PathWhiz

PathWhiz ID	Pathway	Meta Data
PW000096 View Pathway	disease CHILD Syndrome Homo sapiens CHILD Syndrome, (Congenital Hemidysplasia with Icthyosiform Erythroderma and Limb Defects; Ichthyosiform Eruthroderma, Unilateral, with Epsilateral Malformations, Especially Absence Deformity of Limbs) is caused by a mutation in the gene encoding NADH steroid dehydrogenase-like protein (NSDHL). A defect in sterol-4 alpha-carboxylate 3-dehydrogenase, which normally catalyzes the reaction 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + NAD+ = 4-alpha-methyl-5-alpha-cholest-7-en-3-one + CO2 + NADH, causes accumulation of 8(9)cholestenol and 8-dehydrocholesterol in plasma. Symptoms of CHILD syndrome include hearing defects, hemidysplasia, unilateral hypomelia, ichthyosiform nevi, limb abnormalities, lung hypoplasia, and punctate calcifications. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 01, 2013 at 15:52 Last Updated: August 01, 2013 at 15:52
PW095688 View Pathway	metabolic Chitin Biosynthesis Drosophila melanogaster Chitin is a linear homopolymer of N-acetyl-β-D-glucosamine residues linked by β-1,4 glycosidic bonds to form microfibrils. These become the structural component to cell walls and many extracellular matrices such as cuticles and exoskeleton of insects. This process is highly conserved and occurs in many different organisms including insects and fungi. Chitin exist in several crystaline forms termed α, β and γ chitin, the most abundant being α chitin (reviewed in [Merzendorfer11]). Chitin and lipids are secreted by epidermal cells and form the basis for the cuticle material and layered structure. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Chelsea Hong Created On: August 18, 2018 at 13:23 Last Updated: August 18, 2018 at 13:23
PW122516 View Pathway	metabolic Chitin Digestion Clostridium taeniosporum BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Sizhe Qiu Created On: May 26, 2019 at 16:49 Last Updated: May 26, 2019 at 16:49
PW002042 View Pathway	metabolic Chitobiose Degradation Escherichia coli Diacetylchitobiose (also known as N,N'-diacetylchitobiose and chitobiose) is a sole source of carbon for E.coli. PTS system mannitol-specific EIICBA component facilitates the imports of diacetylchitobiose as well as the phosphorylation to diacetylchitobiose 6'-phosphate. Later on, diacetylchitobiose 6'-phosphate is hydrolyzed to N-monoacetylchitobiose 6'-phosphate, which also produce acetic acid. N-monoacetylchitobiose 6'-phosphate undergoes further hydrolyzation to form N-Acetyl-D-Glucosamine 6-Phosphate and glucosamine by monoacetylchitobiose-6-phosphate hydrolase. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: October 07, 2015 at 15:17 Last Updated: October 07, 2015 at 15:17
PW147038 View Pathway	metabolic Chlophedianol Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:42 Last Updated: October 10, 2023 at 13:42
PW145445 View Pathway	drug action Chloral hydrate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:50 Last Updated: October 07, 2023 at 15:50
PW128198 View Pathway	drug action Chlorambucil Action Pathway Homo sapiens Chlorambucil is an antineoplastic agent from the nitrogen mustard alkylating class. It is indicated in the treatment of chronic lymphatic leukemia, lymphosarcoma, giant follicular lymphoma, Hodgkin's disease, non-Hodgkin's lymphoma, and Waldenström’s macroglobulinemia. This class of agents is named like that for their ability to add alkyl groups to many electronegative groups. They work by three different mechanisms all of which achieve the same result: death of the cancerous cell. The first mechanism of action is to attach alkyl groups to DNA bases. This causes the fragmentation of the DNA by repair enzymes. Secondly, the alkylating agents cause damage to DNA via the formation of cross-links. The cross-links prevent the DNA from being separated for synthesis or transcription. The third mechanism of action is the induction of mispairing of the bases, leading to many mutations. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: August 01, 2023 at 12:52 Last Updated: August 01, 2023 at 12:52
PW144419 View Pathway	drug action Chlorambucil Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:36 Last Updated: October 07, 2023 at 13:36
PW000706 View Pathway	drug action Chloramphenicol Action Pathway Homo sapiens Chloramphenicol, trade names Pentamycetin and Chloromycetin, is a broad spectrum antibiotic originally derived from Streptomyces venezuelae. It inhibits protein synthesis by binding the 50S ribosomal subunit to prevent bacterial growth. Bacterial resistance has occurred through decreased uptake or permeability, ribosomal mutation and inactivation by acetylation. Adverse side effects such as aplastic anemia, bone-marrow suppression or Gray syndrome in neonates and infants have resulted in limited use. However, due to ampicillin-resistance bacterial meningitis there has been a renewed interest in the drug. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: June 23, 2014 at 03:57 Last Updated: June 23, 2014 at 03:57
PW127416 View Pathway	drug action Chloramphenicol Action Pathway - New Homo sapiens Chloramphenicol, trade names Pentamycetin and Chloromycetin, is a broad spectrum antibiotic originally derived from Streptomyces venezuelae . It inhibits protein synthesis by binding the 50S ribosomal subunit to prevent bacterial growth. Bacterial resistance has occurred through decreased uptake or permeability, ribosomal mutation and inactivation by acetylation. Adverse side effects such as aplastic anemia, bone-marrow suppression or Gray syndrome in neonates and infants have resulted in limited use. However, due to ampicillin-resistant bacterial meningitis, there has been a renewed interest in the drug. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Nitya Khetarpal Created On: January 25, 2023 at 07:54 Last Updated: January 25, 2023 at 07:54