Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/CAS 72496-59-4
type: UnificationXref
id: 72496-59-4
db: CAS

7-Cyano-7-carbaguanine
type: SmallMolecule
entity reference: 7-Cyano-7-carbaguanine

Reaction5184
type: BiochemicalReaction
participant stoichiometry: Compound/PW C007268/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042671/Stoichiometry/1.0
right: 7-Aminomethyl-7-deazaguanosine
spontaneous: true
left: 7-Aminomethyl-7-carbaguanine
name: 7-Aminomethyl-7-carbaguanine ↔ 7-Aminomethyl-7-deazaguanosine
conversion direction: REVERSIBLE

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 13344694
type: UnificationXref
id: 13344694
db: PubChem-compound

Queuine tRNA-ribosyltransferase
type: Protein
entity reference: Queuine tRNA-ribosyltransferase

S-adenosylmethionine:tRNA ribosyltransferase-isomerase
type: Protein
entity reference: S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Helicobacter canadensis MIT 98-5491
type: BioSource
xref: Reference/TAXONOMY 537970

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

7-aminomethyl-7-deazaguanosine34 in tRNA
type: RnaReference

ChemicalStructure/PW C041562
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC2=C(NC(CN2)C(O)=O)C(=O)N1

tRNA guanine
type: RnaReference

Reaction5179
type: BiochemicalReaction
participant stoichiometry: Compound/PW C022608/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041563/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041562/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Ammonium
right: 7-Deaza-7-carboxyguanine
spontaneous: true
left: 6-Carboxy-5,6,7,8-tetrahydropterin
left: Hydrogen Ion
name: 6-Carboxy-5,6,7,8-tetrahydropterin + Hydrogen Ion → 7-Deaza-7-carboxyguanine + Ammonium
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

ReactionCatalysis1240374
type: Catalysis
controller: 6-carboxy-5,6,7,8-tetrahydropterin synthase
controlled: 4.1.2.50
control type: ACTIVATION

ChemicalStructure/PW C042656
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C041563
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

7,8-dihydroneopterin 3'-triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25201779
chemical formula: C9H12N5O13P3
molecular weight: 490.96664
structure: ChemicalStructure/PW C042912

Protein/36670/Stoichiometry/6.0
type: Stoichiometry
physical entity: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase
stoichiometric coefficient: 6.0

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 6137
type: UnificationXref
id: 6137
db: PubChem-compound

Ammonium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0041827
xref: Reference/CAS 14798-03-9
xref: Reference/PubChem-compound 16741146
xref: Reference/KEGG Compound C01342
xref: Reference/ChEBI CHEBI 28938
xref: Reference/ChemSpider 218
chemical formula: H4N
molecular weight: 18.034374
structure: ChemicalStructure/PW C022608

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003379
type: UnificationXref
id: HMDB0003379
db: HMDB

Reference/BioCyc QUEUINE
type: UnificationXref
id: QUEUINE
db: BioCyc

Compound/PW C041287/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7-Cyano-7-carbaguanine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 191792
type: UnificationXref
id: 191792
db: PubChem-compound

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

GTP cyclohydrolase 1
type: ProteinReference
xref: Reference/UniProt C5ZWT0

Compound/PW C001152/Stoichiometry/1.0
type: Stoichiometry
physical entity: Queuine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16235
type: UnificationXref
id: CHEBI:16235
db: ChEBI

2.4.2.29
type: BiochemicalReaction
participant stoichiometry: RNA/111/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007268/Stoichiometry/1.0
participant stoichiometry: RNA/110/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000086/Stoichiometry/1.0
right: Guanine
right: 7-aminomethyl-7-deazaguanosine34 in tRNA
spontaneous: false
EC number: 2.4.2.29
left: tRNA guanine
left: 7-Aminomethyl-7-carbaguanine
name: 7-Aminomethyl-7-carbaguanine + tRNA guanine → 7-aminomethyl-7-deazaguanosine34 in tRNA + Guanine
conversion direction: LEFT_TO_RIGHT

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

2.4.99.17
type: BiochemicalReaction
participant stoichiometry: RNA/111/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000024/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042656/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: epoxyqueuosine
right: Adenine
right: Hydrogen Ion
right: L-Methionine
spontaneous: false
EC number: 2.4.99.17
left: 7-aminomethyl-7-deazaguanosine34 in tRNA
left: S-Adenosylmethionine
name: 7-aminomethyl-7-deazaguanosine34 in tRNA + S-Adenosylmethionine → Adenine + Hydrogen Ion + L-Methionine + epoxyqueuosine
conversion direction: LEFT_TO_RIGHT

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 446357
type: UnificationXref
id: 446357
db: PubChem-compound

Reference/ChemSpider 2683694
type: UnificationXref
id: 2683694
db: ChemSpider

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

6-carboxy-5,6,7,8-tetrahydropterin synthase
type: Complex
component stoichiometry: Protein/36670/Stoichiometry/6.0
component: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase

Reference/UniProt C5ZVV2
type: UnificationXref
id: C5ZVV2
db: UniProt

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

ChemicalStructure/PW C000548
type: ChemicalStructure
structure format: SMILES
structure data: CSCC[C@H](N)C(O)=O

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

ChemicalStructure/PW C042671
type: ChemicalStructure
structure format: SMILES

7-Cyano-7-carbaguanine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 45075
xref: Reference/PubChem-compound 446357
chemical formula: C7H5N5O
molecular weight: 175.04941
structure: ChemicalStructure/PW C041287

Reference/HMDB HMDB0011690
type: UnificationXref
id: HMDB0011690
db: HMDB

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

NADPH
type: SmallMolecule
entity reference: NADPH

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

7-cyano-7-deazaguanine synthase
type: Protein
entity reference: 7-cyano-7-deazaguanine synthase

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

NADPH-dependent 7-cyano-7-deazaguanine reductase
type: Protein
entity reference: NADPH-dependent 7-cyano-7-deazaguanine reductase

Compound/PW C000092/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

7-cyano-7-deazaguanine synthase
type: ProteinReference
xref: Reference/UniProt C5ZVV2

Adenine
type: SmallMolecule
entity reference: Adenine

NADP
type: SmallMolecule
entity reference: NADP

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Queuine tRNA-ribosyltransferase
type: ProteinReference
xref: Reference/UniProt C5ZVX7

Adenine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000034
xref: Reference/BioCyc ADENINE
xref: Reference/PubChem-compound 190
xref: Reference/ChemSpider 185
xref: Reference/KEGG Compound C00147
xref: Reference/ChEBI CHEBI 16708
xref: Reference/CAS 73-24-5
chemical formula: C5H5N5
molecular weight: 135.05449
structure: ChemicalStructure/PW C000024

NADPH-dependent 7-cyano-7-deazaguanine reductase
type: ProteinReference
xref: Reference/UniProt C5ZV74

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

S-adenosylmethionine:tRNA ribosyltransferase-isomerase
type: ProteinReference
xref: Reference/UniProt C5ZZ68

Reference/KEGG Compound C01449
type: UnificationXref
id: C01449
db: KEGG Compound

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Ammonium
type: SmallMolecule
entity reference: Ammonium

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Triphosphate
type: SmallMolecule
entity reference: Triphosphate

Reference/ChemSpider 218
type: UnificationXref
id: 218
db: ChemSpider

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Compound/PW C000086/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine
stoichiometric coefficient: 1.0

7-Aminomethyl-7-carbaguanine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0011690
xref: Reference/ChemSpider 166
xref: Reference/PubChem-compound 171
xref: Reference/KEGG Compound C16675
xref: Reference/ChEBI CHEBI 45126
chemical formula: C7H9N5O
molecular weight: 179.0807
structure: ChemicalStructure/PW C007268

Reference/CAS 14127-68-5
type: UnificationXref
id: 14127-68-5
db: CAS

Reference/HMDB HMDB0000696
type: UnificationXref
id: HMDB0000696
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/UniProt C5ZZ68
type: UnificationXref
id: C5ZZ68
db: UniProt

GTP cyclohydrolase 1
type: Protein
entity reference: GTP cyclohydrolase 1

Formic acid
type: SmallMolecule
entity reference: Formic acid

7-Aminomethyl-7-deazaguanosine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 191792
chemical formula: C12H17N5O5
molecular weight: 311.12296
structure: ChemicalStructure/PW C042671

Reference/ChEBI CHEBI 61032
type: UnificationXref
id: CHEBI:61032
db: ChEBI

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/PubChem-compound 53477731
type: UnificationXref
id: 53477731
db: PubChem-compound

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Reference/BioCyc ADENINE
type: UnificationXref
id: ADENINE
db: BioCyc

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Endocytosis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway512757
pathway component: SubPathwayInteraction512757
name: SubPathway

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/KEGG Compound C00242
type: UnificationXref
id: C00242
db: KEGG Compound

RNA/110/Stoichiometry/1.0
type: Stoichiometry
physical entity: tRNA guanine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Guanine
type: SmallMolecule
entity reference: Guanine

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000024
type: ChemicalStructure
structure format: SMILES
structure data: NC1=C2NC=NC2=NC=N1

Guanine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 764
xref: Reference/ChEBI CHEBI 16235
xref: Reference/CAS 73-40-5
xref: Reference/BioCyc GUANINE
xref: Reference/KEGG Compound C00242
xref: Reference/HMDB HMDB0000132
xref: Reference/ChemSpider 744
chemical formula: C5H5N5O
molecular weight: 151.04941
structure: ChemicalStructure/PW C000086

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Compound/PW C000146/Stoichiometry/2.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 2.0

tRNA guanine
type: Rna
entity reference: tRNA guanine

7-aminomethyl-7-deazaguanosine34 in tRNA
type: Rna
entity reference: 7-aminomethyl-7-deazaguanosine34 in tRNA

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Compound/PW C042671/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7-Aminomethyl-7-deazaguanosine
stoichiometric coefficient: 1.0

Reference/BioCyc GUANINE
type: UnificationXref
id: GUANINE
db: BioCyc

Compound/PW C000784/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetaldehyde
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01342
type: UnificationXref
id: C01342
db: KEGG Compound

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Reference/UniProt C5ZWT0
type: UnificationXref
id: C5ZWT0
db: UniProt

Reference/ChEBI CHEBI 28938
type: UnificationXref
id: CHEBI:28938
db: ChEBI

7,8-dihydroneopterin 3'-triphosphate
type: SmallMolecule
entity reference: 7,8-dihydroneopterin 3'-triphosphate

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

7-Aminomethyl-7-carbaguanine
type: SmallMolecule
entity reference: 7-Aminomethyl-7-carbaguanine

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/ChEBI CHEBI 45126
type: UnificationXref
id: CHEBI:45126
db: ChEBI

Reference/ChEBI CHEBI 16708
type: UnificationXref
id: CHEBI:16708
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/BioCyc MET
type: UnificationXref
id: MET
db: BioCyc

Reference/KEGG Compound C00147
type: UnificationXref
id: C00147
db: KEGG Compound

Compound/PW C041562/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-Carboxy-5,6,7,8-tetrahydropterin
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMolecule
entity reference: Guanosine triphosphate
name: SubPathwayOutput

Protein/86184/Stoichiometry/3.0
type: Stoichiometry
physical entity: Queuine tRNA-ribosyltransferase
stoichiometric coefficient: 3.0

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Queuine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C01449
xref: Reference/ChEBI CHEBI 17433
xref: Reference/ChemSpider 30776547
xref: Reference/CAS 72496-59-4
xref: Reference/PubChem-compound 53477731
xref: Reference/BioCyc QUEUINE
xref: Reference/HMDB HMDB0001495
chemical formula: C12H15N5O3
molecular weight: 277.1175
structure: ChemicalStructure/PW C001152

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Compound/PW C000921/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Queuine
type: SmallMolecule
entity reference: Queuine

Reference/CAS 73-24-5
type: UnificationXref
id: 73-24-5
db: CAS

Reference/UniProt C5ZYF2
type: UnificationXref
id: C5ZYF2
db: UniProt

Reference/PubChem-compound 764
type: UnificationXref
id: 764
db: PubChem-compound

L-Methionine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000696
xref: Reference/ChEBI CHEBI 16643
xref: Reference/KEGG Compound C00073
xref: Reference/CAS 63-68-3
xref: Reference/BioCyc MET
xref: Reference/PubChem-compound 6137
xref: Reference/ChemSpider 5907
chemical formula: C5H11NO2S
molecular weight: 149.05106
structure: ChemicalStructure/PW C000548

epoxyqueuosine
type: SmallMolecule
entity reference: epoxyqueuosine

Compound/PW C000143/Stoichiometry/2.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 2.0

6-Carboxy-5,6,7,8-tetrahydropterin
type: SmallMolecule
entity reference: 6-Carboxy-5,6,7,8-tetrahydropterin

Protein/67220/Stoichiometry/10.0
type: Stoichiometry
physical entity: GTP cyclohydrolase 1
stoichiometric coefficient: 10.0

7-Deaza-7-carboxyguanine
type: SmallMolecule
entity reference: 7-Deaza-7-carboxyguanine

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

2-hydroxy-6-oxohepta-2,4-dienoate hydrolase
type: ProteinReference
xref: Reference/UniProt C5ZYF2

Reference/ChEBI CHEBI 18036
type: UnificationXref
id: CHEBI:18036
db: ChEBI

GTP cyclohydrolase I
type: Complex
component stoichiometry: Protein/67220/Stoichiometry/10.0
component: GTP cyclohydrolase 1

Water
type: SmallMolecule
entity reference: Water

Compound/PW C000024/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenine
stoichiometric coefficient: 1.0

Reference/TAXONOMY 537970
type: UnificationXref
id: 537970
db: TAXONOMY

ChemicalStructure/PW C041287
type: ChemicalStructure
structure format: SMILES
structure data: OC1=NC(=N)NC2=C1C(=CN2)C#N

Reference/HMDB HMDB0000132
type: UnificationXref
id: HMDB0000132
db: HMDB

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001152
type: ChemicalStructure
structure format: SMILES

Reference/CAS 73-40-5
type: UnificationXref
id: 73-40-5
db: CAS

Reference/CAS 14798-03-9
type: UnificationXref
id: 14798-03-9
db: CAS

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

Protein/86182/Stoichiometry/2.0
type: Stoichiometry
physical entity: NADPH-dependent 7-cyano-7-deazaguanine reductase
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Reference/HMDB HMDB0000034
type: UnificationXref
id: HMDB0000034
db: HMDB

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

2-hydroxy-6-oxohepta-2,4-dienoate hydrolase
type: Protein
entity reference: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase

Reference/CAS 63-68-3
type: UnificationXref
id: 63-68-3
db: CAS

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

7-Aminomethyl-7-deazaguanosine
type: SmallMolecule
entity reference: 7-Aminomethyl-7-deazaguanosine

Compound/PW C041563/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7-Deaza-7-carboxyguanine
stoichiometric coefficient: 1.0

Reference/ChemSpider 5907
type: UnificationXref
id: 5907
db: ChemSpider

6-Carboxy-5,6,7,8-tetrahydropterin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 61032
xref: Reference/PubChem-compound 44123380
xref: Reference/HMDB HMDB0060410
chemical formula: C7H9N5O3
molecular weight: 211.07054
structure: ChemicalStructure/PW C041562

7-Deaza-7-carboxyguanine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 61125
xref: Reference/PubChem-compound 13344694
chemical formula: C7H6N4O3
molecular weight: 194.04399
structure: ChemicalStructure/PW C041563

ChemicalStructure/PW C022608
type: ChemicalStructure
structure format: SMILES
structure data: [NH4+]

Reference/PubChem-compound 44123380
type: UnificationXref
id: 44123380
db: PubChem-compound

Reference/ChEBI CHEBI 16643
type: UnificationXref
id: CHEBI:16643
db: ChEBI

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

epoxyqueuosine
type: SmallMoleculeReference
chemical formula: C17H23N5O8
molecular weight: 425.15466
structure: ChemicalStructure/PW C042656

Compound/PW C042912/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7,8-dihydroneopterin 3'-triphosphate
stoichiometric coefficient: 1.0

Acetaldehyde
type: SmallMolecule
entity reference: Acetaldehyde

Triphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00536
xref: Reference/HMDB HMDB0003379
xref: Reference/CAS 14127-68-5
xref: Reference/ChemSpider 2683694
xref: Reference/PubChem-compound 3440921
xref: Reference/ChEBI CHEBI 18036
chemical formula: H5O10P3
molecular weight: 257.90955
structure: ChemicalStructure/PW C001868

L-Methionine
type: SmallMolecule
entity reference: L-Methionine

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Compound/PW C000548/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00073
type: UnificationXref
id: C00073
db: KEGG Compound

Reference/PubChem-compound 25201779
type: UnificationXref
id: 25201779
db: PubChem-compound

Acetaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15343
xref: Reference/KEGG Compound C00084
xref: Reference/CAS 75-07-0
xref: Reference/BioCyc ACETALD
xref: Reference/ChemSpider 172
xref: Reference/PubChem-compound 177
xref: Reference/HMDB HMDB0000990
chemical formula: C2H4O
molecular weight: 44.026215
structure: ChemicalStructure/PW C000784

Reference/PubChem-compound 3440921
type: UnificationXref
id: 3440921
db: PubChem-compound

Reference/HMDB HMDB0060410
type: UnificationXref
id: HMDB0060410
db: HMDB

Reference/ChEBI CHEBI 61125
type: UnificationXref
id: CHEBI:61125
db: ChEBI

Reference/HMDB HMDB0001495
type: UnificationXref
id: HMDB0001495
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Reference/SMPDB SMP0645438
type: UnificationXref
id: SMP0645438
db: SMPDB

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/UniProt C5ZVX7
type: UnificationXref
id: C5ZVX7
db: UniProt

Reference/UniProt C5ZV74
type: UnificationXref
id: C5ZV74
db: UniProt

Phosphate
type: SmallMolecule
entity reference: Phosphate

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

tRNA-guanine transglycosylase
type: Complex
component stoichiometry: Protein/86184/Stoichiometry/3.0
component: Queuine tRNA-ribosyltransferase

Reference/KEGG Compound C00084
type: UnificationXref
id: C00084
db: KEGG Compound

3.5.4.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000092/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042912/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Hydrogen Ion
right: 7,8-dihydroneopterin 3'-triphosphate
right: Formic acid
spontaneous: false
EC number: 3.5.4.16
left: Water
left: Guanosine triphosphate
name: Guanosine triphosphate + Water → 7,8-dihydroneopterin 3'-triphosphate + Formic acid + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

7-cyano-7-deazaguanine reductase
type: Complex
component stoichiometry: Protein/86182/Stoichiometry/2.0
component: NADPH-dependent 7-cyano-7-deazaguanine reductase

Reference/CAS 75-07-0
type: UnificationXref
id: 75-07-0
db: CAS

Reference/ChemSpider 172
type: UnificationXref
id: 172
db: ChemSpider

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Compound/PW C040034/Stoichiometry/3.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 3.0

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 17433
type: UnificationXref
id: CHEBI:17433
db: ChEBI

Reference/ChemSpider 30776547
type: UnificationXref
id: 30776547
db: ChemSpider

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

4.1.2.50
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042912/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001868/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000784/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041562/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
right: 6-Carboxy-5,6,7,8-tetrahydropterin
right: Hydrogen Ion
right: Triphosphate
right: Acetaldehyde
spontaneous: false
EC number: 4.1.2.50
left: Water
left: 7,8-dihydroneopterin 3'-triphosphate
name: 7,8-dihydroneopterin 3'-triphosphate + Water → 6-Carboxy-5,6,7,8-tetrahydropterin + Acetaldehyde + 2 Hydrogen Ion + Triphosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Reference/BioCyc ACETALD
type: UnificationXref
id: ACETALD
db: BioCyc

6.3.4.20
type: BiochemicalReaction
participant stoichiometry: Compound/PW C022608/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041287/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041563/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Water
right: 7-Cyano-7-carbaguanine
right: Hydrogen Ion
right: Phosphate
spontaneous: false
EC number: 6.3.4.20
left: Ammonium
left: 7-Deaza-7-carboxyguanine
left: Adenosine triphosphate
name: 7-Deaza-7-carboxyguanine + Adenosine triphosphate + Ammonium → 7-Cyano-7-carbaguanine + Adenosine diphosphate + Hydrogen Ion + Phosphate + Water
conversion direction: LEFT_TO_RIGHT

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

1.7.1.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/2.0
participant stoichiometry: Compound/PW C007268/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/2.0
participant stoichiometry: Compound/PW C041287/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/3.0
right: 7-Aminomethyl-7-carbaguanine
right: NADP
spontaneous: false
EC number: 1.7.1.13
left: 7-Cyano-7-carbaguanine
left: Hydrogen Ion
left: NADPH
name: 7-Cyano-7-carbaguanine + 3 Hydrogen Ion + 2 NADPH → 7-Aminomethyl-7-carbaguanine + 2 NADP
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reaction1211158
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/2.0
participant stoichiometry: Compound/PW C041287/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/3.0
participant stoichiometry: Compound/PW C001152/Stoichiometry/1.0
right: Queuine
right: NADP
spontaneous: false
left: 7-Cyano-7-carbaguanine
left: Hydrogen Ion
left: NADPH
name: 7-Cyano-7-carbaguanine + 3 Hydrogen Ion + 2 NADPH → 2 NADP + Queuine
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

S-Adenosylmethionine
type: SmallMolecule
entity reference: S-Adenosylmethionine

ChemicalStructure/PW C001868
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(=O)OP(O)(O)=O

RNA/111/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7-aminomethyl-7-deazaguanosine34 in tRNA
stoichiometric coefficient: 1.0

Compound/PW C022608/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonium
stoichiometric coefficient: 1.0

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PathWhiz PW685783
type: UnificationXref
id: PW685783
db: PathWhiz

Reference/ChEBI CHEBI 45075
type: UnificationXref
id: CHEBI:45075
db: ChEBI

ChemicalStructure/PW C000784
type: ChemicalStructure
structure format: SMILES
structure data: CC=O

Reference/ChemSpider 166
type: UnificationXref
id: 166
db: ChemSpider

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Reference/ChEBI CHEBI 15343
type: UnificationXref
id: CHEBI:15343
db: ChEBI

Reference/KEGG Compound C00536
type: UnificationXref
id: C00536
db: KEGG Compound

Compound/PW C007268/Stoichiometry/1.0
type: Stoichiometry
physical entity: 7-Aminomethyl-7-carbaguanine
stoichiometric coefficient: 1.0

PreQ0 Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/6850709
pathway order: PathwaySubPathway/512757
pathway order: PathwayEnzymeReaction/6850706
pathway order: PathwayEnzymeReaction/6850707
pathway order: PathwayEnzymeReaction/6850711
pathway order: PathwayEnzymeReaction/6850703
pathway order: PathwayEnzymeReaction/6850714
pathway order: PathwayEnzymeReaction/6850696
pathway order: PathwayEnzymeReaction/6850698
pathway order: PathwayEnzymeReaction/6850699
pathway component: ReactionCatalysis1240376
pathway component: ReactionCatalysis1240377
pathway component: 2.4.2.29
pathway component: 2.4.99.17
pathway component: 4.1.2.50
pathway component: Endocytosis
pathway component: Reaction5184
pathway component: 6.3.4.20
pathway component: 1.7.1.13
pathway component: Reaction1211158
pathway component: 3.5.4.16
pathway component: ReactionCatalysis1240380
pathway component: ReactionCatalysis1240382
pathway component: ReactionCatalysis1240383
pathway component: Reaction5179
pathway component: ReactionCatalysis1240374
pathway component: ReactionCatalysis1035171
xref: Reference/SMPDB SMP0645438
xref: Reference/PathWhiz PW685783
organism: Helicobacter canadensis MIT 98-5491

Reference/PubChem-compound 16741146
type: UnificationXref
id: 16741146
db: PubChem-compound

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Compound/PW C000986/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C007268
type: ChemicalStructure
structure format: SMILES
structure data: NCC1=CNC2=C1C(=O)NC(N)=N2

Reference/PubChem-compound 190
type: UnificationXref
id: 190
db: PubChem-compound

Compound/PW C042656/Stoichiometry/1.0
type: Stoichiometry
physical entity: epoxyqueuosine
stoichiometric coefficient: 1.0

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/KEGG Compound C16675
type: UnificationXref
id: C16675
db: KEGG Compound

Reference/HMDB HMDB0000990
type: UnificationXref
id: HMDB0000990
db: HMDB

Compound/PW C040034/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

ReactionCatalysis1240376
type: Catalysis
controller: 7-cyano-7-deazaguanine synthase
controlled: 6.3.4.20
control type: ACTIVATION

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

ReactionCatalysis1240377
type: Catalysis
controller: 7-cyano-7-deazaguanine reductase
controlled: 1.7.1.13
control type: ACTIVATION

ChemicalStructure/PW C042912
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)N1

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/HMDB HMDB0041827
type: UnificationXref
id: HMDB0041827
db: HMDB

SubPathwayInteraction512757
type: Interaction
name: SubPathway512757Reaction
name: SubPathwayReaction
participant: Guanosine triphosphate

Reference/PubChem-compound 171
type: UnificationXref
id: 171
db: PubChem-compound

Reference/PubChem-compound 177
type: UnificationXref
id: 177
db: PubChem-compound

Reference/ChemSpider 744
type: UnificationXref
id: 744
db: ChemSpider

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

ChemicalStructure/PW C000086
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC(=O)C2=C(N1)N=CN2

Compound/PW C001868/Stoichiometry/1.0
type: Stoichiometry
physical entity: Triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 185
type: UnificationXref
id: 185
db: ChemSpider

ReactionCatalysis1240380
type: Catalysis
controller: 7-cyano-7-deazaguanine reductase
controlled: Reaction1211158
control type: ACTIVATION

ReactionCatalysis1240382
type: Catalysis
controller: tRNA-guanine transglycosylase
controlled: 2.4.2.29
control type: ACTIVATION

ReactionCatalysis1240383
type: Catalysis
controller: S-adenosylmethionine:tRNA ribosyltransferase-isomerase
controlled: 2.4.99.17
control type: ACTIVATION

ReactionCatalysis1035171
type: Catalysis
controller: GTP cyclohydrolase I
controlled: 3.5.4.16
control type: ACTIVATION