PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128198 View Pathway	drug action Chlorambucil Action Pathway Homo sapiens Chlorambucil is an antineoplastic agent from the nitrogen mustard alkylating class. It is indicated in the treatment of chronic lymphatic leukemia, lymphosarcoma, giant follicular lymphoma, Hodgkin's disease, non-Hodgkin's lymphoma, and Waldenström’s macroglobulinemia. This class of agents is named like that for their ability to add alkyl groups to many electronegative groups. They work by three different mechanisms all of which achieve the same result: death of the cancerous cell. The first mechanism of action is to attach alkyl groups to DNA bases. This causes the fragmentation of the DNA by repair enzymes. Secondly, the alkylating agents cause damage to DNA via the formation of cross-links. The cross-links prevent the DNA from being separated for synthesis or transcription. The third mechanism of action is the induction of mispairing of the bases, leading to many mutations. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: August 01, 2023 at 12:52 Last Updated: August 01, 2023 at 12:52
PW144419 View Pathway	drug action Chlorambucil Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:36 Last Updated: October 07, 2023 at 13:36
PW000706 View Pathway	drug action Chloramphenicol Action Pathway Homo sapiens Chloramphenicol, trade names Pentamycetin and Chloromycetin, is a broad spectrum antibiotic originally derived from Streptomyces venezuelae. It inhibits protein synthesis by binding the 50S ribosomal subunit to prevent bacterial growth. Bacterial resistance has occurred through decreased uptake or permeability, ribosomal mutation and inactivation by acetylation. Adverse side effects such as aplastic anemia, bone-marrow suppression or Gray syndrome in neonates and infants have resulted in limited use. However, due to ampicillin-resistance bacterial meningitis there has been a renewed interest in the drug. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: June 23, 2014 at 03:57 Last Updated: June 23, 2014 at 03:57
PW127416 View Pathway	drug action Chloramphenicol Action Pathway - New Homo sapiens Chloramphenicol, trade names Pentamycetin and Chloromycetin, is a broad spectrum antibiotic originally derived from Streptomyces venezuelae . It inhibits protein synthesis by binding the 50S ribosomal subunit to prevent bacterial growth. Bacterial resistance has occurred through decreased uptake or permeability, ribosomal mutation and inactivation by acetylation. Adverse side effects such as aplastic anemia, bone-marrow suppression or Gray syndrome in neonates and infants have resulted in limited use. However, due to ampicillin-resistant bacterial meningitis, there has been a renewed interest in the drug. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Nitya Khetarpal Created On: January 25, 2023 at 07:54 Last Updated: January 25, 2023 at 07:54
PW144571 View Pathway	drug action Chloramphenicol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:55 Last Updated: October 07, 2023 at 13:55
PW146874 View Pathway	drug action Chloramphenicol palmitate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:15 Last Updated: October 07, 2023 at 19:15
PW176000 View Pathway	metabolic Chloramphenicol Predicted Metabolism Pathway new Homo sapiens Metabolites of Chloramphenicol are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 13:08 Last Updated: November 29, 2023 at 13:08
PW127417 View Pathway	drug action Chloramphenicol succinate Action Pathway Homo sapiens CS is a prodrug of chloramphenicol BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Nitya Khetarpal Created On: January 25, 2023 at 08:06 Last Updated: January 25, 2023 at 08:06
PW145828 View Pathway	drug action Chloramphenicol succinate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:46 Last Updated: October 07, 2023 at 16:46
PW176001 View Pathway	metabolic Chloramphenicol succinate Predicted Metabolism Pathway new Homo sapiens Metabolites of Chloramphenicol succinate are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 13:08 Last Updated: November 29, 2023 at 13:08