 1.0

Reference/BioCyc ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS
type: UnificationXref
id: ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS
db: BioCyc

N-Acetyl-D-Glucosamine 6-Phosphate
type: SmallMolecule
entity reference: N-Acetyl-D-Glucosamine 6-Phosphate

Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-6-P
type: UnificationXref
id: N-ACETYL-D-GLUCOSAMINE-6-P
db: BioCyc

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc D-LACTATE
type: UnificationXref
id: D-LACTATE
db: BioCyc

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C04256
type: UnificationXref
id: C04256
db: KEGG Compound

SubPathwayInteraction564106
type: Interaction
name: SubPathwayReaction
name: SubPathway564106Reaction
participant: D-glucosamine 6-phosphate

SubPathwayInteraction564107
type: Interaction
name: SubPathway564107Reaction
name: SubPathwayReaction
participant: fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Lipopolysaccharide Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway564107
pathway component: SubPathwayInteraction564107
xref: Reference/PathWhiz PW000831
xref: Reference/SMPDB SMP0000851
name: SubPathway

Reference/ChemSpider 393240
type: UnificationXref
id: 393240
db: ChemSpider

Reference/SMPDB SMP0002044
type: UnificationXref
id: SMP0002044
db: SMPDB

Reference/ChemSpider 8140645
type: UnificationXref
id: 8140645
db: ChemSpider

PTS transporter subunit EIIC
type: Protein
entity reference: PTS transporter subunit EIIC

Reference/ChemSpider 55423
type: UnificationXref
id: 55423
db: ChemSpider

1,6-anhydro-N-acetyl-β-muramate
type: SmallMolecule
entity reference: 1,6-anhydro-N-acetyl-β-muramate

MFS transporter
type: ProteinReference

Reference/PathWhiz PW000831
type: UnificationXref
id: PW000831
db: PathWhiz

ReactionCatalysis891536
type: Catalysis
controller: fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
controlled: 2.7.7.23
control type: ACTIVATION

Reference/ChEBI CHEBI 15713
type: UnificationXref
id: CHEBI:15713
db: ChEBI

Glycerol-3-phosphate responsive antiterminator
type: ProteinReference

Putative membrane protein FdrA
type: ProteinReference

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

Reference/PubChem-compound 439174
type: UnificationXref
id: 439174
db: PubChem-compound

ChemicalStructure/PW C040813
type: ChemicalStructure
structure format: SMILES

GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
type: SmallMolecule
entity reference: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/CAS 10326-41-7
type: UnificationXref
id: 10326-41-7
db: CAS

Acetic acid
type: SmallMolecule
entity reference: Acetic acid

N-Acetyl-D-glucosamine
type: SmallMolecule
entity reference: N-Acetyl-D-glucosamine

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GLUCOSAMINE-1P
type: UnificationXref
id: GLUCOSAMINE-1P
db: BioCyc

Reference/PubChem-compound 440272
type: UnificationXref
id: 440272
db: PubChem-compound

Compound/PW C040813/Stoichiometry/1.0
type: Stoichiometry
physical entity: diphosphate
stoichiometric coefficient: 1.0

N-Acetyl-D-glucosamine
type: SmallMoleculeReference
xref: Reference/BioCyc ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS
xref: Reference/ChEBI CHEBI 506227
xref: Reference/HMDB HMDB0000215
xref: Reference/KEGG Compound C00140
xref: Reference/ChemSpider 388319
xref: Reference/PubChem-compound 439174
xref: Reference/CAS 7512-17-6
chemical formula: C8H15NO6
molecular weight: 221.08994
structure: ChemicalStructure/PW C000141

Glucosamine-1P
type: SmallMoleculeReference
xref: Reference/PubChem-compound 9965052
xref: Reference/BioCyc GLUCOSAMINE-1P
xref: Reference/HMDB HMDB0001109
xref: Reference/ChemSpider 8140645
chemical formula: C6H14NO8P
molecular weight: 259.04572
structure: ChemicalStructure/PW C000868

Compound/PW C000868/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosamine-1P
stoichiometric coefficient: 1.0

Reference/ChemSpider 388319
type: UnificationXref
id: 388319
db: ChemSpider

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00357
type: UnificationXref
id: C00357
db: KEGG Compound

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/PubChem-compound 25202911
type: UnificationXref
id: 25202911
db: PubChem-compound

Amidohydrolase
type: ProteinReference

Uridine triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6133
xref: Reference/CAS 63-39-8
xref: Reference/ChemSpider 5903
xref: Reference/ChEBI CHEBI 15713
xref: Reference/KEGG Compound C00075
xref: Reference/HMDB HMDB0000285
xref: Reference/BioCyc UTP
chemical formula: C9H15N2O15P3
molecular weight: 483.96854
structure: ChemicalStructure/PW C000192

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

3.2.1.52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040765/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000141/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041112/Stoichiometry/1.0
right: N-Acetyl-D-glucosamine
right: 1,6-anhydro-N-acetyl-β-muramate
spontaneous: false
EC number: 3.2.1.52
left: Water
left: N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate
name: N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate + Water → 1,6-anhydro-N-acetyl-β-muramate + N-Acetyl-D-glucosamine
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000215
type: UnificationXref
id: HMDB0000215
db: HMDB

Uridine diphosphate-N-acetylglucosamine
type: SmallMoleculeReference
xref: Reference/CAS 528-04-1
xref: Reference/PubChem-compound 445675
xref: Reference/HMDB HMDB0000290
xref: Reference/BioCyc UDP-N-ACETYL-D-GLUCOSAMINE
xref: Reference/KEGG Compound C00043
xref: Reference/ChEBI CHEBI 16264
xref: Reference/ChemSpider 393240
chemical formula: C17H27N3O17P2
molecular weight: 607.08154
structure: ChemicalStructure/PW C000196

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate
type: SmallMolecule
entity reference: N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/PathWhiz PW002030
type: UnificationXref
id: PW002030
db: PathWhiz

diphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 3315
chemical formula: C34H28N6O14S4
molecular weight: 872.0546
structure: ChemicalStructure/PW C040813

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/HMDB HMDB0001311
type: UnificationXref
id: HMDB0001311
db: HMDB

N-Acetyl-glucosamine 1-phosphate
type: SmallMolecule
entity reference: N-Acetyl-glucosamine 1-phosphate

ChemicalStructure/PW C000141
type: ChemicalStructure
structure format: SMILES

Dihydropyrimidinase
type: ProteinReference

N-Acetyl-glucosamine 1-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 7125
xref: Reference/ChemSpider 389248
xref: Reference/HMDB HMDB0001367
xref: Reference/PubChem-compound 440272
xref: Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-1-P
xref: Reference/CAS 6866-69-9
xref: Reference/KEGG Compound C04256
chemical formula: C8H16NO9P
molecular weight: 301.05627
structure: ChemicalStructure/PW C001055

Reference/SMPDB SMP0000851
type: UnificationXref
id: SMP0000851
db: SMPDB

N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 45479497
chemical formula: C19H29N2O12
molecular weight: 477.1726
structure: ChemicalStructure/PW C041112

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/KEGG Compound C00256
type: UnificationXref
id: C00256
db: KEGG Compound

Reference/ChEBI CHEBI 7125
type: UnificationXref
id: CHEBI:7125
db: ChEBI

Reaction1424247
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000196/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001055/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040813/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000192/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Uridine diphosphate-N-acetylglucosamine
right: diphosphate
spontaneous: false
left: N-Acetyl-glucosamine 1-phosphate
left: Hydrogen Ion
left: Uridine triphosphate
name: Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate + Uridine triphosphate → Uridine diphosphate-N-acetylglucosamine + diphosphate
conversion direction: LEFT_TO_RIGHT

Uridine diphosphate-N-acetylglucosamine
type: SmallMolecule
entity reference: Uridine diphosphate-N-acetylglucosamine

Reference/KEGG Compound C00140
type: UnificationXref
id: C00140
db: KEGG Compound

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Compound/PW C001055/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-glucosamine 1-phosphate
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005620
type: UnificationXref
id: GO:0005620
db: GENE ONTOLOGY

Uridine triphosphate
type: SmallMolecule
entity reference: Uridine triphosphate

Reaction1424242
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000029/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000837/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042580/Stoichiometry/1.0
right: D-glucosamine 6-phosphate
right: Acetic acid
spontaneous: false
left: N-Acetyl-D-Glucosamine 6-Phosphate
left: Water
name: N-Acetyl-D-Glucosamine 6-Phosphate + Water → Acetic acid + D-glucosamine 6-phosphate
conversion direction: LEFT_TO_RIGHT

Reaction1424244
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000868/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042580/Stoichiometry/1.0
right: Glucosamine-1P
spontaneous: false
left: D-glucosamine 6-phosphate
name: D-glucosamine 6-phosphate ↔ Glucosamine-1P
conversion direction: REVERSIBLE

Reference/SMPDB SMP0507840
type: UnificationXref
id: SMP0507840
db: SMPDB

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

ChemicalStructure/PW C041303
type: ChemicalStructure
structure format: SMILES

N-Acetylmuramate 6-phosphate
type: SmallMolecule
entity reference: N-Acetylmuramate 6-phosphate

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Glucosamine-1P
type: SmallMolecule
entity reference: Glucosamine-1P

Reference/PubChem-compound 440996
type: UnificationXref
id: 440996
db: PubChem-compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reaction1424236
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040765/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044522/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: N-Acetylmuramate 6-phosphate
spontaneous: false
left: Water
left: 1,6-anhydro-N-acetyl-β-muramate
left: Adenosine triphosphate
name: 1,6-anhydro-N-acetyl-β-muramate + Adenosine triphosphate + Water → Adenosine diphosphate + Hydrogen Ion + N-Acetylmuramate 6-phosphate
conversion direction: LEFT_TO_RIGHT

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/BioCyc ACET
type: UnificationXref
id: ACET
db: BioCyc

Reaction1424239
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000837/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001010/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044522/Stoichiometry/1.0
right: N-Acetyl-D-Glucosamine 6-Phosphate
right: D-Lactic acid
spontaneous: false
left: Water
left: N-Acetylmuramate 6-phosphate
name: N-Acetylmuramate 6-phosphate + Water ↔ D-Lactic acid + N-Acetyl-D-Glucosamine 6-Phosphate
conversion direction: REVERSIBLE

D-glucosamine 6-phosphate
type: SmallMolecule
entity reference: D-glucosamine 6-phosphate
name: SubPathwayInput

D-glucosamine 6-phosphate
type: SmallMoleculeReference
chemical formula: C6H14NO8P
molecular weight: 259.04572
structure: ChemicalStructure/PW C042580

3.5.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041303/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040768/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041112/Stoichiometry/1.0
right: L-Ala-γ-D-Glu-DAP-D-Ala
right: N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate
spontaneous: false
EC number: 3.5.1.28
left: Water
left: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
name: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala + Water → L-Ala-γ-D-Glu-DAP-D-Ala + N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate
conversion direction: LEFT_TO_RIGHT

Compound/PW C040768 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
stoichiometric coefficient: 1.0

ReactionCatalysis1463658
type: Catalysis
controller: N-acetylmuramic acid 6-phosphate etherase
controlled: Reaction1424239
control type: ACTIVATION

ReactionCatalysis1463655
type: Catalysis
controller: Amino acid carrier protein
controlled: Reaction1424236
control type: ACTIVATION

Reference/KEGG Compound C00033
type: UnificationXref
id: C00033
db: KEGG Compound

Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-1-P
type: UnificationXref
id: N-ACETYL-D-GLUCOSAMINE-1-P
db: BioCyc

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Water
type: SmallMolecule
entity reference: Water

Compound/PW C000141/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-D-glucosamine
stoichiometric coefficient: 1.0

ReactionCatalysis1463663
type: Catalysis
controller: Phosphoglucosamine mutase
controlled: Reaction1424244
control type: ACTIVATION

ReactionCatalysis1463661
type: Catalysis
controller: N-acetylglucosamine-6-phosphate deacetylase
controlled: Reaction1424242
control type: ACTIVATION

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

ReactionCatalysis1463647
type: Catalysis
controller: Dihydropyrimidinase
controlled: 3.2.1.52
control type: ACTIVATION

Phosphoglucosamine mutase
type: ProteinReference

L-Ala-γ-D-Glu-DAP-D-Ala
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25202885
chemical formula: C18H30N5O9
molecular weight: 460.20435
structure: ChemicalStructure/PW C041303

Reference/ChEBI CHEBI 47968
type: UnificationXref
id: CHEBI:47968
db: ChEBI

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/HMDB HMDB0001109
type: UnificationXref
id: HMDB0001109
db: HMDB

Reference/KEGG Compound C00043
type: UnificationXref
id: C00043
db: KEGG Compound

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Bifunctional protein GlmU
type: ProteinReference

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Compound/PW C000196/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate-N-acetylglucosamine
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

ReactionCatalysis1463652
type: Catalysis
controller: Putative membrane protein FdrA
controlled: 3.5.1.28
control type: ACTIVATION

ReactionCatalysis1463651
type: Catalysis
controller: Glycerol-3-phosphate responsive antiterminator
controlled: 3.5.1.28
control type: ACTIVATION

Reference/BioCyc UTP
type: UnificationXref
id: UTP
db: BioCyc

Reference/ChEBI CHEBI 15784
type: UnificationXref
id: CHEBI:15784
db: ChEBI

Reference/ChemSpider 389821
type: UnificationXref
id: 389821
db: ChemSpider

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 5903
type: UnificationXref
id: 5903
db: ChemSpider

Compound/PW C041112/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040765
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

ChemicalStructure/PW C000029
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)=O

ChemicalStructure/PW C040768
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

diphosphate
type: SmallMolecule
entity reference: diphosphate

Compound/PW C000837/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-D-Glucosamine 6-Phosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001367
type: UnificationXref
id: HMDB0001367
db: HMDB

Compound/PW C000192/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine triphosphate
stoichiometric coefficient: 1.0

Amino acid carrier protein
type: ProteinReference

Compound/PW C000029/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/PubChem-compound 445675
type: UnificationXref
id: 445675
db: PubChem-compound

Reference/BioCyc UDP-N-ACETYL-D-GLUCOSAMINE
type: UnificationXref
id: UDP-N-ACETYL-D-GLUCOSAMINE
db: BioCyc

Protein/68185/Stoichiometry/4.0
type: Stoichiometry
physical entity: Amidohydrolase
stoichiometric coefficient: 4.0

ChemicalStructure/PW C000837
type: ChemicalStructure
structure format: SMILES

fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
type: Complex
component stoichiometry: Protein/62978/Stoichiometry/3.0
component: Bifunctional protein GlmU
name: SubPathwayInput

Reference/CAS 6866-69-9
type: UnificationXref
id: 6866-69-9
db: CAS

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/ChEBI CHEBI 506227
type: UnificationXref
id: CHEBI:506227
db: ChEBI

ChemicalStructure/PW C001010
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](O)C(O)=O

Compound/PW C040768/Stoichiometry/1.0
type: Stoichiometry
physical entity: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
stoichiometric coefficient: 1.0

Amino acid carrier protein
type: Protein
entity reference: Amino acid carrier protein

1,6-Anhydro-N-acetylmuramic Acid Recycling
type: Pathway
pathway order: PathwayEnzymeReaction/7309872
pathway order: PathwayEnzymeReaction/7309883
pathway order: PathwayEnzymeReaction/7309863
pathway order: PathwayEnzymeReaction/7309875
pathway order: PathwayEnzymeReaction/7309886
pathway order: PathwayTransport/7309888
pathway order: PathwayEnzymeReaction/7309867
pathway order: PathwayEnzymeReaction/7309868
pathway order: PathwayEnzymeReaction/7309879
pathway order: PathwaySubPathway/564107
pathway order: PathwaySubPathway/564106
pathway order: PathwayEnzymeReaction/7309881
pathway component: Transport78712
pathway component: ReactionCatalysis1463647
pathway component: ReactionCatalysis1463658
pathway component: ReactionCatalysis891536
pathway component: ReactionCatalysis1463655
pathway component: ReactionCatalysis1463666
pathway component: TransportCatalysis58347
pathway component: 2.7.7.23
pathway component: Reaction1424236
pathway component: Reaction1424247
pathway component: 3.2.1.52
pathway component: Reaction1424239
pathway component: ReactionCatalysis1463652
pathway component: ReactionCatalysis1463663
pathway component: ReactionCatalysis1463651
pathway component: ReactionCatalysis1463661
pathway component: N-Acetylneuraminate, N-Acetylmannosamine, and N-Acetylglucosamine Degradation
pathway component: Reaction1424242
pathway component: Lipopolysaccharide Biosynthesis
pathway component: 3.5.1.28
pathway component: Reaction1424244
xref: Reference/SMPDB SMP0507840
xref: Reference/PathWhiz PW534105
organism: Acetomicrobium hydrogeniformans

Reference/HMDB HMDB0000042
type: UnificationXref
id: HMDB0000042
db: HMDB

Reference/PubChem-compound 45479497
type: UnificationXref
id: 45479497
db: PubChem-compound

Reference/HMDB HMDB0000285
type: UnificationXref
id: HMDB0000285
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChEBI CHEBI 15366
type: UnificationXref
id: CHEBI:15366
db: ChEBI

Transport78712
type: Transport
participant stoichiometry: Compound/PW C040768 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040768 Periplasmic Space/Stoichiometry/1.0
right: Hydrogen Ion
right: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
spontaneous: false
left: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
left: Hydrogen Ion
name: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala (→), Hydrogen Ion (→) Transport: Acetomicrobium hydrogeniformans, Periplasmic Space to Acetomicrobium hydrogeniformans, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 389248
type: UnificationXref
id: 389248
db: ChemSpider

ChemicalStructure/PW C041112
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD0-881
type: UnificationXref
id: CPD0-881
db: BioCyc

Bifunctional protein GlmU
type: Protein
entity reference: Bifunctional protein GlmU

1,6-anhydro-N-acetyl-β-muramate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58690
chemical formula: C11H16NO7
molecular weight: 274.09268
structure: ChemicalStructure/PW C040765

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
type: SmallMoleculeReference
xref: Reference/PubChem-compound 45479219
chemical formula: C37H57N7O20
molecular weight: 919.36694
structure: ChemicalStructure/PW C040768

Reference/KEGG Compound C00075
type: UnificationXref
id: C00075
db: KEGG Compound

Compound/PW C040768 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
stoichiometric coefficient: 1.0

N-acetylmuramic acid 6-phosphate etherase
type: Complex
component stoichiometry: Protein/31942/Stoichiometry/2.0
component: PTS transporter subunit EIIC

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Compound/PW C041303/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Ala-γ-D-Glu-DAP-D-Ala
stoichiometric coefficient: 1.0

Periplasmic Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005620

Reference/PubChem-compound 9965052
type: UnificationXref
id: 9965052
db: PubChem-compound

Reference/HMDB HMDB0000290
type: UnificationXref
id: HMDB0000290
db: HMDB

Reference/ChemSpider 171
type: UnificationXref
id: 171
db: ChemSpider

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Phosphoglucosamine mutase
type: Protein
entity reference: Phosphoglucosamine mutase

Reference/ChEBI CHEBI 42111
type: UnificationXref
id: CHEBI:42111
db: ChEBI

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

TransportCatalysis58347
type: Catalysis
controller: MFS transporter
controlled: Transport78712
control type: ACTIVATION

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 25202885
type: UnificationXref
id: 25202885
db: PubChem-compound

Compound/PW C040765/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1,6-anhydro-N-acetyl-β-muramate
stoichiometric coefficient: 1.0

GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PathWhiz PW534105
type: UnificationXref
id: PW534105
db: PathWhiz

ChemicalStructure/PW C042580
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 61503
type: UnificationXref
id: 61503
db: PubChem-compound

L-Ala-γ-D-Glu-DAP-D-Ala
type: SmallMolecule
entity reference: L-Ala-γ-D-Glu-DAP-D-Ala

Protein/31942/Stoichiometry/2.0
type: Stoichiometry
physical entity: PTS transporter subunit EIIC
stoichiometric coefficient: 2.0

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

ChemicalStructure/PW C044522
type: ChemicalStructure
structure format: SMILES

Amidohydrolase
type: Protein
entity reference: Amidohydrolase

ChemicalStructure/PW C000868
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000196
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
type: SmallMolecule
cellular location: Cytosol
entity reference: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala

ChemicalStructure/PW C000192
type: ChemicalStructure
structure format: SMILES

Reference/CAS 63-39-8
type: UnificationXref
id: 63-39-8
db: CAS

Reference/PubChem-compound 45479219
type: UnificationXref
id: 45479219
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

ReactionCatalysis1463666
type: Catalysis
controller: fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
controlled: Reaction1424247
control type: ACTIVATION

Hydrogen Ion
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Hydrogen Ion

2.7.7.23
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000868/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001055/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: N-Acetyl-glucosamine 1-phosphate
right: Coenzyme A
right: Hydrogen Ion
spontaneous: false
EC number: 2.7.7.23
left: Acetyl-CoA
left: Glucosamine-1P
name: Acetyl-CoA + Glucosamine-1P → Coenzyme A + Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/CAS 102029-88-9
type: UnificationXref
id: 102029-88-9
db: CAS

Reference/PubChem-compound 176
type: UnificationXref
id: 176
db: PubChem-compound

ChemicalStructure/PW C001055
type: ChemicalStructure
structure format: SMILES

N-acetylglucosamine-6-phosphate deacetylase
type: Complex
component stoichiometry: Protein/68185/Stoichiometry/4.0
component: Amidohydrolase

Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

N-Acetylneuraminate, N-Acetylmannosamine, and N-Acetylglucosamine Degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway564106
pathway component: SubPathwayInteraction564106
xref: Reference/PathWhiz PW002030
xref: Reference/SMPDB SMP0002044
name: SubPathway

Reference/CAS 7512-17-6
type: UnificationXref
id: 7512-17-6
db: CAS

Protein/62978/Stoichiometry/3.0
type: Stoichiometry
physical entity: Bifunctional protein GlmU
stoichiometric coefficient: 3.0