PathWhiz

PathWhiz ID	Pathway	Meta Data
PW122599 View Pathway	metabolic Chorismate Biosynthesis Pseudomonas aeruginosa Chorismate is an intermediate in tyrosine, phenylalanine and tryptophan synthesis and a precursor for folic acid, ubiquinone, enterochelin and menaquinone. Three enzymes catalyze the first step in chorismate biosynthesis. Synthesis may be reduced by feedback inhibition of tyrosine, phenylalanine and tryptophan to the enzymes. The biosynthesis of chorismate starts with D-Erythrose-4-phosphate getting transformed into 3-deoxy-D-arabino-heptulosonate-7-phosphate through a phospho-2-dehydro-3-deoxyheptonate aldolase. This is followed by a 3-dehydroquinate synthase converting the 3-deoxy-D-arabino-heptulosonate-7-phosphate into a 3-dehydroquinate which in turn is conveted to 3-dehydroshikimate through a 3-dehydroquinate dehydratase. At this point 3-dehydroshikimate can be turned into Shikimic acid through 2 different reactions involving Quinate/shikimate dehydrogenase and shikimate dehydrogenase 2. Shikimic acid is phosphorylated by Shikimate kinase 2 into shikimate 3-phosphate. Shikimate 3- phophate and a phosphoenolpyruvic acid are then joined through a 3-phosphoshikimate 1-carboxyvinyltransferase to produce a 5-enoylpyruvyl-shikimate 3-phosphate while releasing a phosphate. This in turn produces our final product Chorismate through a chorismate synthase. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 18:20 Last Updated: August 12, 2019 at 18:20
PW145998 View Pathway	drug action Chromic chloride Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:09 Last Updated: October 07, 2023 at 17:09
PW146836 View Pathway	drug action Chromic nitrate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:09 Last Updated: October 07, 2023 at 19:09
PW146259 View Pathway	drug action Chromium Cr-51 Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:48 Last Updated: October 07, 2023 at 17:48
PW146257 View Pathway	drug action Chromium Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:48 Last Updated: October 07, 2023 at 17:48
PW132265 View Pathway	metabolic Chromium gluconate Drug Metabolism Homo sapiens Chromium gluconate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Chromium gluconate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:28 Last Updated: September 21, 2023 at 20:28
PW146837 View Pathway	drug action Chromium gluconate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:09 Last Updated: October 07, 2023 at 19:09
PW132192 View Pathway	metabolic Chromium nicotinate Drug Metabolism Homo sapiens Chromium nicotinate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Chromium nicotinate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:02 Last Updated: September 21, 2023 at 20:02
PW146838 View Pathway	drug action Chromium nicotinate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:09 Last Updated: October 07, 2023 at 19:09
PW132202 View Pathway	metabolic Chromium picolinate Drug Metabolism Homo sapiens Chromium picolinate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Chromium picolinate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:06 Last Updated: September 21, 2023 at 20:06