PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146222 View Pathway	drug action Coal tar Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:42 Last Updated: October 07, 2023 at 17:42
PW146800 View Pathway	drug action Cobalt chloride Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:04 Last Updated: October 07, 2023 at 19:04
PW146854 View Pathway	drug action Cobalt Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:12 Last Updated: October 07, 2023 at 19:12
PW145948 View Pathway	drug action Cobicistat Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:02 Last Updated: October 07, 2023 at 17:02
PW145632 View Pathway	drug action Cobimetinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:15 Last Updated: October 07, 2023 at 16:15
PW126649 View Pathway	drug action Cocaine (New) - final Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Nitya Khetarpal Created On: February 08, 2022 at 16:41 Last Updated: February 08, 2022 at 16:41
PW000401 View Pathway	drug action Cocaine Action Pathway Homo sapiens Cocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Cocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. For this to happen, the sodium channel must first become active so that so that gating mechanism is in the open state. Therefore cocaine preferentially inhibits neurons that are actively firing. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45
PW124084 View Pathway	drug action Cocaine Action Pathway New Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Nitya Khetarpal Created On: August 16, 2020 at 23:43 Last Updated: August 16, 2020 at 23:43
PW126801 View Pathway	drug action Cocaine Analgesic Action Pathway Homo sapiens Cocaine is a local anesthesia and vasoconstrictor that is clinically used during diagnostic proceedures or during surgery in or through the nasal cavity. It comes in drugs called Goprelto and Numbrino which comes as a nasal spray. In these clinical drugs it takes the form of cocaine hydrochloride. The illicit drug has the same effects. Primarily it acts on sensory neurons in the nasal cavity by inhibiting the sodium channels. Stimulation from touch, pressure, stretch, or pain causes sodium channels on sensory receptors to open. Cocaine inhibits those channels, preventing the sensory receptor from depolarizing and triggering an action potential. The different types of sensory neurons it inhibits are mechanoreceptors(pressure, vibrations, and texture), thermoreceptors (temperature), and nociceptors (pain). The prevention of depolarization and action potential in these neurons causes an anesthetic effect in the nasal cavity. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: March 30, 2022 at 13:45 Last Updated: March 30, 2022 at 13:45
PW128143 View Pathway	drug action Cocaine Dopamine-reuptake Inhibitor Action Pathway Homo sapiens Cocaine is a local anesthesia and vasoconstrictor that is clinically used during diagnostic proceedures or during surgery in or through the nasal cavity. It comes in drugs called Goprelto and Numbrino which comes as a nasal spray. In these clinical drugs it takes the form of cocaine hydrochloride. The illicit drug has the same effects. It primarily acts on sensory neurons in the nasal cavity, but also inhibits dopamine, serotonin, and norepinephrine re-uptake channels. This inibition leads to an accumulation in the synapse of these neurotransmitters. For dopamine this leads to activation of dopamine receptors, especially the D2 dopamine receptor which has been implicated in the cause of addiction through the reward pathway. D2 receptors inhibit adenylate cyclase which leads to a lower concentration of cAMP which lowers neuronal excitability. Other dopamine receptors also have an effect on addiction,, especially the D1 dopamine receptor. The exact mechanisms in which D2 receptors cause addiction is unknown. D1 dopamine receptors also have an effect on addiction. They are Gs coupled and activated adenylate cyclase rather than inhibit. D1-D2 dopamine receptor heteromers have also been found to effect addiction, although they have not been researched enough to understand how. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: July 24, 2023 at 15:47 Last Updated: July 24, 2023 at 15:47