PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176376 View Pathway	metabolic Cilostazol Predicted Metabolism Pathway Homo sapiens Metabolites of Cilostazol are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 16:28 Last Updated: December 07, 2023 at 16:28
PW000322 View Pathway	drug action Cimetidine Action Pathway Homo sapiens Cimetidine, sold as Tagamet, is a compound related to histamine. It is a H2 antagonist drug, also called H2RAs or H2 blockers, and was the first of this class to be discovered. H2 antagonist drugs compete with histamine to bind to the histamine H2-receptors found on the basolateral membrane of gastric parietal cells. This blocks histamine effects, resulting in reduced gastric acid secretion and a reduction in gastric volume and acidity. Cimetidine also helps to block pepsin and gastrin output, and due to the inhibition of gastric acid secretion, it is typically used to treat heartburn and ulcers. Cimetidine also blocks the activity of cytochrome P-450 enzymes CYP1A2, 2C9, 2C19, 2D6, 2E1 and 3A4, which may affect the metabolism of other drugs. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45
PW144623 View Pathway	drug action Cimetidine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:03 Last Updated: October 07, 2023 at 14:03
PW124499 View Pathway	drug action Cimetidine H2 Anti-Histamine Action Pathway Homo sapiens Cimetidine is an H2 receptor antagonist drug that is mainly used to treat peptic ulcers and heartburns. It works by acting as a competitive inhibitor and blocks the action of histamine on Histamine H2 receptors. This ultimately reduces gastric acid secretion in the stomach lumen by parietal cells that is caused by histamines interaction with the H2 receptor. This receptors activation causes downstream cascading signals that target the transporters pumping out hydrogen ions which leads to the secretion of acid in the stomach lumen. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Rahil Doshi Created On: February 02, 2021 at 12:27 Last Updated: February 02, 2021 at 12:27
PW124719 View Pathway	metabolic Cimetidine metabolism Homo sapiens Cimetidine, an H2 receptor antagonist drug mainly used to treat peptic ulcers and heartburns, is absorbed through the cells that line the small intestine into portal circulation. After it enters the liver hepatocyte from portal circulation, Cimetidine is metabolized by flavin containing monooxygenases and other P450 enzymes into cimetidine sulfoxide and hydroxymethyl cimetidine. These metabolites then enter systemic circulation. Research is still being conducted to find the specific types of enzymes that are involved in the metabolism of the drug into these metabolites. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Rahil Doshi Created On: April 15, 2021 at 02:24 Last Updated: April 15, 2021 at 02:24
PW125940 View Pathway	metabolic Cimetidine metabolism 1619814130 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: April 30, 2021 at 14:22 Last Updated: April 30, 2021 at 14:22
PW000593 View Pathway	drug metabolism Cimetidine Metabolism Pathway Homo sapiens Cimetidine, sold as Tagamet, is a compound related to histamine. It is a H2 antagonist drug, also called H2RAs or H2 blockers, and was the first of this class to be discovered. H2 antagonist drugs compete with histamine to bind to the histamine H2-receptors found on the basolateral membrane of gastric parietal cells. This blocks histamine effects, resulting in reduced gastric acid secretion and a reduction in gastric volume and acidity. Cimetidine also helps to block pepsin and gastrin output, and due to the inhibition of gastric acid secretion, it is typically used to treat heartburn and ulcers. Cimetidine also blocks the activity of cytochrome P-450 enzymes CYP1A2, 2C9, 2C19, 2D6, 2E1 and 3A4, which may affect the metabolism of other drugs. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: September 11, 2013 at 22:33 Last Updated: September 11, 2013 at 22:33
PW145110 View Pathway	drug action Cinacalcet Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:06 Last Updated: October 07, 2023 at 15:06
PW146780 View Pathway	drug action Cinnamaldehyde Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:01 Last Updated: October 07, 2023 at 19:01
PW146782 View Pathway	drug action Cinnamyl alcohol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:01 Last Updated: October 07, 2023 at 19:01