PathWhiz

PathWhiz ID	Pathway	Meta Data
PW126267 View Pathway	metabolic Curcumin Biosynthesis Escherichia coli Curcumin can be biologically synthesized as an alternative to harsh chemical synthesis. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 05, 2021 at 10:58 Last Updated: October 05, 2021 at 10:58
PW001896 View Pathway	metabolic Curcumin Degradation Escherichia coli Curcumin is metabolized by being reduced through a NADPH dependent curcumin reductase resulting in a dihydrocurcumin. This compound is then reduced again through a NADPH-dependent dihydrocurcumin reductase resulting in a tetrahydrocurcumin. It is not know yet how this compound enters E.coli BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: September 10, 2015 at 16:04 Last Updated: September 10, 2015 at 16:04
PW146423 View Pathway	drug action Curcumin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:09 Last Updated: October 07, 2023 at 18:09
PW131631 View Pathway	metabolic CVnCoV Drug Metabolism Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: September 15, 2023 at 01:41 Last Updated: September 15, 2023 at 01:41
PW122220 View Pathway	protein CXCR4 Signaling Pathway Rattus norvegicus CXCR4 is a chemokine G-protein-coupled receptor. Chemokine receptors couple to the pertussis toxin-sensitive Gi proteins. It is involved in organogenesis, hematopoiesis, and the immune response. Chemokine stromal cell-derived factor 1 (SDF-1) binds CXCR4. CXCR4 is also a co-receptor for HIV and is involved in the metastasis of some cancers. Pertussis toxin ADP-ribosylates guanine nucleotide binding protein alpha inhibiting (Gai) proteins inhibiting GPCR/Gi coupling. Activated Gai inhibits adenylyl cyclase and activates tyrosine kinases, while activated guanine nucleotide binding protein beta and gamma activate PI3K - regulating gene transcription, cell migration, and cell adhesion. PLC is activated to cause the cleavage of PIP2 to IP3 and DG. This leads to the increase of calcium from the endoplasmic reticulum and the activation of protein kinase C. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 15:05 Last Updated: September 20, 2018 at 15:05
PW065635 View Pathway	protein CXCR4 Signaling Pathway Homo sapiens CXCR4 is a chemokine G-protein-coupled receptor. Chemokine receptors couple to the pertussis toxin-sensitive Gi proteins. It is involved in organogenesis, hematopoiesis, and the immune response. Chemokine stromal cell-derived factor 1 (SDF-1) binds CXCR4. CXCR4 is also a co-receptor for HIV and is involved in the metastasis of some cancers. Pertussis toxin ADP-ribosylates guanine nucleotide binding protein alpha inhibiting (Gai) proteins inhibiting GPCR/Gi coupling. Activated Gai inhibits adenylyl cyclase and activates tyrosine kinases, while activated guanine nucleotide binding protein beta and gamma activate PI3K - regulating gene transcription, cell migration, and cell adhesion. PLC is activated to cause the cleavage of PIP2 to IP3 and DG. This leads to the increase of calcium from the endoplasmic reticulum and the activation of protein kinase C. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Debra Lipton Created On: July 30, 2018 at 14:46 Last Updated: July 30, 2018 at 14:46
PW122172 View Pathway	protein CXCR4 Signaling Pathway Mus musculus CXCR4 is a chemokine G-protein-coupled receptor. Chemokine receptors couple to the pertussis toxin-sensitive Gi proteins. It is involved in organogenesis, hematopoiesis, and the immune response. Chemokine stromal cell-derived factor 1 (SDF-1) binds CXCR4. CXCR4 is also a co-receptor for HIV and is involved in the metastasis of some cancers. Pertussis toxin ADP-ribosylates guanine nucleotide binding protein alpha inhibiting (Gai) proteins inhibiting GPCR/Gi coupling. Activated Gai inhibits adenylyl cyclase and activates tyrosine kinases, while activated guanine nucleotide binding protein beta and gamma activate PI3K - regulating gene transcription, cell migration, and cell adhesion. PLC is activated to cause the cleavage of PIP2 to IP3 and DG. This leads to the increase of calcium from the endoplasmic reticulum and the activation of protein kinase C. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 14:49 Last Updated: September 20, 2018 at 14:49
PW122196 View Pathway	protein CXCR4 Signaling Pathway Bos taurus CXCR4 is a chemokine G-protein-coupled receptor. Chemokine receptors couple to the pertussis toxin-sensitive Gi proteins. It is involved in organogenesis, hematopoiesis, and the immune response. Chemokine stromal cell-derived factor 1 (SDF-1) binds CXCR4. CXCR4 is also a co-receptor for HIV and is involved in the metastasis of some cancers. Pertussis toxin ADP-ribosylates guanine nucleotide binding protein alpha inhibiting (Gai) proteins inhibiting GPCR/Gi coupling. Activated Gai inhibits adenylyl cyclase and activates tyrosine kinases, while activated guanine nucleotide binding protein beta and gamma activate PI3K - regulating gene transcription, cell migration, and cell adhesion. PLC is activated to cause the cleavage of PIP2 to IP3 and DG. This leads to the increase of calcium from the endoplasmic reticulum and the activation of protein kinase C. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 14:57 Last Updated: September 20, 2018 at 14:57
PW351742 View Pathway	metabolic Cyanate Degradation Citrobacter amalonaticus Y19 The cyanate degradation pathway begins with the transportation of cyanate into the cytosol through a cynX transporter. Once inside the cytosol cyanate reacts with hydrogen carbonate and a hydrogen ion through a cyanase resulting in the release of carbon dioxide and carbamate. Carbamate reacts spontaneously with hydrogen resulting in the release of ammonium and carbon dioxide. Carbon dioxide reacts with water through carbonic anhydrase resulting in the release of hydrogen ion and hydrogen carbonate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: November 07, 2024 at 20:38 Last Updated: November 07, 2024 at 20:38
PW351711 View Pathway	metabolic Cyanate Degradation Helicobacter bilis ATCC 43879 The cyanate degradation pathway begins with the transportation of cyanate into the cytosol through a cynX transporter. Once inside the cytosol cyanate reacts with hydrogen carbonate and a hydrogen ion through a cyanase resulting in the release of carbon dioxide and carbamate. Carbamate reacts spontaneously with hydrogen resulting in the release of ammonium and carbon dioxide. Carbon dioxide reacts with water through carbonic anhydrase resulting in the release of hydrogen ion and hydrogen carbonate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: November 07, 2024 at 20:14 Last Updated: November 07, 2024 at 20:14