PathWhiz

PathWhiz ID	Pathway	Meta Data
PW122049 View Pathway	disease Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Rattus norvegicus Guanidinoacetate methyltransferase deficiency, also called GAMT deficiency, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of creatine metabolism caused by a defective guanidinoacetate methyltransferase (GAMT). GAMT catalyzes the conversion of guanidinoacetate into creatine which is used by creatine kinase to resynthesize adenosine triphosphate (ATP) from adenosine diphosphate (ADP). This disease is characterized by a large accumulation of guanidinoacetate and a decrease in creatine in the blood and urine. Symptoms of the disease include developmental delay, hypotonia, and seizures. Treatment with creatine supplementation is very effective. It is estimated that GAMT deficiency affects 1 in 250 000 individuals. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:51 Last Updated: September 10, 2018 at 15:51
PW121825 View Pathway	disease Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Mus musculus Guanidinoacetate methyltransferase deficiency, also called GAMT deficiency, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of creatine metabolism caused by a defective guanidinoacetate methyltransferase (GAMT). GAMT catalyzes the conversion of guanidinoacetate into creatine which is used by creatine kinase to resynthesize adenosine triphosphate (ATP) from adenosine diphosphate (ADP). This disease is characterized by a large accumulation of guanidinoacetate and a decrease in creatine in the blood and urine. Symptoms of the disease include developmental delay, hypotonia, and seizures. Treatment with creatine supplementation is very effective. It is estimated that GAMT deficiency affects 1 in 250 000 individuals. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:50 Last Updated: September 10, 2018 at 15:50
PW132605 View Pathway	metabolic Creatine Drug Metabolism Homo sapiens Creatine is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Creatine passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:36 Last Updated: September 21, 2023 at 22:36
PW144288 View Pathway	drug action Creatine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:06 Last Updated: October 07, 2023 at 13:06
PW123939 View Pathway	protein creb Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: June 18, 2020 at 03:07 Last Updated: June 18, 2020 at 03:07
PW123938 View Pathway	physiological CREB PATHWAY Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: June 18, 2020 at 03:03 Last Updated: June 18, 2020 at 03:03
PW000998 View Pathway	signaling CREB signalling Mus musculus BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: August 06, 2015 at 10:40 Last Updated: August 06, 2015 at 10:40
PW146262 View Pathway	drug action Cresol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:48 Last Updated: October 07, 2023 at 17:48
PW132322 View Pathway	metabolic Crisaborole Drug Metabolism Homo sapiens Crisaborole is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Crisaborole passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:54 Last Updated: September 21, 2023 at 20:54
PW145631 View Pathway	drug action Crisaborole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:15 Last Updated: October 07, 2023 at 16:15