PathWhiz

Pathway Description

Fructoselysine and Psicoselysine Degradation

Escherichia coli (strain K12 / MC4100 / BW2952)

Metabolic Pathway

Fructosamines are compounds that result from glycation reactions between a sugar and a primary amine, followed by isomerization via the Amadori rearrangement. In fructoselysine degradation, fructoselysine firstly converts to 1-[(5-Amino-5-carboxypentyl)amino]-1-deoxyfructose by protein frlC, and then 1-[(5-Amino-5-carboxypentyl)amino]-1-deoxyfructose is transformed to fructoselysine-6-phosphate by fructoselysine kinase which is powered by ATP. Fructoselysine-6-phosphate finally degrades to β-D-Glucose 6-phosphate and L-lysine by fructoselysine 6-phosphate deglycase.

References

Fructoselysine and Psicoselysine Degradation References

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from PW002049

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Visualize Compound Data

		1-[(5-Amino-5-carboxypentyl)amino]-1-deoxyfructose
		Adenosine diphosphate
		Adenosine triphosphate
		Fructose
		Fructoselysine
		Fructoselysine-6-phosphate
		Hydrogen Ion
		L-Lysine
		Water
		β-D-Glucose 6-phosphate