PathWhiz

PathWhiz ID	Pathway	Meta Data
PW127874 View Pathway	drug action Alternative Antithrombin Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: June 13, 2023 at 19:21 Last Updated: June 13, 2023 at 19:21
PW122167 View Pathway	protein Alternative Complement Pathway Mus musculus The alternative complement pathway is one of the three complement pathways, the other two being classical and lectin. These pathways work innately to opsonize pathogens and kill them. The alternative pathway is activated with the complement C3 protein is cleaved spontaneously in the blood. The C3b component is then free to covalently bond to the surface of pathogens or apoptotic cells, acting as a tag for other parts of the immune system. Complement factor B is cleaved into factors Ba and Bb, and factor Bb can then bind to complement factor C3b on the surface of the pathogen along with a water molecule. This complex is known as fluid-phase C3 convertase, and it cleaves many more C3 proteins into C3a and C3b. Properdin is another compound that is important for complement activation, and it binds to the C3bBb complex, stabilizing it and forming the C3bBbP complex. This complex then can bind another C3b protein, and it then functions as a C5 convertase, splitting C5 into C5a and C5b. At this point, the remainder of the pathway is the same between the alternative and classical pathways. The complement C5b protein binds to and forms a complex with component C6, followed by C7, C8 and C9. Multiple molecules of C9 end up binding to this complex, and this is what forms the membrane attack complex pore that allows for uncontrolled diffusion of the cell’s contents, and if enough pores are formed, the cell will be killed. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 14:47 Last Updated: September 20, 2018 at 14:47
PW122215 View Pathway	protein Alternative Complement Pathway Rattus norvegicus The alternative complement pathway is one of the three complement pathways, the other two being classical and lectin. These pathways work innately to opsonize pathogens and kill them. The alternative pathway is activated with the complement C3 protein is cleaved spontaneously in the blood. The C3b component is then free to covalently bond to the surface of pathogens or apoptotic cells, acting as a tag for other parts of the immune system. Complement factor B is cleaved into factors Ba and Bb, and factor Bb can then bind to complement factor C3b on the surface of the pathogen along with a water molecule. This complex is known as fluid-phase C3 convertase, and it cleaves many more C3 proteins into C3a and C3b. Properdin is another compound that is important for complement activation, and it binds to the C3bBb complex, stabilizing it and forming the C3bBbP complex. This complex then can bind another C3b protein, and it then functions as a C5 convertase, splitting C5 into C5a and C5b. At this point, the remainder of the pathway is the same between the alternative and classical pathways. The complement C5b protein binds to and forms a complex with component C6, followed by C7, C8 and C9. Multiple molecules of C9 end up binding to this complex, and this is what forms the membrane attack complex pore that allows for uncontrolled diffusion of the cell’s contents, and if enough pores are formed, the cell will be killed. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 15:03 Last Updated: September 20, 2018 at 15:03
PW064820 View Pathway	protein Alternative Complement Pathway Homo sapiens The alternative complement pathway is one of the three complement pathways, the other two being classical and lectin. These pathways work innately to opsonize pathogens and kill them. The alternative pathway is activated with the complement C3 protein is cleaved spontaneously in the blood. The C3b component is then free to covalently bond to the surface of pathogens or apoptotic cells, acting as a tag for other parts of the immune system. Complement factor B is cleaved into factors Ba and Bb, and factor Bb can then bind to complement factor C3b on the surface of the pathogen along with a water molecule. This complex is known as fluid-phase C3 convertase, and it cleaves many more C3 proteins into C3a and C3b. Properdin is another compound that is important for complement activation, and it binds to the C3bBb complex, stabilizing it and forming the C3bBbP complex. This complex then can bind another C3b protein, and it then functions as a C5 convertase, splitting C5 into C5a and C5b. At this point, the remainder of the pathway is the same between the alternative and classical pathways. The complement C5b protein binds to and forms a complex with component C6, followed by C7, C8 and C9. Multiple molecules of C9 end up binding to this complex, and this is what forms the membrane attack complex pore that allows for uncontrolled diffusion of the cell’s contents, and if enough pores are formed, the cell will be killed. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Jonas Patron Created On: July 25, 2018 at 11:18 Last Updated: July 25, 2018 at 11:18
PW122191 View Pathway	protein Alternative Complement Pathway Bos taurus The alternative complement pathway is one of the three complement pathways, the other two being classical and lectin. These pathways work innately to opsonize pathogens and kill them. The alternative pathway is activated with the complement C3 protein is cleaved spontaneously in the blood. The C3b component is then free to covalently bond to the surface of pathogens or apoptotic cells, acting as a tag for other parts of the immune system. Complement factor B is cleaved into factors Ba and Bb, and factor Bb can then bind to complement factor C3b on the surface of the pathogen along with a water molecule. This complex is known as fluid-phase C3 convertase, and it cleaves many more C3 proteins into C3a and C3b. Properdin is another compound that is important for complement activation, and it binds to the C3bBb complex, stabilizing it and forming the C3bBbP complex. This complex then can bind another C3b protein, and it then functions as a C5 convertase, splitting C5 into C5a and C5b. At this point, the remainder of the pathway is the same between the alternative and classical pathways. The complement C5b protein binds to and forms a complex with component C6, followed by C7, C8 and C9. Multiple molecules of C9 end up binding to this complex, and this is what forms the membrane attack complex pore that allows for uncontrolled diffusion of the cell’s contents, and if enough pores are formed, the cell will be killed. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 14:55 Last Updated: September 20, 2018 at 14:55
PW128241 View Pathway	drug action Altretamine Action Pathway Homo sapiens Altretamine, also known as Hexalen, is a novel alkylating agent from the antineoplastic drug class. This drug is used as a palliative treatment for patients with persistent or recurrent ovarian cancer. The precise mechanism of action of the drug is still not completely understood. It is known that following administration, the molecule goes through N-demethylation by the cytochrome P450 monooxygenases in the liver. This generates carbinalamine as an intermediate leading after to the formaldehyde and smaller inactive compounds. When the carbinalamine losses its hydroxy group, it gives the iminium species. This last molecule is the one that probably binds to DNA. This drug is administered as an oral capsule. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: August 08, 2023 at 15:15 Last Updated: August 08, 2023 at 15:15
PW144610 View Pathway	drug action Altretamine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:01 Last Updated: October 07, 2023 at 14:01
PW146833 View Pathway	drug action Aluminium phosphate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:09 Last Updated: October 07, 2023 at 19:09
PW132250 View Pathway	metabolic Aluminum acetate Drug Metabolism Homo sapiens Aluminum acetate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Aluminum acetate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:24 Last Updated: September 21, 2023 at 20:24
PW146834 View Pathway	drug action Aluminum acetate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:09 Last Updated: October 07, 2023 at 19:09