PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176006 View Pathway	metabolic Clobazam Predicted Metabolism Pathway new Homo sapiens Metabolites of Clobazam are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 13:10 Last Updated: November 29, 2023 at 13:10
PW147056 View Pathway	metabolic Clobetasol Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:45 Last Updated: October 10, 2023 at 13:45
PW127776 View Pathway	drug action Clobetasol propionate Action Pathway Homo sapiens Clobetasol propionate is a corticosteroid derived from prednisolone but with a higher specificity for glucocorticoid receptors than mineralocorticoid receptors. It is used to treat corticosteroid-responsive dermatoses and moderate to severe plaque psoriasis. By binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. Clobetasol propionate also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. Clobetasol propionate is administered as a topical cream, foam, aerosol, shampoo, gel, or ointment. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: June 01, 2023 at 13:47 Last Updated: June 01, 2023 at 13:47
PW145111 View Pathway	drug action Clobetasol propionate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:06 Last Updated: October 07, 2023 at 15:06
PW176007 View Pathway	metabolic Clobetasol propionate Predicted Metabolism Pathway new Homo sapiens Metabolites of Clobetasol propionate are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 13:11 Last Updated: November 29, 2023 at 13:11
PW127778 View Pathway	drug action Clobetasone Action Pathway Homo sapiens Clobetasone is a corticosteroid synthetically derived from cortisone. In dermatology, topical clobestasone helps to reduce the itchiness and erythema associated with eczema and dermatitis. In ophthalmology, clobetasone butyrate eye drops have been shown to be safe and effective in the treatment of dry eyes in Sjögren's Syndrome. As this drug is a glucocorticoid, its mechanism of action is that of the glucocorticoid response element (GRE) influencing COX-2/prostaglandin G/H synthase 2 suppression and lipocortin/annexin induction. By binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. Clobetasone also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: June 01, 2023 at 14:46 Last Updated: June 01, 2023 at 14:46
PW146597 View Pathway	drug action Clobetasone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:36 Last Updated: October 07, 2023 at 18:36
PW063744 View Pathway	drug action Clocinizine H1-Antihistamine Action Homo sapiens Clocinizine is a first-generation diphenylmethylpiperazine H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. Reducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic factors. Furthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release. First-generation antihistamines readily cross the blood-brain barrier and cause sedation and other adverse central nervous system (CNS) effects (e.g. nervousness and insomnia). Second-generation antihistamines are more selective for H1-receptors of the peripheral nervous system (PNS) and do not cross the blood-brain barrier. Consequently, these newer drugs elicit fewer adverse drug reactions. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: September 24, 2017 at 17:40 Last Updated: September 24, 2017 at 17:40
PW127779 View Pathway	drug action Clocortolone Action Pathway Homo sapiens Clocortolone, brand name Cloderm, is a corticosteroid used as a topical cream to treat inflammatory and pruritic dermatoses of the scalp. Clocortolone is a moderate potency topical corticosteroid that should not be used with occlusive dressings. As this drug is a glucocorticoid, its mechanism of action is that of the glucocorticoid response element (GRE) influencing COX-2/prostaglandin G/H synthase 2 suppression and lipocortin/annexin induction. By binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. Clocortolone also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: June 01, 2023 at 15:46 Last Updated: June 01, 2023 at 15:46
PW144943 View Pathway	drug action Clocortolone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:45 Last Updated: October 07, 2023 at 14:45