PathWhiz

PathWhiz ID	Pathway	Meta Data
PW132456 View Pathway	metabolic Artemotil Drug Metabolism Homo sapiens Artemotil is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Artemotil passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:53 Last Updated: September 21, 2023 at 21:53
PW146684 View Pathway	drug action Artemotil Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:47 Last Updated: October 07, 2023 at 18:47
PW127426 View Pathway	drug action Artenimol Action Pathway Homo sapiens Artenimol is an artemisinin derivative and antimalarial agent used in the treatment of uncomplicated Plasmodium falciparum infections. It is used in combination with Piperaquine. Artemisinins, including Artenimol which is a major active metabolite of many artemisinins, are believed to bind to haem within the P. falciparum parasite. The source of this haem varies with the life stage of the parasite. When the parasite is in the early ring stage artemisinins are believed to bind haem produced by the parasite's haem biosynthesis pathway. In later stages artemisinins likely bind to haem released by haemoglobin digestion. Once bound to haem, artemisinins are thought to undergo activation involving ferrous iron via reductive scission which splits the endoperoxide bridge to produce a reactive oxygen. This reactive oxygen is thought to undergo a subsequent intramolecular hydrogen abstraction to produce a reactive carbon radical. The carbon radical is believed to be the source of the drugs potent activity against P. falciparum by alkylating a wide array of protein targets. The nature and magnitude of the effect on specific protein function as a result of this alkylation is unknown. One target which has been the focus of research is the sarco/endoplasmic reticulum Ca2+ ATPase pump of P. falciparum. Artemisinins have been found to irreversably bind to and inhibit this protein at a binding site similar to that of Thapsigargin. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: January 29, 2023 at 15:09 Last Updated: January 29, 2023 at 15:09
PW146415 View Pathway	drug action Artenimol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:08 Last Updated: October 07, 2023 at 18:08
PW127429 View Pathway	drug action Artesunate Action Pathway Homo sapiens Artesunate is artesunate is an artemesinin derivative indicated for the initial treatment of severe malaria. Artesunate is an artemisinin derivative that is metabolized to DHA, which generates free radicals to inhibit normal function of Plasmodium parasites. Artesunate is metabolized in the liver to the active DHA. DHA enters the Plasmodium parasite. Once in the parasite iDHA reacts with heme, which generats free radicals which inhibit protein and nucleic acid synthesis of the Plasmodium parasites. Reactions with these free radicals can also lead to alkylation of parasitic proteins such as a calcium adenosine triphosphatase and EXP1, a glutathione S-transferase. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: January 31, 2023 at 09:12 Last Updated: January 31, 2023 at 09:12
PW146063 View Pathway	drug action Artesunate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:19 Last Updated: October 07, 2023 at 17:19
PW145920 View Pathway	drug action Articaine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:58 Last Updated: October 07, 2023 at 16:58
PW145693 View Pathway	drug action Arzoxifene Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:24 Last Updated: October 07, 2023 at 16:24
PW132547 View Pathway	metabolic Asciminib Drug Metabolism Homo sapiens Asciminib is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Asciminib passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:22 Last Updated: September 21, 2023 at 22:22
PW146544 View Pathway	drug action Asciminib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:28 Last Updated: October 07, 2023 at 18:28