PathWhiz

PathWhiz ID	Pathway	Meta Data
PW126395 View Pathway	metabolic Aerobic Glycolysis (Warburg Effect) in T Lymphocytes Homo sapiens The "Warburg effect" is historically associated with tumour cell generation of energy through glycolysis. However, this process is a less efficient way to produce ATP. It has recently been proposed to function as a metabolism adaptation to increase the uptake and incorporation of nutrients (nucleotides, amino acids, lipids, etc.), which allows the production of a new cell. This concept extends past tumour cells and into any cell that proliferates, specifically T lymphocyte cells. T cells are one of the most important white blood cells, and they are essential for the adaptive/acquired immune system. Glucose is converted to pyruvic acid via glycolysis. Pyruvate Kinase M2 is downregulated by tyrosine kinases (PI3K/Akt pathway). This downregulation will allow more lactic acid production by Lactate dehydrogenase A (LDHA). LDHA sustains aerobic glycolysis by regenerating NAD+ used in the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) glycolysis step. In activated T cells, this increased activity of GAPDH will promote the expression of IFNg. The IFNg cytokine is essential for the T cell proliferation pathway. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ashley Zubkowski Created On: November 04, 2021 at 11:35 Last Updated: November 04, 2021 at 11:35
PW145615 View Pathway	drug action Afamelanotide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:13 Last Updated: October 07, 2023 at 16:13
PW128495 View Pathway	drug action Afatinib Action Pathway Homo sapiens Afatinib is a tyrosine kinase inhibitor used as an antineoplastic agent for the treatment of advanced or metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations or resistance to platinum-based chemotherapy. Afatinib binds the phosphorylation domain of the epidermal growth factor receptor. This inhibits the activation of this receptor, thus the cascading signaling pathways, through RAS, can't happen. As a result, this drug provokes the inhibition of cell (cancer) proliferation. Also, Afatinib inhibits the receptor tyrosine-protein kinase erbB-2 and erbB-4. Those receptors usually send a signal to the cell to survive (through the transcription of many proteins and with the help of P13K, AKT, and mTOR). The inhibition of those receptors results in the inhibition of the survival of the cell (death/apoptosis). This drug is administered as an oral tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: August 31, 2023 at 15:48 Last Updated: August 31, 2023 at 15:48
PW145889 View Pathway	drug action Afatinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:54 Last Updated: October 07, 2023 at 16:54
PW002692 View Pathway	signaling Agnieszka Bielska Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: June 16, 2016 at 06:19 Last Updated: June 16, 2016 at 06:19
PW012844 View Pathway	metabolic Agnieszka Bielska 1471277183 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: August 15, 2016 at 10:06 Last Updated: August 15, 2016 at 10:06
PW145720 View Pathway	drug action Agomelatine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:28 Last Updated: October 07, 2023 at 16:28
PW176372 View Pathway	metabolic Agomelatine Predicted Metabolism Pathway Homo sapiens Metabolites of Agomelatine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 16:25 Last Updated: December 07, 2023 at 16:25
PW128330 View Pathway	drug action Agomelatine Serotonin Antagonist Action Pathway Homo sapiens Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors and promotes dopamine and norepinephrine release. Agomelatine is indicated to treat major depressive episodes in adults. It is an atypical antidepressant. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 21, 2023 at 16:01 Last Updated: August 21, 2023 at 16:01
PW122139 View Pathway	signaling Agrin in Postsynaptic Differentiation Homo sapiens Agrin and acetylcholine act in parallel to shape the postsynaptic apparatus, and skeletal neuromuscular junction development depends critically on the interactions between these factors. In addition to its role in clustering acetylcholine, which has been demonstrated in vitro, agrin also acts to antagonize the effect of acetylcholine receptors. The antideclustering effects of agrin are physiologically crucial, agrin's antideclustering effects in vitro require its z-exon which has been shown to be required for postsynaptic differentiation in vivo. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Noah Created On: September 12, 2018 at 09:27 Last Updated: September 12, 2018 at 09:27